ChemicalBook
Chinese English Japanese Germany Korea

L-글루타민

L-글루타민
L-글루타민 구조식 이미지
카스 번호:
56-85-9
한글명:
L-글루타민
동의어(한글):
2-아미노글루타라믹산;L-(+)-글루타민;L-글루타민;글루타민
상품명:
L-Glutamine
동의어(영문):
L-G;GLN;L-GLN;Glumin;Saforis;Miglu-P;Cebrogen;H-GLN-OH;L-Gln-OH;NSC 27421
CBNumber:
CB6280105
분자식:
C5H10N2O3
포뮬러 무게:
146.14
MOL 파일:
56-85-9.mol

L-글루타민 속성

녹는점
185 °C (dec.)(lit.)
알파
32.25 º (c=10, 2 N HCl)
끓는 점
265.74°C (rough estimate)
밀도
1.47 g/cm3 (20℃)
굴절률
6.8 ° (C=4, H2O)
FEMA
3684 | L-GLUTAMINE
인화점
185°C
저장 조건
−20°C
용해도
H2O: 25 mg/mL
물리적 상태
solution
산도 계수 (pKa)
2.17(at 25℃)
색상
White
수소이온지수(pH)
5.0-6.0 (25℃, 0.1M in H2O)
optical activity
[α]20/D +33.0±1°, c = 5% in 5 M HCl
수용성
Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform.
분해온도
185 ºC
최대 파장(λmax)
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck
14,4471
JECFA Number
1430
BRN
1723797
안정성
Stability Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents.
InChIKey
ZDXPYRJPNDTMRX-VKHMYHEASA-N
CAS 데이터베이스
56-85-9(CAS DataBase Reference)
NIST
L-Glutamine(56-85-9)
EPA
L-Glutamine(56-85-9)

안전

위험품 표기 Xi
위험 카페고리 넘버 36-36/37/38
안전지침서 26-24/25-36/37/39-27
WGK 독일 2
RTECS 번호 MA2275100
TSCA Yes
HS 번호 29241900
독성 LD50 orally in Rabbit: 7500 mg/kg

L-글루타민 MSDS


2-Aminoglutaramic acid

L-글루타민 C화학적 특성, 용도, 생산

개요

Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l .

화학적 성질

White crystalline powder

화학적 성질

White, odorless crystals or crystalline powder having a slightly sweet taste. It is soluble in water and practically insoluble in alcohol and in ether. Its solutions are acid to litmus. It melts with decomposition at about 185°C.

화학적 성질

L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis.

출처

Occurrences in nature
Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources
Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices.
Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease.

용도

L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

용도

L-Glutamine is one of the 20 amino acids encoded by the standard genetic code. Its codons are CAA and CAG. Glutamine is a substance naturally produced in the body to help regulate cell growth and function. There may also be man-made versions of these subs

용도

amine protecting agent

정의

ChEBI: An optically active form of glutamine having L-configuration.

제조 방법

By isolation from sugar beet juice.

상표명

Nutrestore (Nutritional Restart).

Biological Functions

Glutamine plays a role in a variety of biochemical functions, including :
Protein synthesis, as any other of the 20 proteinogenic amino acids
Regulation of acid-base balance in the kidney by producing ammonium
Cellular energy, as a source, next to glucose
Nitrogen donation for many anabolic processes, including the synthesis of purines
Carbon donation , as a source , refilling the citric acid cycle
Nontoxic transporter of ammonia in the blood circulation.

Safety Profile

Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.]

Producing and consuming organs

Producers
Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut.
Consumers
The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid - base balance, activated immune cells, and many cancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs.
Examples for the usage of glutamine
In catabolic states of injury and illness, glutamine becomes conditionally essential (requiring intake from food or supplements). Glutamine has been studied extensively over the past 10–15 years, and has been shown to be useful in treatment of injuries, trauma, burns, and treatment - related side effects of cancer, as well as in wound healing for postoperative patients. Glutamine is also marketed as a supplement used for muscle growth in weight lifting , body building, endurance, and other sports. Evidence indicates glutamine, when orally loaded, may increase plasma HGH levels by stimulating the anterior pituitary gland. In biological research, L-glutamine is commonly added to the media in cell culture. However, the high level of glutamine in the culture media may inhibit other amino acid transport activities.

L-글루타민 준비 용품 및 원자재

원자재

준비 용품


L-글루타민 공급 업체

글로벌( 519)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20653 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19919 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21909 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1771 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58

Copyright 2019 © ChemicalBook. All rights reserved