ChemicalBook
Chinese english Germany Japanese Korea

Piperazin Produkt Beschreibung

Piperazine Struktur
110-85-0
CAS-Nr.
110-85-0
Bezeichnung:
Piperazin
Englisch Name:
Piperazine
Synonyma:
Upixon;Uvilon;Vermex;Antepan;Antiren;Eraverm;Pipersol;Worm-away;Lumbrical;Piperazin
CBNumber:
CB5852824
Summenformel:
C4H10N2
Molgewicht:
86.14
MOL-Datei:
110-85-0.mol

Piperazin Eigenschaften

Schmelzpunkt:
109-112 °C(lit.)
Siedepunkt:
146 °C
Dichte
1,1 g/cm3
Dampfdruck
0.8 mm Hg ( 20 °C)
Brechungsindex
1.4460
FEMA 
4250 | PIPERAZINE
Flammpunkt:
65 °C
storage temp. 
Store in dark!
Löslichkeit
H2O: 0.1 M at 20 °C, clear, colorless
pka
9.83(at 23℃)
Aggregatzustand
Crystalline Flakes
Farbe
White to slightly yellow
PH
11.0-12.5 (25℃, 0.1M in H2O)
Explosionsgrenze
14%
Wasserlöslichkeit
150 g/L (20 ºC)
Sensitive 
Air Sensitive & Hygroscopic
maximale Wellenlänge (λmax)
λ: 260 nm Amax: 0.035
λ: 280 nm Amax: 0.010
JECFA Number
1615
Merck 
14,7464
BRN 
102555
Stabilität:
Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
InChIKey
GLUUGHFHXGJENI-UHFFFAOYSA-N
CAS Datenbank
110-85-0(CAS DataBase Reference)
NIST chemische Informationen
Piperazine(110-85-0)
EPA chemische Informationen
Piperazine(110-85-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher C,Xn
R-Sätze: 34-42/43-52/53-62-52-63
S-Sätze: 22-26-36/37/39-45-61
RIDADR  UN 2579 8/PG 3
WGK Germany  1
RTECS-Nr. TK7800000
3-8-23
Hazard Note  Harmful/Corrosive
TSCA  Yes
HS Code  2933 59 95
HazardClass  8
PackingGroup  III
Giftige Stoffe Daten 110-85-0(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: 2600 mg/kg LD50 dermal Rabbit 8300 mg/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H314 Verursacht schwere Verätzungen der Haut und schwere Augenschäden. Ätzwirkung auf die Haut Kategorie 1B Achtung P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung P261, P285, P304+P341, P342+P311,P501
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.
P303+P361+P353 BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Piperazin Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

HYGROSKOPISCHE FARBLOSE KRISTALLEODER WEISSE FLOCKEN MIT STECHENDEM GERUCH.

CHEMISCHE GEFAHREN

Zersetzung beim Verbrennen unter Bildung giftiger und ätzender Gase mit Stickstoffoxiden. Mittelstarke Base in wässriger Lösung. Reagiert mit Säureanhydriden, starken Säurenund starken Oxidationsmitteln unter Feuergefahr. Greift viele Metalle unter Bildung brennbarer/explosionsfähiger Gase an (z.B. Wasserstoff, ICSC-Nr. 0001).

ARBEITSPLATZGRENZWERTE

TLV nicht festgelegt (ACGIH 2005).
MAK: IIb (nicht festgelegt, aber Informationen vorhanden); Sensibilisierung der Atemwege und der Haut (DFG 2006).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation und durch Verschlucken.

INHALATIONSGEFAHREN

Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz verätzt die Augen, die Haut und die Atemwege. ätzend beim Verschlucken. Inhalation der Substanz kann zu Lungenödem führen (s.Anm.). Möglich sind Auswirkungen auf das Nervensystem mit nachfolgenden Funktionsstörungenund Bewusstlosigkeit, wenn große Mengen verschluckt werden.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. Wiederholte oder andauernde Inhalation kann asthmatische Beschwerden hervorrufen.

LECKAGE

Belüftung. Verschüttetes Material in abgedeckten Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

R-Sätze Betriebsanweisung:

R34:Verursacht Verätzungen.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

Chemische Eigenschaften

Piperazine is white to cream-colored needles or powder. Characteristic ammonia-like odor. Combustible solids that do not easily ignite.

Chemische Eigenschaften

Colorless to yellow solid; salty taste.

Verwenden

Piperazine is used as an intermediate in themanufacture of dyes, pharmaceuticals, polymers,surfactants, and rubber accelerators.

Verwenden

Labelled Piperazine

Verwenden

keratolytic, antiseborheic

Definition

ChEBI: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.

Indications

Piperazine (Vermizine) contains a heterocyclic ring that lacks a carboxyl group. It acts on the musculature of the helminths to cause reversible flaccid paralysis mediated by chloride-dependent hyperpolarization of the muscle membrane. This results in expulsion of the worm. Piperazine acts as an agonist at gated chloride channels on the parasite muscle.
Piperazine has been used with success to treat A. lumbricoides and E. vermicularis infections, although mebendazole is now the agent of choice. Piperazine is administered orally and is readily absorbed from the intestinal tract. Most of the drug is excreted in the urine within 24 hours.
Piperazine is an appropriate alternative to mebendazole for the treatment of ascariasis, especially in the presence of intestinal or biliary obstruction. Cure rates of more than 80% are obtained following a 2-day regimen.
Side effects occasionally include gastrointestinal distress, urticaria, and dizziness. Neurological symptoms of ataxia, hypotonia, visual disturbances, and exacerbations of epilepsy can occur in patients with preexisting renal insufficiency. It should not be used in pregnant women because of the formation of a potentially carcinogenic and teratogenic nitrosamine metabolite. Concomitant use of piperazine and chlorpromazine or pyrantel should be avoided.

Trademarks

Pincets (Marion Merrell Dow); Pinsirup (Marion Merrell Dow);Adelmintex;Adipalis;Adipalit;Adiver;Ancaris thenium;Ancazine;Antelmina;Antepar (b-w);Anterobius;Anthalazine;Anthelmina;Anticucs;Antivermine;Ascalix;Ascarinex;Ascarivet;Asca-trol no.3;Asepar;Askaripar;Averamexan;Bel-zine;Bioxurin;B-piperazine;Brirel;Candizine;Carudol;Ciperazin;Citrazine;Coopane;Dak;Demovermil;Diatesurico;Dicevermin;Digesan;Dilaurazine;Dispermin;Diurazina;Dowzene;Ecosan;Endorid;Entazin;Equizole-a;Escovermin;Esteropipate;Etaphylline (acetyllinate);Gentiazina;Glycopiparsol;Heksapar;Helmacid;Helmezin;Helmicide;Helmifren;Helmipar;Helmirazine (adipate);Helmirazine (citrate);Helmitin;Helmizin;Herb royal round worm treatment;Hexanthelin;Ismiverm;Janes liquid permifu;Jarabe neox;Jetsan supp. (adipate);Justalmin;Kennel-maid;Kihomato;Kontipar;Lamboxil;Lombricida tropico;Lombrifher;Lombrikal;Lombrimade;Mapiprin;Maskito;Noxiurotan;Ogen;Okuside;Optiverm;Oxiril syrup (hydrate);Oxiuran (hydrate);Oxiurasin;Oxiustip elix;Oxivermin;Oxizin;Oxucid;Oxuril;Oxypip;Oxyzin;P.c. (citrate);Padrax;Paravermin;Pariamate;Par-tega;Perin;Piavermit;Pincide;Pipan;Pip-a-ray;Pipenin;Piperacid;Piperamicin;Piperascat;Piperaskat;Piperate;Piperaverm;Piperazinal;Piperazine (adipate);Pipercrean;Piperex;Piperiod;Piperital od;Piperitol;Piper-jodina;Piperol fort;Piperone;Piperoverm;Pipertox;Piperver;Piperzinal;Pipeverm;Pipezol;Pipizan citrate;Pipracid;Piprazid;Piprazyl;Pipricide;Piptelate;Piverma;Polo-verm;Polyquil;Pripsen;Provtovermil;Razinol;Rondelim;Rondoxyl;Santoban;Siropar;Supraverm;Taenifigin;Teniver;Tivazine;Toxocan;Uricida;Uridina;Uroclear (hexamine);Urodan (phosphate);Urosolvina;Uvilon syrup (hydrate);Vanpar (hydrate);Veripar;Vermazine;Vermenter;Vermicompren;Vermidol;Vermifug;Vermilass;Vermipan;Vermiphsarmette;Vermiquimpe;Vermiquimyc;Vermisit;Vermitox;Vermofrik;Verocid;Wairmex;Wurmex;Wurmsirup siegfried Multifuge;Multifuj;Nea-vermiol;Nemafugan;Nemasin;Nematocton;Nematorazine;Neo-ifusa;.

Weltgesundheitsorganisation (WHO)

Piperazine was first used as a treatment for gout earlier this century and its anthelminthic activity was discovered in 1949. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworm it has been withdrawn from use on the grounds that other more effective and less toxic drugs are now available (see full list). In other such countries, however, piperazine remains available in over-the-counter preparations. Clinical dosages occasionally induce transient neurological signs and concern has been expressed that in some circumstances the drug may generate small amounts of nitrosamine in the stomach. However, it is widely considered that these trace doses are unlikely to give rise to a significant carcinogenic potential. (Reference: (WHODIB) WHO Drug Information Bulletin, 1: 5, , 1983)

Allgemeine Beschreibung

Needle-like white or colorless crystals. Shipped as a solid or suspended in a liquid medium. Very corrosive to skin, eyes and mucous membranes. Solid turns dark when exposed to light. Flash point 190°F. Used as a corrosion inhibitor and as an insecticide.

Air & Water Reaktionen

Flammable. Absorbs water and carbon dioxide from air. Soluble in water.

Reaktivität anzeigen

1,4-Diazacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. 1,4-Diazacyclohexane is sensitive to light; 1,4-Diazacyclohexane absorbs water and carbon dioxide from air. 1,4-Diazacyclohexane may be corrosive to aluminum, magnesium and zinc. .

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Health Hazard

Piperazine is a corrosive substance. The solidand its concentrated aqueous solutions areirritants to the skin and eyes. The irritanteffect in rabbits’ eyes was severe.
The toxic symptoms from ingestion ofpiperazine include nausea, vomiting, excitement,change in motor activity, somnolence,and muscle contraction. The toxicity of thiscompound is low, however. The oral LD50value in rats is 1900 mg/kg. The inhalationtoxicity is very low. The inhalation LC50value in mice is 5400 mg/m3/2 h.

Brandgefahr

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Pharmazeutische Anwendungen

A synthetic chemical, most commonly formulated as the citrate, but also available as the adipate, edetate calcium and tartrate salts.

Kontakt-Allergie

Piperazine is contained in pyrazinobutazone, an equimolar salt of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory workers, in nurses, and in veterinarians.

Pharmakokinetik

Activity against intestinal worms requires that a substantial amount remains in the gut. However, after oral administration a variable amount is rapidly absorbed from the small intestine and subsequently excreted in the urine. Its half-life is extremely variable.

Clinical Use

Hexahydropyrazine or diethylenediamine (Arthriticine,Dispermin) occurs as colorless, volatile crystals of the hexahydratethat are freely soluble in water. After the discoveryof the anthelmintic properties of a derivative diethylcarbamazine,the activity of piperazine itself was established.Piperazine is still used as an anthelmintic for the treatmentof pinworm (Enterobius [Oxyuris] vermicularis) and roundworm(Ascaris lumbricoides) infestations. It is available invarious salt forms, including the citrate (official in the USP)in syrup and tablet forms. Piperazine blocks the response of the ascaris muscleto acetylcholine, causing flaccid paralysis in the worm,which is dislodged from the intestinal wall and expelled inthe feces.

Clinical Use

Ascariasis
Pinworm

Nebenwirkungen

Some people develop hypersensitivity, requiring cessation of treatment. Transient, mild gastrointestinal or neurological symptoms may occur.

Sicherheitsprofil

Moderately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Excessive absorption can cause urticaria, vomiting, diarrhea, blurred vision, and weakness. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Explodes on contact with dicyanofurazan. To fight fire, use alcohol foam, mist, dry chemical, water spray. When heated to decomposition it emits highly toxic fumes of NOx.

mögliche Exposition

(Piperazine): Primary irritant (w/o allergic reaction),

Veterinary Drugs and Treatments

Piperazine is used for the treatment of ascarids in dogs, cats, horses, swine and poultry. Piperazine is considered safe to use in animals with concurrent gastroenteritis and during pregnancy.

Versand/Shipping

UN2579 Piperazine, Hazard class: 8; Labels: 8-Corrosive material.

läuterung methode

Piperazine crystallises from EtOH or anhydrous *benzene and is dried at 0.01mm. It can be sublimed under vacuum and purified by zone melting. The hydrochloride has m 172-174o (from EtOH), and the dihydrochloride crystallises from aqueous EtOH and has m 318-320o (dec, sublimes at 295-315o). The picrate has m ~200o, and the picrolonate crystallises from dimethylformamide ( m 259-261o). [Beilstein 23 H 4, 23 I 4, 23 II 3, 23 III/IV 15, 23/1 V 30.]

Inkompatibilitäten

Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.

Piperazin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Piperazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 326)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 146 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8922 58

110-85-0(Piperazin)Verwandte Suche:


  • PIPERAZINE
  • 1,4-DIAZACYCLOHEXANE
  • AKOS 90646
  • AKOS BBS-00004315
  • HEXAHYDRO-1,4-DIAZINE
  • HEXAHYDROPYRAZINE
  • DIETHYLENEDIAMINE
  • Anhydrous Piperazine (PIP)
  • PIPERAZINE ANHYDROUS-FLAKES
  • PIPERAZINE REAGENTPLUS(TM) 99%
  • PIPERAZINE, REAGENTPLUS, 99%
  • PiperazineHydrateBp
  • Diethylenediamine (non-medicinal)
  • Piperazidine (non-medicinal)
  • Piperazine (non-medicinal)
  • Piperazine, extra pure, 99%
  • DIETHYLDIAMINE
  • Anhydrous ether
  • Piperazine Hexahydrtae
  • PIPRAZINE ANHYDROUS pure
  • Diethylene diamine anhydrous
  • 1,4-Diazacyclohexane, Diethylenediamine
  • PiperazineAnhydrous, ≥ 99.7% (GC)
  • Piperazine (anhydrous) Msynthplus
  • piperazine,anhydrous
  • Pipersol
  • Pyrazine hexahydride
  • Pyrazine, hexahydro-
  • pyrazinehexahydride
  • Upixon
  • Uvilon
  • Vermex
  • Worm-A-Ton
  • Worm-away
  • Wurmirazin
  • Trimetazidine Ipurity G
  • Piperazine, 99%, anhydrous
  • Pooerazine
  • Trimetazidine Impurity 7(Trimetazidine EP Impurity G)
  • 1,4-Diethylenediamine
  • 1,4-Piperazine
  • Antepan
  • Antiren
  • Asca-Trol No. 3
  • Diethyleneimine
  • Dispermine
  • Eraverm
  • Hexahydropyrazin
  • hexahydro-pyrazin
  • Lumbrical
  • Piperazidine
  • Piperazin
  • Piperazine, anhydrous
  • Piperazine,99%,extra pure
  • Piperazine ,99% [Extra dry]
  • Piperazine,1,4-Diazacyclohexane, Diethylenediamine
  • Piperzine Anhydrous
  • Piperazine (200 mg)
Copyright 2019 © ChemicalBook. All rights reserved