9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Struktur

981-34-0

CAS-Nr.: 981-34-0

Bezeichnung:: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion

Englisch Name:: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Synonyma:: DB11;(9β,11β,16β)-;Einecs 213-563-4;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid;16-BETA METHYL EPOXIDE;DB11(16β-Methyl Epoide);DB11(16B-Methyl Epoide)

CBNumber:: CB72129663

Summenformel:: C22H28O5

Molgewicht:: 372.45

MOL-Datei:: 981-34-0.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 220

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Eigenschaften

Schmelzpunkt:: 210-220 ºC

Siedepunkt:: 564.9±50.0 °C(Predicted)

Dichte: 1.32±0.1 g/cm3(Predicted)

Dampfdruck: 0-357.304Pa at 25℃

storage temp.: Refrigerator

Löslichkeit: Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)

Aggregatzustand: Solid

pka: 12.56±0.70(Predicted)

Farbe: White to Light Beige

InChIKey: GBDXNHBVYAMODG-OBDZOPJXNA-N

SMILES: C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|

Sicherheit

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemische Eigenschaften

Off-White Solid

synthetische

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 220)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Nanjing Shizhou Biotechnology Co., Ltd	+86-15850508050 +86-15850508050	sean.lv@synzest.com	China	323	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

981-34-0(9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion)Verwandte Suche:

9β,11β-Epoxy-17,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion Ethylenoxid 9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat Propan-1,2-diol Estra-1,3,5(10)-trien-3,17α-diol Pregna-1,4-dien-3,20-dion, 9-Fluor-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Dinatriumsalz, (11β,16β)- Diphenylmethan-4,4'-diisocyanat Phenolic epoxy resin Basic Violet 1 Poly(ethylene glycol) 9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-21-acetat Methyl-4-hydroxybenzoat Methylenblau (C.I. 52015) Kresoxim-methyl Acetonitril BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Betamethason Methylacrylat

16-BETA METHYL EPOXIDE
9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
(9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Einecs 213-563-4
Betamethasone 9,11-Epoxide
(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione
(9β,11β,16β)-
9beta,11beta-Epoxy-1
DB11(16B-Methyl Epoide)
DB11(16β-Methyl Epoide)
(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
Betamethasone epoxide
(4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
Pregna-1,4-diene-3,20-dione,9
17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione
Beclomethasone EP Impurity R
Betamethasone Impurity 5（Betamethasone EP Impurity E）
Beclometasone Dipropionate?EP Impurity R
16-beta Methyl Epoxid
9,11beta-Epoxy-17,21-dihydroxy-16be
9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]
Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-
Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
Beclomethasone Impurity 6
Beclomethasone propionate EP impurity R
Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)
9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...
DB11(16β-Methyl Epoxide)
11beta-Epoxy-17alpha
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
DB11
Beclomethasone dipropionate EP Impurity R
9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione
Beclometasone Dipropionate Impurity R
Beclometasone Propionate EP Impurity R
Betamethasone Impurity E
Beclometasone Propionate EP Impurity R（Betamethasone EP Impurity E）
Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)
Betamethasone epoxy hydrolysate
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione
9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met
93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11)
Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
981-34-0
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals
Steroids
981-34-0