Tacrolimus

Tacrolimus 구조식 이미지
카스 번호:
104987-11-3
상품명:
Tacrolimus
동의어(영문):
FK-506;prograf;Protopic;Tacrolimus premix;Tacrolimus reference;imus);Tacros;CS-1172;Advagraf;L 679934
CBNumber:
CB9772399
분자식:
C44H69NO12
포뮬러 무게:
804.02
MOL 파일:
104987-11-3.mol
MSDS 파일:
SDS

Tacrolimus 속성

녹는점
113-115°C
끓는 점
871.7±75.0 °C(Predicted)
밀도
1.19±0.1 g/cm3(Predicted)
인화점
2℃
저장 조건
Sealed in dry,Store in freezer, under -20°C
용해도
DMSO: >3mg/mL
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
9.97±0.70(Predicted)
색상
하얀색
수용성
DMSO 또는 에탄올에 자유롭게 용해됩니다. 물에 잘 녹지 않습니다. 디메틸 설폭시드, 에탄올, 물, 아세톤, 클로로포름, 에틸 아세테이트, 에테르, 메탄올 및 디메틸 포름아미드에 용해됩니다.
BCS Class
2
안정성
제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 2개월 동안 보관할 수 있습니다.
InChIKey
QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS 데이터베이스
104987-11-3(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,Xi,Xn,F
위험 카페고리 넘버 25-36/37/38-36-20/21/22-11
안전지침서 45-36-26-36/37-16-60-20
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 3
RTECS 번호 KD4201200
위험 등급 6.1
HS 번호 29349990
유해 물질 데이터 104987-11-3(Hazardous Substances Data)
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
예방조치문구:
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
NFPA 704
0
2 0

Tacrolimus C화학적 특성, 용도, 생산

개요

Tacrolimus, isolated from the microorganism Streptomyces tsukubaensis, is a macrolide immunosuppressant developed by Fujisawa for organ transplantation. It displays similar but more potent immunosuppressive activity than cyclosporin. It inhibits both cell mediated and humoral immune responses. In animal models of organ transplantation, tacrolimus has been shown to prolong survival of hepatic, renal, cardiac, small intestine, pancreatic and skin allografts and to reverse cardiac and renal allograft rejection. It has been used effectively in humans as rescue or primary immunosuppressant therapy in liver or kidney transplantation. Compared to cyclosporin, tacrolimus causes reduced incidence of infectious complications and of hypertension and hypercholesterolemia for the allograft recipients. In common with cyclosporin, tacrolimus binds with high affinity to a family of cytoplasmic immunosuppressant binding proteins, the immunophilins. This tight complex is proposed as the biologically active moiety that interacts with intracellular molecules involved in signal transduction.It inhibits phosphatase activity of calcineurin, an action that may impair the generation and/or activation of nuclear transcription factors required for lymphokine (particularly interleukin-2) gene expression. Tacrolimus has also been reported to have potential in multiple sclerosis, psoriasis, rheumatoid arthritis and uveitis associated with Behcet‘s disease.

화학적 성질

White Crystalline Solid

용도

FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system

정의

ChEBI: Tacrolimus is a macrolide containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.

Indications

Tacrolimus is a macrolide lactone originally derived from Streptomyces tsukubaensis. Although structurally unrelated to cyclosporine, tacrolimus has a very similar mechanism of action; that is, it blocks the production of proinflammatory cytokines by T lymphocytes by inhibiting calcineurin.Tacrolimus, however, appears to be 10 to 100 times as potent as an immunosuppressive. Oral tacrolimus (FK506) is used for prevention of organ rejection in recipients of renal and hepatic transplants.

일반 설명

Immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 Binding Protein, thereby reversing its effects on sarcoplamic reticulum Ca2+ release. Shown to inhibit the Ca2+-dependent phosphatase, Calcineurin (Cat. No. 539565), as well as Na+-K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.

Clinical Use

A topical formulation (Protopic) has recently been approved for treatment of moderate to severe atopic dermatitis in children and adults who have not responded to other therapies. Levels of systemic absorption are low even when applied to a relatively large body surface area.

부작용

Local irritant reactions (burning, stinging, erythema) are a common side effect, but these usually resolve within the first few days of treatment. The major benefit of topical tacrolimus over topical corticosteroids is that tacrolimus does not cause atrophy, striae, or telangiectasia, even with chronic use.

Tacrolimus 준비 용품 및 원자재

원자재

준비 용품


Tacrolimus 공급 업체

글로벌( 659)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Hangzhou Benoy Chemical Co., Ltd
+8617342059697
sales@benoychem.com China 315 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10326 58
Shanghai Minbiotech Co., Ltd.
+8617315815539
sales@minbiotech.com CHINA 129 58
Jiangxi Huihe Chemical Co., Ltd.
+86-19189228086 +8618858568638
wuzhouding@huihecrop.com China 886 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21703 55
Xi’an Sengmei Biotech Co.,Ltd.
+8615398038360
lionel@accenturebio.com China 288 58
Shanghai Chinqesen Biotechnology Co., Ltd.
+86-16628886292 +86-19521323435
sales2@qschem-pharma.com China 253 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5960 58
Hebei Dangtong Import and export Co LTD
+8615632927689
admin@hbdangtong.com China 1000 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60

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