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Glutathion Produkt Beschreibung

Glutathione Struktur
70-18-8
CAS-Nr.
70-18-8
Bezeichnung:
Glutathion
Englisch Name:
Glutathione
Synonyma:
GSI;GSH;-GL;LGB-GT;copren;glutide;tathion;panaron;neuthion;isethion
CBNumber:
CB6320803
Summenformel:
C10H17N3O6S
Molgewicht:
307.32
MOL-Datei:
70-18-8.mol

Glutathion Eigenschaften

Schmelzpunkt:
192-195 °C (dec.) (lit.)
alpha 
-16.5 º (c=2, H2O)
Siedepunkt:
754.5±60.0 °C(Predicted)
Dichte
1.4482 (rough estimate)
Brechungsindex
-17 ° (C=2, H2O)
storage temp. 
2-8°C
Löslichkeit
H2O: 50 mg/mL
Aggregatzustand
powder
pka
pK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃)
Farbe
White
PH
3 (10g/l, H2O, 20°C)
Geruch (Odor)
Odorless
Wasserlöslichkeit
soluble
Merck 
14,4475
BRN 
1729812
Stabilität:
Stable. Incompatible with strong oxidizing agents.
InChIKey
RWSXRVCMGQZWBV-WDSKDSINSA-N
CAS Datenbank
70-18-8(CAS DataBase Reference)
EPA chemische Informationen
Glutathione (70-18-8)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 68-36/37/38
S-Sätze: 24/25-36/37/39-27-26
WGK Germany  2
RTECS-Nr. MC0556000
9-23
TSCA  Yes
HS Code  29309070

Glutathion Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R68:Irreversibler Schaden möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH is also involved in amino acid transport and maintenance of protein sulfhydryl reduction status. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.

Chemische Eigenschaften

White cryst. powder

Originator

L-Glutathione,Solgar,USA

Verwenden

Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons

Verwenden

glutathione is a peptide composed of cysteine, glycine, and glutamate. It is believed to enhance the skin’s cellular metabolism and oxygen utilization. It has been found to protect the fibroblast against free radical-induced oxidation and act as a powerful antioxidant. Studies indicate that it can inactivate the tyrosinase enzyme and quench free radicals that contribute to tyrosinase and melanin formation, thereby serving as a skin-lightening or de- pigmenting agent. glutathione is a component of plant and animal tissue, naturally occurring in the body and essential for the proper functioning of the immune system.

Verwenden

L-Glutathione is used in the treatment of lung diseases for patients who are HIV positive. It protects the cancerous cells by conferring resistance to chemotherapeutic drugs. It is involved in many aspects of metabolism including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds. As an antioxidant, it prevents damage to important cellular components that arise due to reactive oxygen species like free radicals and peroxide. It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca2+ ions. It is also used in white wine production.

Definition

ChEBI: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.

Manufacturing Process

The tripeptide thiol glutathione (L-γ-glutamyl-L-cysteinyl-glycine (GSH)) found in virtually all cells functions in metabolism, transport and cellular protection.
Glutathione may be obtained from an yeast or synthetically.
A yeast containing 600 parts of yeast solids is heated just to the boiling point of water. The yeast solids are removed by centrifuging or filtration. Sulphuric acid is added to the filtrate to give 0.5 N strength as sulphuric acid 6 parts of ascorbic acid are added. Then 2 parts of cuprous oxide are added with stirring. The reaction mixture is then centrifuged and washed until the precipitate is free from sulphates. The precipitate is suspended in 100 parts of water and hydrogen sulfide is bubbled through the water until all of the copper is precipitated as copper sulphide. The filtrate is evaporated and the glutathione is purified by recrystallization from 50% ethanol. All parts are by weight.
The preparation of glutathion by methods of peptide synthesis is expansive and gives 20-30% yield of GHS. For the first time synthetic glutathion was prepared by M. Bergmann et al.

Therapeutic Function

Anabolic, Antidote

Allgemeine Beschreibung

Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. GSH is also a key determinant of redox signaling and protection against oxidative stress.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Sicherheitsprofil

Moderately toxic by intravenous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

läuterung methode

Crystallise L-glutathione from 50% aqueous EtOH, dry it in a vacuum and

Glutathion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Glutathion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 764)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Sinoway Industrial co., ltd.
13806035118
0592-5854960 xie@china-sinoway.com CHINA 311 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
0531-88113608 info@pharmachemm.com CHINA 200 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5942 58
SINOPRO.CO.LTD
0082-42-721-7177
0082-42-3676760 michael@sinopro.co.kr South Korea 300 58
Hebei Yime New Material Technology Co., Ltd.
+8617703311139
admin@china-yime.com China 276 58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
+8617731987558
xingjiu@xingjiubiotech.com China 1000 58

70-18-8(Glutathion)Verwandte Suche:


  • glutatiol
  • glutatione
  • glutide
  • glutinal
  • isethion
  • l-glutatione
  • N(N-L-.gamma.-Glutamyl-L-cysteinyl)glycine
  • n-(n-l-gamma-glutamyl-l-cysteinyl)-glycin
  • neuthion
  • panaron
  • tathion
  • tathione
  • triptide
  • L-GLUTATHIONE REDUCED
  • L-Glutathione reduced Vetec(TM) reagent grade, >=98%
  • TWEEN 80 REAGENT GRADE
  • glutathiose
  • L-Glutathione Reduced(GSH)
  • Gamma Glu-L-Cys-Gly-OH
  • Glutathione(Reduced Form), free acid, Animal-Free
  • GLUTATHIONE FREE ACID REDUCED FORM*C
  • L-GLUTATHIONE REDUCED BIOXTRA
  • -1-((carboxymethyl)
  • -2-Amino-5-(((R)
  • -3-mercapto-1-oxopropan-2-yl)
  • Glutathione, For analysis, Reduced
  • L-GLUTATHIONE (REDUCED FORM)
  • Agifutol S
  • Glutathione (8CI)
  • Glycine, L-γ-glutamyl-L-cysteinyl-
  • Glycine, N-(N-L-γ-glutamyl-L-cysteinyl)-
  • N-(N-L-g-Glutamyl-L-cysteinyl)glycine
  • γ-Glutamylcysteinylglycine
  • GLYCINE,N-(N-GAMMA-GLUTAMYL-CYSTEINYL)-
  • REDUCEDGLUTHATIONE
  • GLUTATHIONE PHARMACEUTICAL GRADE
  • L-GLUTATHIONE REDUCED ( INJECTABLE GRADE )
  • L-GLUTATHIONE REDUCED ( ORAL GRADE )
  • G1UTATHION
  • L-.GLUTATHIONE (REDUCED) [N-(N-L-G-GLUTAMYL-L-CYSTEINYL)GLYCINE]
  • Bakezyme RX
  • GLUTAMYCYSTEINYLGLYCINE
  • GLUTATHIONE REDUCED extrapure for
  • 2-Amino-4-[[1-(carboxymethylcarbamoyl)-2-sulfanyl-ethyl]carbamoyl]butanoic acid
  • Glutathione, 98%, reduced, for analysis
  • Glutathione,98%,for analysis,reduced
  • Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-
  • Glutathion,oxidation
  • L-Glutathione ,99%
  • L-GLUTATHIONE (REDUCED FORM)CRYST. RESEARCH GRADE
  • L-Glutathione reduced,γ-L-Glutamyl-L-cysteinyl-glycine, GSH
  • L-Glutathione ,99% [for analysis,reduced]
  • Glutathione Readuced
  • Glutathione (300 mg)
  • REDUCED GLUTATHIONE
  • lutathione, reduced Glutathione
  • Glutathione EP
  • Glutathione USP
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