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Carvedilol Produkt Beschreibung

Carvedilol Struktur
72956-09-3
CAS-Nr.
72956-09-3
Englisch Name:
Carvedilol
Synonyma:
Carca;COREG;Carvas;Carloc;Kredex;Querto;Artist;Cadilan;DQ-2466;Artione
CBNumber:
CB8351959
Summenformel:
C24H26N2O4
Molgewicht:
406.47
MOL-Datei:
72956-09-3.mol

Carvedilol Eigenschaften

Schmelzpunkt:
113-117°C
storage temp. 
Store at +4°C
Löslichkeit
DMSO: >20mg/mL
Aggregatzustand
solid
Farbe
white to off-white
Merck 
14,1873
CAS Datenbank
72956-09-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher N,Xn
R-Sätze: 51/53-36/37/38-20/21/22
S-Sätze: 61-36-26
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS-Nr. UA8670000
HazardClass  IRRITANT
PackingGroup  III
HS Code  2933995300
Giftige Stoffe Daten 72956-09-3(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

Carvedilol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Carvedilol is a vasodilating beta-blocker useful in the treatment of hypertension and angina pectoris. In addition to lowering blood pressure, carvedilol decreases total vascular resistance without the reflex tachycardia usually occurring with vasodilators. It is reported to be well tolerated with renal sparing effects.

Chemische Eigenschaften

Colourless Crystalline Solid

Originator

Boehringer Mannheim (Germany)

Verwenden

An α1- and β-adrenergic receptor antagonist.

Verwenden

A nonselective -adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.

Verwenden

antibacterial

Verwenden

Carvedilol is a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.

Verwenden

veterinary use

Verwenden

For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

Definition

ChEBI: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.

Trademarks

Coreg (GlaxoSmithKline);Dilatrend.

Allgemeine Beschreibung

Carvedilol (Coreg) is a β-blocker that hasa unique pharmacological profile. Like labetalol, it is aβ-blocker that possesses α1-blocking activity. Only the(S) enantiomer possesses the β-blocking activity, althoughboth enantiomers are blockers of the α1-receptor. Overall,its β-blocking activity is 10- to 100-fold of its α-blocking activity.

Biologische Aktivität

Potent β -adrenoceptor and α 1 -adrenoceptor antagonist (K i values are 0.81, 0.96 and 2.2 nM for β 1 -, β 2 - and α 1 -adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K + (K IR ) channels, voltage-dependent Ca 2+ channels and exhibits antioxidant properties at higher concentrations.

Clinical Use

Carvedilol is also unique in that it possesses antioxidantactivity and an antiproliferative effect on vascular smoothmuscle cells. It thus has a neuroprotective effect and the abilityto provide major cardiovascular organ protection. It isused in treating hypertension and congestive heart failure.

Veterinary Drugs and Treatments

Carvedilol may be useful as adjunctive therapy in the treatment of heart failure (dilated cardiomyopathy) in dogs. There is a fair amount of controversy at present among veterinary cardiologists as to whether this drug will find a therapeutic niche.

Carvedilol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Carvedilol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 253)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Chembon Pharmaceutical Co., Ltd.
+86-28-8425-2981
+86-28-8425-2965 info@chembon.com CHINA 724 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30003 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 176 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58

72956-09-3()Verwandte Suche:


  • Carvedilol (200 mg)
  • Cadilan
  • Carca
  • Cardivas
  • Carloc
  • Carvas
  • Korvasan
  • Talliton
  • Carvedilol API
  • 1-((9H-carbazol-4-yl)oxy)-3-((2-(2-Methoxyphenoxy)ethyl)aMino)propan-2-ol oxalate
  • Carvedilol EP
  • arvedilol
  • 1-((9H-Carbazol-4-yl)oxy)-3-((2-(2-Methoxyphenoxy)ethyl)aMino)propan-2-ol
  • Carvedilol 1-(9H-Carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol
  • Carvedilol for system suitability
  • Carvedilol Solution, 1000ppm
  • Carvedilol Solution, 100ppm
  • 1-(9h-carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol
  • Carvedilo
  • CarvedilolC24H26N204
  • Carvediloledmf/Gmpep5
  • CarvedilolEdmf/Gmp
  • CarvedilolEp5
  • 1(9H-CARBAZOL-4-YLOXY)-3-[[(2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL (CARVEDILOL)
  • 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-2-(2-methoxyphenoxy)ethylamino-
  • (±)-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl] [2-(2-methoxyphenoxy) ethyl]amine
  • RE-EXPORT: CARVEDILOL
  • Eucardic
  • Kredex
  • Querto
  • SKF 105517
  • BM-14190, 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
  • CarvedilolBp2003
  • (±)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol
  • (±)-1-(Carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
  • rac-(2R*)-1-(9H-Carbazole-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propane-2-ol
  • Artione
  • Artist
  • 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano
  • CARVEDILOL
  • COREG
  • DIMITONE
  • DQ-2466
  • DILATREND
  • BM-14190
  • 1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL
  • 72956-09-3
  • 72956-63-4
  • 72956-09-03
  • C24H26N2O4
  • Heterocycles
  • API
  • LEVAQUIN
  • Cardiovascular Drugs
  • -
  • Active Pharmaceutical Ingredients
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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