DMOG

DMOG Struktur
89464-63-1
CAS-Nr.
89464-63-1
Englisch Name:
DMOG
Synonyma:
DIMETHYLOXALYLGLYCINE;OMOG;Dimethyloxaloylglycine;DMOG;DMOG, >=98%;DMOG USP/EP/BP;DIMETHYLOXALLYL GLYCINE;Dimethyloxalylglycine (Dmog);DiMethyloxaloylglycine (DMOG);DMOG (dimethyloxaloylglycine)
CBNumber:
CB8223849
Summenformel:
C6H9NO5
Molgewicht:
175.14
MOL-Datei:
89464-63-1.mol

DMOG Eigenschaften

Schmelzpunkt:
46-48°C
Siedepunkt:
179-182 °C(Press: 12 Torr)
Dichte
1.246±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
H2O: >30mg/mL
pka
10.55±0.46(Predicted)
Aggregatzustand
Solid
Farbe
white to off-white
Wasserlöslichkeit
Soluble in water at 30mg/ml.
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions are not stable. Solutions must be made fresh and used within 1 working day.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi,Xn
R-Sätze: 22
WGK Germany  3
HS Code  2924.19.8000
HazardClass  IRRITANT
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

DMOG Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.

Chemische Eigenschaften

Off-White to Pale Pink Solid

Verwenden

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/Kg).

Enzyminhibitor

This iron-binding a-ketoglutarate (2-oxoglutarate) analogue (FW = 147.09 g/mol; also named N-oxaloglycine) competitively inhibits prolyl-4- hydroxylase (Reaction: Procollagen (L-proline) + a-ketoglutarate + O2 → Procollagen ( (2S,4R) -4-hydroxyproline) + succinate + CO2). During catalysis, prolyl-4-hydroxylase forms Fe (III), and the latter most likely makes an extremely stable metal ion complex with N-oxaloglycine. Substitution on the glycine moiety alters inhibitor activity stereoselectively and that, if the w-carboxylate is homologated or replaced, either by acylsulfonamides or anilide, activity is likewise sharply reduced. Prolyl- 4-Hydroxylase Catalysis: Each catalytic round of this posttranslational modifying enzyme reaction occurs in two stages. O2 is bound end-on in an axial position, producing a dioxygen unit. Nucleophilic attack at C-2 generates a tetrahedral intermediate, with loss of the double bond in dioxygen and bonds to iron and the a-carbon of a-ketoglutarate. Elimination of CO2 coincides with formation of the Fe (IV) =O species. The second stage involves the abstraction of the pro-R hydrogen atom from C-4 of proline, followed by radical combination, yielding hydroxyproline. In the presence of a-ketoglutarate, enzyme-bound Fe2+ is rapidly converted to Fe3+, resulting in inactivation of the enzyme Ascorbate is utilized as a cofactor to reduce Fe (III) back to Fe (II). Cell-Permeable Analogue: Dimethyloxalylglycine (FW = 175.14 g/mol; CAS 89464-63-1; Symbol: DMOG, also named N- (methoxyoxoacetyl) -glycine methyl ester) is metabolicaly demethylated to form N-oxaloglycine upon entry to many cells.

DMOG Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DMOG Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 142)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29220 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19915 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896
cbc@coresyn.com China 9991 58
ZHEJIANG JIUZHOU CHEM CO., LTD
+86-0576225566889 +86-13454675544
admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com China 20000 58

89464-63-1()Verwandte Suche:


  • N-(METHOXYOXOACETYL)-GLYCINE METHYL ESTER
  • DIMETHYLOXALLYL GLYCINE
  • N-[(Methoxycarbonyl)Methyl]oxaMic Acid Methyl Ester
  • DiMethyloxaloylglycine (DMOG)
  • METHYL 2-(2-METHOXY-2-OXOETHYLAMINO)-2-OXOACETATE
  • N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
  • DMOG Dimethyloxalylglycine N-[(Methoxycarbonyl)methyl]oxamic acid methyl ester
  • DMOG, >=98%
  • HIF-Hydroxylase Inhibitor, DMOG
  • Glycine,N-(2-methoxy-2-oxoacetyl)-, methyl ester
  • DMOG
  • DMOG (dimethyloxaloylglycine)
  • DMOG USP/EP/BP
  • methyl 2-(2-methoxy-2-oxoacetamido)acetate
  • Dimethyloxalylglycine (Dmog)
  • methyl n-[methoxy(oxo)acetyl]glycinate
  • DMOG; DIMETHYLOXALLYL GLYCINE; DIMETHYLOXALYLGLYCINE; 89464-63-1; METHYL N-[METHOXY(OXO)ACETYL]GLYCINATE
  • HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem
  • Dimethyloxaloylglycine
  • DIMETHYLOXALYLGLYCINE
  • OMOG
  • 89464-63-1
  • Other
  • Bio-material
  • NONE
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Inhibitors
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