Tacrolimus
|
|
Tacrolimus 속성
- 녹는점
- 113-115°C
- 끓는 점
- 871.7±75.0 °C(Predicted)
- 밀도
- 1.19±0.1 g/cm3(Predicted)
- 인화점
- 2℃
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO: >3mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 9.97±0.70(Predicted)
- 색상
- 하얀색
- optical activity
- +62.223 (CHCl3)
- 수용성
- DMSO 또는 에탄올에 자유롭게 용해됩니다. 물에 잘 녹지 않습니다. 디메틸 설폭시드, 에탄올, 물, 아세톤, 클로로포름, 에틸 아세테이트, 에테르, 메탄올 및 디메틸 포름아미드에 용해됩니다.
- BCS Class
- 2
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 2개월 동안 보관할 수 있습니다.
- InChIKey
- QJJXYPPXXYFBGM-LFZNUXCKSA-N
- CAS 데이터베이스
- 104987-11-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xi,Xn,F | ||
---|---|---|---|
위험 카페고리 넘버 | 25-36/37/38-36-20/21/22-11 | ||
안전지침서 | 45-36-26-36/37-16-60-20 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | KD4201200 | ||
위험 등급 | 6.1 | ||
HS 번호 | 29349990 | ||
유해 물질 데이터 | 104987-11-3(Hazardous Substances Data) |
Tacrolimus C화학적 특성, 용도, 생산
개요
Tacrolimus, isolated from the microorganism Streptomyces tsukubaensis, is a macrolide immunosuppressant developed by Fujisawa for organ transplantation. It displays similar but more potent immunosuppressive activity than cyclosporin. It inhibits both cell mediated and humoral immune responses. In animal models of organ transplantation, tacrolimus has been shown to prolong survival of hepatic, renal, cardiac, small intestine, pancreatic and skin allografts and to reverse cardiac and renal allograft rejection. It has been used effectively in humans as rescue or primary immunosuppressant therapy in liver or kidney transplantation. Compared to cyclosporin, tacrolimus causes reduced incidence of infectious complications and of hypertension and hypercholesterolemia for the allograft recipients. In common with cyclosporin, tacrolimus binds with high affinity to a family of cytoplasmic immunosuppressant binding proteins, the immunophilins. This tight complex is proposed as the biologically active moiety that interacts with intracellular molecules involved in signal transduction.It inhibits phosphatase activity of calcineurin, an action that may impair the generation and/or activation of nuclear transcription factors required for lymphokine (particularly interleukin-2) gene expression. Tacrolimus has also been reported to have potential in multiple sclerosis, psoriasis, rheumatoid arthritis and uveitis associated with Behcet‘s disease.화학적 성질
White Crystalline Solid용도
FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system정의
ChEBI: Tacrolimus is a macrolide containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.Indications
Tacrolimus is a macrolide lactone originally derived from Streptomyces tsukubaensis. Although structurally unrelated to cyclosporine, tacrolimus has a very similar mechanism of action; that is, it blocks the production of proinflammatory cytokines by T lymphocytes by inhibiting calcineurin.Tacrolimus, however, appears to be 10 to 100 times as potent as an immunosuppressive. Oral tacrolimus (FK506) is used for prevention of organ rejection in recipients of renal and hepatic transplants.일반 설명
Immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 Binding Protein, thereby reversing its effects on sarcoplamic reticulum Ca2+ release. Shown to inhibit the Ca2+-dependent phosphatase, Calcineurin (Cat. No. 539565), as well as Na+-K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.Clinical Use
A topical formulation (Protopic) has recently been approved for treatment of moderate to severe atopic dermatitis in children and adults who have not responded to other therapies. Levels of systemic absorption are low even when applied to a relatively large body surface area.부작용
Local irritant reactions (burning, stinging, erythema) are a common side effect, but these usually resolve within the first few days of treatment. The major benefit of topical tacrolimus over topical corticosteroids is that tacrolimus does not cause atrophy, striae, or telangiectasia, even with chronic use.Tacrolimus 준비 용품 및 원자재
원자재
준비 용품
Tacrolimus 공급 업체
글로벌( 673)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hangzhou Benoy Chemical Co., Ltd | +8617342059697 |
sales@benoychem.com | China | 315 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Shanghai Minbiotech Co., Ltd. | +8617315815539 |
sales@minbiotech.com | CHINA | 129 | 58 |
Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 |
wuzhouding@huihecrop.com | China | 886 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24099 | 58 |
Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 |
hanson@sdhanjiang.com | China | 1000 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5872 | 58 |
Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 |
admin@hbdangtong.com | China | 1005 | 58 |
Tacrolimus 관련 검색:
라우로일사르코신
Tacrolimus Monohydrate
D(+)-Pipecolinic acid
N-Dodecanoyl-L-alanine
Tacrolimus
H-HOMOPRO-OME HCL
Ethyl pipecolinate
N,N-Diethyldodecanamide
Ethyl1-butyl-2-piperidinecarbxylate
Ascomycin
2-(TETRAHYDRO-PYRAN-2-YL)-ETHYLAMINE
N-LAUROYL-L-ALANINE
1-methyl-piperidine-2-carboxylicacidmethylester
1-OCTEN-3-YL BUTYRATE
Ethyl 1-methylpipecolinate
Pimecrolimus
TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
1-ACETYL-2-PIPERIDINECARBOXYLIC ACID