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Fludarabine phosphate Produkt Beschreibung

Fludarabine phosphate Struktur
75607-67-9
CAS-Nr.
75607-67-9
Englisch Name:
Fludarabine phosphate
Synonyma:
FAMP;Fludura;F-ara-AMP;75607-67-9;fludarabine hcl;2-fluoro-araamp;5-Monophosphate;Fludarbine Phopshate;ludarabine phosphate;Fludarabin Phosphate
CBNumber:
CB7347825
Summenformel:
C10H13FN5O7P
Molgewicht:
365.2116842
MOL-Datei:
75607-67-9.mol

Fludarabine phosphate Eigenschaften

Schmelzpunkt:
203°C(dec.)(lit.)
alpha 
[α]D20 +10~+14゜(c=0.5,H2O)
Siedepunkt:
864.2±75.0 °C(Predicted)
Dichte
2.39±0.1 g/cm3(Predicted)
RTECS-Nr.
UO7440900
storage temp. 
-20°C
Löslichkeit
DMSO: soluble1mg/mL
Aggregatzustand
Powder
pka
1.86±0.10(Predicted)
Farbe
white
Wasserlöslichkeit
Soluble in DMSO or water at 5mg/ml
Merck 
14,4126
InChIKey
GIUYCYHIANZCFB-GFRUICAKSA-N
CAS Datenbank
75607-67-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  2934990002
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H362 Kann Säuglinge über die Muttermilch schädigen. Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P261 Einatmen von Staub vermeiden.
P263 Kontakt während der Schwangerschaft /und der Stillzeit vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Fludarabine phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fludarabine phosphate is an antimetabolite indicated for the treatment of B cell lymphocytic leukemia. It is reportedly effective in patients refractory to other therapies. Fludarabine phosphate acts by inhibiting primer RNA synthesis. Its side effects include bone marrow suppression, anemia, thrombocytopenia and neutropenia.

Chemische Eigenschaften

White or almost white, crystalline powder, hygroscopic.

Originator

Southern Research Institute (U.S.A.)

Verwenden

anticonvulsant

Definition

ChEBI: A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Onc incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.

Trademarks

Fludara (Berlex).

Pharmakologie

Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Phase I studies in humans have demonstrated that fludarabine phosphate is rapidly converted to the active metabolite, 2-fluoro-ara-A, within minutes after intravenous infusion.
Consequently, clinical pharmacology studies have focused on 2-fluoro-ara-A pharmacokinetics. After the five daily doses of 25 mg 2-fluoro-ara-AMP/m2 to cancer patients infused over 30 minutes, 2-fluoro-ara-A concentrations show a moderate accumulation. During a 5-day treatment schedule, 2-fluoro-ara-A plasma trough levels increased by a factor of about 2. The terminal half-life of 2-fluoro-ara-A was estimated as approximately 20 hours. In vitro, plasma protein binding of fludarabine ranged between 19% and 29%.

Clinical Use

Fludarabine phosphate (Fludara ® ), is a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-β-D-arabinofuranosyladenine(ara-A), which differs only by the presence of a fluorine atom at position 2 of the purine moiety and a phosphate group at position 5 of the arabinose moiety (Plunkett et al., 1993). These structural modifications result in increased aqueous solubility and resistance to enzymatic degradation by adenosine deaminases compared to vidarabine (Brockman et al., 1977; Plunkett et al., 1990). Fludarabine phosphate is indicated for the treatment of patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating agent containing regimen (Boogaerts et al., 2001; Rossi et al., 2004).

Fludarabine phosphate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fludarabine phosphate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 350)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales03@yibaibiotech.com CHINA 420 58
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
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+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24723 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3035 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 309 58

75607-67-9()Verwandte Suche:


  • ((2R,3S,4S,5R)-5-(6-AMINO-2-FLUORO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE
  • FLUDARABINE PHOSPHATE (FLUDARABINE 5''-MONOPHOSPHATE)
  • 2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
  • 9-(5-O-Phosphono-β-D-arabinofuranosyl)-2-fluoro-9H-purine-6-amine
  • F-ara-AMP
  • 9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate
  • Fludarabine Phosphate (300 mg)
  • Fludarabine Phosphate(Fludara)
  • Fludarabine 5'-Phosphate
  • Fludarabine Phosphate API
  • FAMP
  • Fludarabine 5'-Monophosphate
  • Fludura
  • Fludrarbine Phosphate
  • Fludarabine Phosphate (Suitable to use for Tablet)
  • Fludarbine Phopshate
  • Fludarabine Phosphate USP
  • F-ara-A (NSC 312887) Phosphate
  • Fludarabine phosphate 9-bata-D-Arabinofuranosyl-2-fluoroadenine phosphate
  • Fludarabine for system suitability
  • 75607-67-9
  • Fluclarabine phosphate
  • ludarabine phosphate
  • 2-fluoro-9-(5-o-phosphono-beta-d-arabinofuranosyl)-9h-purin-6-amin
  • 2-Fluoro-9-β-D-arabinofuranosyladenine5'-monophosphate
  • 9-beta-d-arabinofuranosyl-2-fluoroadenine5’-monophosphate
  • fludarabinemonophosphate
  • 9-bata-d-arabinofuranosyl-2-fluoroadenine phosphate
  • 9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE-5'-DIHYDROGEN PHOSPHATE
  • FLUDARUBINE PHOSPHATE
  • FLUDARABINE PHOSPHATE
  • FludarabinePhosphateFdaInspected
  • FludarabinePhosphateUsp28
  • fludarabine hcl
  • 9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE PHOSPHATE
  • Fludarabin Phosphate
  • 2-fluoro-9-(5-o-phosphono-beta-d-arabinofuranosyl)-9h-purin-6-amine
  • 2-fluoro-araamp
  • 9-beta-arabinofuranosyl-2-fluoroadenine-5’-phosphate
  • 5-Monophosphate
  • Fludarabine phosphate 75607-67-9
  • Fludarabine (NSC-118218) phosphate
  • 75607-67-9
  • 21678-14-1
  • C10H13FN5O7P
  • Anti-cancer&immunity
  • Inhibitors
  • Active Pharmaceutical Ingredients
  • Antineoplastics
  • Antineoplastic
  • API
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