Vanoxerine dihydrochloride

Vanoxerine dihydrochloride Struktur
67469-78-7
CAS-Nr.
67469-78-7
Englisch Name:
Vanoxerine dihydrochloride
Synonyma:
I-893;GBR 12909;Vanoxerine;Boxeprazine;GBR129092HCl;Vanoxerine 2HCl;vanoxerine-GBR-12909;I893 dihydrochloride;GBR 12909 DIHYDROCHLORIDE;GBR 12909 (hydrochloride)
CBNumber:
CB9398144
Summenformel:
C28H33ClF2N2O
Molgewicht:
487.03
MOL-Datei:
67469-78-7.mol

Vanoxerine dihydrochloride Eigenschaften

Schmelzpunkt:
221 °C
storage temp. 
Sealed in dry,Room Temperature
Löslichkeit
DMSO: >5 mg/mL Solutions freshly prepared daily
Aggregatzustand
solid
Farbe
white
Wasserlöslichkeit
Soluble in DMSO to 50mM. Soluble to 5mM in water with warming.
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Sicherheit

WGK Germany  3
HS Code  2933.59.5300

Vanoxerine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM). It is more than 100-fold less effective at blocking serotonin or noradrenaline uptake. GBR 12909 effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors. GBR 12909 also inhibits pyrilamine binding to the histamine H1 receptor (IC50 = 18 nM) but poorly inhibits ligand binding to dopamine, adrenergic, acetylcholine, serotonin, and γ-aminobutyric acid receptors. It also blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM).

Verwenden

Vanoxerine dihydrochloride is a Dopamine reuptake inhibitor that is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.

Definition

ChEBI: Vanoxerine dihydrochloride is a hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. It has a role as a dopamine uptake inhibitor. It contains a vanoxerine(2+).

Allgemeine Beschreibung

Vanoxerine dihydrochloride is a potent inhibitor of dopamine active transporter (DAT, Ki = 1 nM, IC50 = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.

Hazard

A poison.

Biologische Aktivität

Potent, competitive inhibitor of dopamine uptake (K i = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC 50 = 48 nM). Centrally active following systemic administration.

Vanoxerine dihydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Vanoxerine dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 124)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ShenZhen Trendseen Biological Technology Co.,Ltd.
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1056@dideu.com China 3959 58
Dayang Chem (Hangzhou) Co.,Ltd.
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Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
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67469-78-7()Verwandte Suche:


  • 1-(2-[BIS(4-FLUOROPHENYL) METHOXY]ETHYL)-4-(3-PHENYLPROPYL) PIPERAZINE DIHYDROC
  • GBR-12909 DIHYDROCHLORIDE SELECTIVE DOPA MINE UP
  • GBR 12909
  • GBR 12909 DIHYDROCHLORIDE
  • 1-(2-BIS-((4-FLUOROPHENYL)METHOXY)ETHYL)-4-(3-PHENYL-2-PROPYL)PIPERAZINE HCL
  • 1-(2-BIS-[4-FLUOROPHENYL]-METHOXYETHYL)-4-(3-PHENYL-2-PROPYL)PIPERAZINE HYDROCHLORIDE
  • 1-[2-[BIS(4-FLUOROPHENYL)METHOXY]ETHYL]-4-[3-PHENYLPROPYL]PIPERAZINE DIHYDROCHLORIDE
  • Vanoxerine
  • GBR129092HCl
  • vanoxerine-GBR-12909
  • VANOXERINE DIHYDROCHLORIDE
  • 1-(3-Phenylpropyl)-4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazine
  • 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
  • I-893
  • Vanoxerine 2HCl
  • Vanoxerine 2HCl (GBR-12909)
  • GBR 12909 (hydrochloride)
  • Vanoxerine Dihydrochloride (GBR-12909)
  • I893 dihydrochloride
  • Piperazine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride(1:2)
  • Boxeprazine
  • Vanoxenine dihydrochloride
  • Vanoxerine dihydrochloride(GBR-12909dihydrochloride)
  • 67469-78-7
  • 67469-69-9
  • C28H34Cl2F2N2O
  • C28H32F2N2O2HCl
  • C28H32F2N2O2ClH
  • Dopamine receptor
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