9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 속성
- 녹는점
- 210-220 ºC
- 끓는 점
- 564.9±50.0 °C(Predicted)
- 밀도
- 1.32±0.1 g/cm3(Predicted)
- 증기압
- 0-357.304Pa at 25℃
- 저장 조건
- Refrigerator
- 용해도
- Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 12.56±0.70(Predicted)
- 색상
- 흰색~밝은 베이지
- InChIKey
- GBDXNHBVYAMODG-OBDZOPJXNA-N
- SMILES
- C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|
안전
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione C화학적 특성, 용도, 생산
개요
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.화학적 성질
Off-White Solid제조 방법
Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 준비 용품 및 원자재
원자재
준비 용품
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 공급 업체
글로벌( 220)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 |
sean.lv@synzest.com | China | 323 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |