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Prednison Produkt Beschreibung

Prednisone Struktur
53-03-2
CAS-Nr.
53-03-2
Bezeichnung:
Prednison
Englisch Name:
Prednisone
Synonyma:
MOPP;u6020;Cortan;Deltra;Cotone;deltae;U 6020;Wojtab;delta-E;In-Sone
CBNumber:
CB6716222
Summenformel:
C21H26O5
Molgewicht:
358.43
MOL-Datei:
53-03-2.mol

Prednison Eigenschaften

Schmelzpunkt:
236-238 °C(lit.)
alpha 
169 º (c=0.5, dioxane)
Siedepunkt:
410.86°C (rough estimate)
Dichte
1.1121 (rough estimate)
Brechungsindex
170 ° (C=0.5, Dioxane)
Flammpunkt:
>200℃
storage temp. 
Refrigerator
Löslichkeit
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pka
12.36±0.60(Predicted)
Wasserlöslichkeit
115mg/L(25 ºC)
Merck 
7722
BRN 
2065301
Stabilität:
Stable. Incompatible with strong oxidizing agents.
CAS Datenbank
53-03-2(CAS DataBase Reference)
IARC
3 (Vol. 26, Sup 7) 1987
NIST chemische Informationen
Prednisone(53-03-2)
EPA chemische Informationen
Prednisone (53-03-2)

Sicherheit

Kennzeichnung gefährlicher Xn
S-Sätze: 36/37/39-45-26-16
Giftige Stoffe Daten 53-03-2(Hazardous Substances Data)

Prednison Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R34:Verursacht Verätzungen.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

White or almost white, crystalline powder.

Verwenden

Adrenocortical steroid. Glucocorticoid, antiinflammatory.

Verwenden

Downregulates TNF-α production and NF-κB expression

Definition

ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.

Indications

Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.

Trademarks

Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).

Allgemeine Beschreibung

Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.

Allgemeine Beschreibung

Odorless white crystalline powder.

Air & Water Reaktionen

Very slightly water soluble .

Hazard

Questionable carcinogen.

Sicherheitsprofil

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.

läuterung methode

Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]

Prednison Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prednison Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 295)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21807 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22623 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30032 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28230 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23040 58

53-03-2(Prednison)Verwandte Suche:


  • 1,2-Dehydrocortisone
  • 1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione
  • 11,20-trione,17,21-dihydroxy-pregna-4-diene-3
  • 11,20-trione,17,21-hydroxy-pregna-4-diene-3
  • Ancortone
  • Bicortone
  • Colisone
  • Cortan
  • Cortancyl
  • Cortidelt
  • delta-E
  • Deltasone
  • delta-sone
  • Deltison
  • Deltisone
  • Deltra
  • Di-Adreson
  • Encorton
  • Encortone
  • Enkorton
  • Hostacortin
  • In-Sone
  • Juvason
  • Lisacort
  • meburamide
  • Metacortandracin
  • Meticorten
  • NCI-C04897
  • nci-co4897
  • NSC 10023
  • nsc10023
  • Orasone
  • Paracort
  • Precort
  • Prednicen-M
  • Prednilonga
  • Prednizon
  • 1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • (8S,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-7,8,9,10,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,11-DIONE
  • PREDNISONE, PH EUR
  • Prednisone,98%
  • 1,4-Pregnadiene-17a,21-diol-3,11,20-trione
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
  • 1,4-pregnadiene-17α,21-diol-3,11,20-trione
  • PREDNISONE,ANHYDROUS,MICRONIZED,USP
  • PREDNISONE,ANHYDROUS,POWDER,USP
  • MOPP
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone, Prednisonum
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
  • Apo-Prednisone
  • Ancotone
  • 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
  • Prednisolone EP Impurity B
  • Prednisolone Impurity 2(Prednisolone EP Impurity B)
  • Cotone
  • Dacortin
  • Decortancyl
  • Decortin
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