Pergolide mesylate salt
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- CAS-Nr.
- 66104-23-2
- Englisch Name:
- Pergolide mesylate salt
- Synonyma:
- MPE;Nopar;Permax;Celance;Veceral;Pergolin;ly127809;NSC 319773;PERGOLIDE MESYLATE;Pergolide mesilate CRS
- CBNumber:
- CB9455089
- Summenformel:
- C20H30N2O3S2
- Molgewicht:
- 410.59
- MOL-Datei:
- 66104-23-2.mol
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Pergolide mesylate salt Eigenschaften
- Schmelzpunkt:
- 252-254°C
- alpha
- aD20 between -18.0° and -23.0° (c = 10 mg/ml in DMF)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- ethanol: soluble2mg/mL
- pka
- pKa (66% DMF) 7.8(at 25℃)
- Aggregatzustand
- solid
- Farbe
- white
- Optische Aktivität
- [α]20/D 35°, c = 0.2 in pyridine(lit.)
- InChIKey
- UWCVGPLTGZWHGS-PLBOZXOQNA-N
- SMILES
- C12=C3C=CC=C1[C@@]1([H])C[C@H](CN(CCC)[C@]1([H])CC2=CN3)CSC.S(=O)(=O)(O)C |&1:6,9,15,r|
- CAS Datenbank
- 66104-23-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T+ |
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| R-Sätze: |
28 |
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| S-Sätze: |
28-36/37-45 |
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| RIDADR |
UN 1544 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
KE6345000 |
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| HS Code |
2939690000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizität oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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Pergolide mesylate salt Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Pergolide mesylate is a potent, long-acting dopamine agonist useful in the treatment of
Parkinson’s disease and hyperprolactinemia, Compared with lergotrile, pergolide mesylate
has shown less toxicity and lower propensity for inducing psychosis.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
A dopaminergic agonist that also decrease plasma prolactin concentrations. An antiparkinsonian agent
Definition
ChEBI: A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it i
used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.
Pergolide mesylate salt Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pergolide mesylate salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 152)Lieferanten
66104-23-2()Verwandte Suche:
- 8BETA-[(METHYLTHIO)METHYL]-6-PROPYLERGOLINE MESYLATE SALT
- 8-BETA-[(METHYLTHIO)METHYL]-6-PROPYLERGOLINE MONOMETHANE SULFONATE
- Pergolide mesylate EPIV
- Pergolidemetylsulfonate
- (8b)-8-[(Methylthio)methyl]-6-propylergoline Mesylate
- Celance
- Nopar
- Permax
- 8-alpha-Methylthiomethyl-6-pro
- 8β-[(methylthio)methyl]-6-propylergoline methanesulfonate salt
- Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8b)-, monomethanesulfonate (9CI)
- NSC 319773
- Pergolide methanesulfonate
- (8)-8-[(Methylthio)methyl]-6-propylergoline Mesylate
- Pergolide methanesulfonate salt, 8β-[(Methylthio)methyl]-6-propylergoline methanesulfonate salt
- Pergolin
- Veceral
- Pergolide methanesulfonate salt
- 8beta-[(Methylthio)methyl]-6-propylergoline methanesulfonate salt
- beta-((Methylthio)Methyl)-6-propylergolineMethanesulfonate
- Pergolide Mesylate, USP
- Pergolide Mesylate (200 mg)
- Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8β)-, monomethanesulfonate (9CI)
- (8beta)-8-[(methylthio)methyl]-6-propyl-Ergoline monomethanesulfonate (9CI)
- 8-beta-((methylthio)methyl)-6-propylergolinemethanesulfonate
- 8-beta-((methylthio)methyl)-6-propyl-ergolinmethanesulfonate(1:1)
- ly127809
- PERGOLIDE MESYLATE
- PERGOLIDE MESYLATE SALT
- MPE
- Pergolide mesilate CRS
- Pergolide mesylate salt, 98%, an antiparkinsonian agent which functions as a dopaminergic agonist
- (6aR,9R,10aR)-9-[(Methylsulfanyl)methyl]-7-propyl- 4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline monomethanesulfonate
- Pergolide mesylate salt USP/EP/BP
- Pergolide Mesylate (LY127809)
- Veterinary Drugs Pergolide mesylate salt
- Pergolide Mesylate (1510845)
- 66104-23-2
- C20H30N2O3S2
- C21H18N3O2
- C19H26N2SCH4O3S
- LOCOID
- API
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
