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Prednison Produkt Beschreibung

Prednisone Struktur
53-03-2
CAS-Nr.
53-03-2
Bezeichnung:
Prednison
Englisch Name:
Prednisone
Synonyma:
MOPP;u6020;Cortan;Deltra;Cotone;deltae;U 6020;Wojtab;delta-E;In-Sone
CBNumber:
CB6716222
Summenformel:
C21H26O5
Molgewicht:
358.43
MOL-Datei:
53-03-2.mol

Prednison Eigenschaften

Schmelzpunkt:
236-238 °C(lit.)
alpha 
169 º (c=0.5, dioxane)
Siedepunkt:
410.86°C (rough estimate)
Dichte
1.1121 (rough estimate)
Brechungsindex
170 ° (C=0.5, Dioxane)
Flammpunkt:
>200℃
storage temp. 
Refrigerator
Löslichkeit
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
Boiling Point
573.7±50.0 °C(Predicted)
Density
1.30±0.1 g/cm3(Predicted)
Melting Point
234 °C (decomp)
pka
12.36±0.60(Predicted)
Merck 
7722
BRN 
2065301
Stabilität:
Stable. Incompatible with strong oxidizing agents.
CAS Datenbank
53-03-2(CAS DataBase Reference)
NIST chemische Informationen
Prednisone(53-03-2)
EPA chemische Informationen
Prednisone (53-03-2)

Sicherheit

Kennzeichnung gefährlicher Xn,C,F
R-Sätze: 63-34-11
S-Sätze: 36/37/39-45-26-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS-Nr. TU4154100
HazardClass  IRRITANT
HS Code  29379000
Giftige Stoffe Daten 53-03-2(Hazardous Substances Data)

Prednison Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R34:Verursacht Verätzungen.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

White or almost white, crystalline powder.

Verwenden

Adrenocortical steroid. Glucocorticoid, antiinflammatory.

Verwenden

Downregulates TNF-α production and NF-κB expression

Definition

ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.

Trademarks

Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).

Allgemeine Beschreibung

Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.

Allgemeine Beschreibung

Odorless white crystalline powder.

Air & Water Reaktionen

Very slightly water soluble .

Hazard

Questionable carcinogen.

Sicherheitsprofil

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.

läuterung methode

Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]

Prednison Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prednison Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 268)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21686 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22633 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 570 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29996 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23981 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58

53-03-2(Prednison)Verwandte Suche:


  • Prednisolone EP Impurity B
  • 1,2-Dehydrocortisone
  • 1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione
  • 11,20-trione,17,21-dihydroxy-pregna-4-diene-3
  • 11,20-trione,17,21-hydroxy-pregna-4-diene-3
  • Ancortone
  • Bicortone
  • Colisone
  • Cortan
  • Cortancyl
  • Cortidelt
  • delta-E
  • Deltasone
  • delta-sone
  • Deltison
  • Deltisone
  • Deltra
  • Di-Adreson
  • Encorton
  • Encortone
  • Enkorton
  • Hostacortin
  • In-Sone
  • Juvason
  • Lisacort
  • meburamide
  • Metacortandracin
  • Meticorten
  • NCI-C04897
  • nci-co4897
  • NSC 10023
  • nsc10023
  • Orasone
  • Paracort
  • Precort
  • Prednicen-M
  • Prednilonga
  • Prednizon
  • 1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • (8S,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-7,8,9,10,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,11-DIONE
  • Prednisone,98%
  • PREDNISONE, PH EUR
  • 1,4-pregnadiene-17α,21-diol-3,11,20-trione
  • PREDNISONE,ANHYDROUS,MICRONIZED,USP
  • PREDNISONE,ANHYDROUS,POWDER,USP
  • MOPP
  • 1,4-Pregnadiene-17a,21-diol-3,11,20-trione
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone, Prednisonum
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
  • Apo-Prednisone
  • Ancotone
  • 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
  • 53-03-2
  • Prednisolone Impurity 2(Prednisolone EP Impurity B)
  • Cotone
  • Dacortin
  • Decortancyl
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