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ChemicalBook > Produktkatalog >Bio- und Chemieingenieurwesen >Inhibitoren >Immunsuppressiva >Tacrolimus

Tacrolimus Produkt Beschreibung

CAS-Nr.104987-11-3
Bezeichnung:
Englisch Name:Tacrolimus
Synonyma:
FK-506;prograf;Protopic;L 679934;Advagraf;fr900506;TacroBell;Fujimycin;Cacrolimus;TACROLIMUS
CBNumber:CB9772399
Summenformel:C44H69NO12
Molgewicht:804.02
MOL-Datei:104987-11-3.mol
Tacrolimus physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 113-115°C
Flammpunkt:: 2℃
storage temp. : −20°C
Löslichkeit: DMSO: >3 mg/mL
Aggregatzustand: solid
Farbe: white
Wasserlöslichkeit: Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
InChIKey: QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS Datenbank: 104987-11-3(CAS DataBase Reference)
Sicherheit
Kennzeichnung gefährlicher: T,Xi,Xn,F
R-Sätze:: 25-36/37/38-36-20/21/22-11
S-Sätze:: 45-36-26-36/37-16-60-20
RIDADR : UN 2811 6.1/PG 3
WGK Germany : 3
RTECS-Nr.: KD4201200
HazardClass : 6.1

Tacrolimus Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Tacrolimus, isolated from the microorganism Streptomyces tsukubaensis, is a macrolide immunosuppressant developed by Fujisawa for organ transplantation. It displays similar but more potent immunosuppressive activity than cyclosporin. It inhibits both cell mediated and humoral immune responses. In animal models of organ transplantation, tacrolimus has been shown to prolong survival of hepatic, renal, cardiac, small intestine, pancreatic and skin allografts and to reverse cardiac and renal allograft rejection. It has been used effectively in humans as rescue or primary immunosuppressant therapy in liver or kidney transplantation. Compared to cyclosporin, tacrolimus causes reduced incidence of infectious complications and of hypertension and hypercholesterolemia for the allograft recipients. In common with cyclosporin, tacrolimus binds with high affinity to a family of cytoplasmic immunosuppressant binding proteins, the immunophilins. This tight complex is proposed as the biologically active moiety that interacts with intracellular molecules involved in signal transduction.It inhibits phosphatase activity of calcineurin, an action that may impair the generation and/or activation of nuclear transcription factors required for lymphokine (particularly interleukin-2) gene expression. Tacrolimus has also been reported to have potential in multiple sclerosis, psoriasis, rheumatoid arthritis and uveitis associated with Behcet‘s disease.
Chemische Eigenschaften
White Crystalline Solid
Originator
Fujisawa (Japan)
Verwenden
An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Verwenden
FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
Verwenden
Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.
Verwenden
treatment of Cushing's syndrome
Verwenden
For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart,
Definition
ChEBI: Tacrolimus is a macrolide containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.
Trademarks
Prograf (Astellas); Protopic (Astellas).
Tacrolimus Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Ethylacetat Strke Hefe, Extrakt
Downstream Produkte
Tacrolimus Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 389)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20743 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95sales@capotchem.com China 19947 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 274 58
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32606 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688bruce@xrdchem.cn CHINA 548 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122sales@fine-chemtech.com CHINA 893 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796ivan@atkchemical.com CHINA 24212 60
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 495 55
Meihua Biological Technology Co.,Ltd
15175972705
031145896235sales@hbmeihua.cn CHINA 213 58
 
104987-11-3(Tacrolimus)Verwandte Suche:
Tetrahydro-2-(2-propinyloxy)-2H-pyran Ethyl-1-methylpiperidin-2-carboxylat 1-Pentylallylbutyrat 1-Piperidinoaceton (R)-Piperidin-2-carbonsure N-Lauroylsarkosin Ethylpiperidin-2-carboxylat N,N-Diethyldodecanamid
(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s* ,19s*,26ar*))- 16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]- L 679934 Protopic FK-506:FR-900506 Fujimycin Prozraf Tacrolimus,micronisedandpharmagrade REF DUPL: Tacrolimus FK506(Tacrolimus) Tacrolimus premix Cacrolimus FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-Methoxycyclohexyl]prop-1-en-2-yl]-23,25-diMethoxy-13,19,21,27-tetraMethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10 Advagraf TacroBell TacroliMus-13CD2/FK-506-13CD2 FujiMycin, FK506, FR900506, Tskubaenolide 19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim 6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5 fr900506 prograf tsukubaenolide TACROLIMUS FK-506 FK-506, 99+% Fujimycin - Active Pharmaceutical Ingredients Immunosuppressant. Intermediates & Fine Chemicals Pharmaceuticals API Chiral Reagents Fujimycin, Prograf antibiotic C44H69NO12xH2O (3S,4R,5S,8R,9E...5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e Tacrolimus solution tacrolimus (anhydrous) Tacrolimus, Prograf, FK506 Tacrolimus, 98.5% Inhibitors 104987-11-3 ;109581-93-3 104987-11-3 109581-93-9 C44H69NO12 C44H69NO10 Kinase/Phosphatase Biology Protein Phosphatase 2B (Calcineurin/PP2B) Serine/Threonine Phosphatase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience
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