(-)-Gossypol
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- CAS-Nr.
- 90141-22-3
- Englisch Name:
- (-)-Gossypol
- Synonyma:
- CS-619;C:C&B61;(R)-Gossypol;(-)-Gossypol;AT 101, >=98%;GOSSYPOL，AT101;(R)-(-)-Gossypol;GOSSYPOL 90141-22-3;(-)-Gossypol USP/EP/BP;DL-gossypol acetic acid
- CBNumber:
- CB91437592
- Summenformel:
- C30H30O8
- Molgewicht:
- 518.55
- MOL-Datei:
- 90141-22-3.mol
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(-)-Gossypol Eigenschaften
- Schmelzpunkt:
- 166-167℃
- alpha
- D28 -386 to -390° (c = 0.5 g/100 g soln in CHCl3)
- Siedepunkt:
- 707.9±55.0 °C(Predicted)
- Dichte
- 1.403
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble15mg/mL, clear
- Aggregatzustand
- powder
- pka
- 7.15±0.50(Predicted)
- Farbe
- white to light brown
- Optische Aktivität
- [α]/D -350 to -365°, c = 0.3 (CDCl3)
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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(-)-Gossypol Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.
Biologische Aktivität
R-(-)-enantiomer of gossypol (Gossypol). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo .
Biochem/physiol Actions
AT101 [R-(-)-enantiomer of gossypol] is an orally available and well-tolerated natural BH3-mimetic that activates Bax and also induces mitochondrial Smac release. AT101 has shown anti-tumor activity as a single agent and in combination with standard anticancer drugs in a variety of tumor models. AT101 induced apoptosis in chemoresistant ovarian cancer cells.
(-)-Gossypol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(-)-Gossypol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 56)Lieferanten
90141-22-3()Verwandte Suche:
2-Methylpropylisocyanid
Methylisocyanacetat
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
(Pentan-2,4-dionato-O,O')silber
1,1,3,3-Tetramethylbutylisocyanat
(p-Toluolsulfonyl)methylisocyanid
Aluminiumtris(2,4-pentandionato-O,O')
Ethylisocyanacetat
Kupfer(II)-4-oxopent-2-en-2-olat
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
Dichloro(ethylendiamin)platin
Phenylselenol
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
N-Butylisocyanid
Tris(pentan-2,4-dionato)eisen(II)
Benzylisocyanid
- AT 101, >=98%
- DL-gossypol acetic acid
- (R)-(-)-Gossypol
- (R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
- (R)-Gossypol
- R-(-)-gossypol acetic acid
- GOSSYPOL 90141-22-3
- CS-619
- (R)-(-)-GOSSYPOL;R-(-)-GOSSYPOL ACETIC ACID
- C:C&B61
- [2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-
- (-)-Gossypol
- (-)-Gossypol USP/EP/BP
- GOSSYPOL，AT101
- 90141-22-3
- Inhibitors
