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Fluorexon

Fluorexon
Fluorexon structure
CAS No.
1461-15-0
Chemical Name:
Fluorexon
Synonyms
CALCEIN;CALCEINE;FLUOREXON;FLUREXONE;N,N'-[[3';FLUOREXONE;Oftasceine;oftasccine;Nsc 298193;CALCEIN(RG)
CBNumber:
CB0146553
Molecular Formula:
C30H26N2O13
Formula Weight:
622.53
MOL File:
1461-15-0.mol

Fluorexon Properties

Melting point:
200 °C
Boiling point:
662.7°C (rough estimate)
Density 
1.4388 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: soluble
form 
Powder
pka
6.67(at 25℃)
color 
Yellow-orange to orange-brown
PH Range
Weak green ' uorescence (6.0) to strong green ' uorescence (7.2)
Water Solubility 
insoluble
λmax
494nm
Stability:
Stable. Incompatible with strong oxidizing agents.
Biological Applications
Calcium indicator; fluoride indicator; iron indicator; mercury indicator; detecting nucleic acids,proteins; treating osteoporosis; drug delivery systems
Major Application
Chemical-mechanical polishing, stabilizing liposomes, cell motility assay, detecting nucleic acids, virus, screening safety of gastric mucosa, MDR inhibitors, delivery, imaging atherosclerotic plaque
CAS DataBase Reference
1461-15-0(CAS DataBase Reference)
FDA UNII
V0YM2B16TS
EPA Substance Registry System
Glycine, N,N'-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl)bis(methylene)]bis[N-(carboxymethyl)- (1461-15-0)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36/37/39-26
WGK Germany  3
10
HS Code  32041900

Fluorexon price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0875 Calcein Used for the fluorometric determination of calcium and EDTA titration of calcium in the presence of magnesium. 1461-15-0 5 g $159 2021-03-22 Buy
Sigma-Aldrich 1.02315 Calcein indicator for metal determination 1461-15-0 1023150005 $178 2020-08-18 Buy
Sigma-Aldrich 1.02315 Calcein indicator for metal determination 1461-15-0 5 g $181.3 2021-03-22 Buy
Sigma-Aldrich C0875 Calcein Used for the fluorometric determination of calcium and EDTA titration of calcium in the presence of magnesium. 1461-15-0 10 g $294 2021-03-22 Buy
Sigma-Aldrich C0875 Calcein Used for the fluorometric determination of calcium and EDTA titration of calcium in the presence of magnesium. 1461-15-0 25 g $648 2021-03-22 Buy

Fluorexon Chemical Properties,Uses,Production

Chemical Properties

orange crystals

Uses

Calcein is used for determination of Ca in biological systems. Indicator for the fluorimetric determination of calcium in presence of Mg by complexometric titration.

Uses

Calcein is a anthene that is commonly used for the fluorometric determination of calcium in solution. As this form of calcein is not membrane permeable, it can be used in assays that evaluate membrane integrity. Calcein can also be used as a fluorescent indicator for fluoride, iron, and mercury. [Cayman Chemical]

Purification Methods

Dissolve it in distilled H2O and acidify with dilute HCl to pH 3.5. Filter off the solid acid and wash it well with H2O. Redissolve ca 10g in 300mL H2O containing 12g of NaOAc. Precipitate it again by adding HCl, filtering and washing with H2O. Add the solid to 200mL of EtOH stir for 1hour and filter. Repeat the EtOH wash and dry the bright yellow solid in a vacuum. This acid decomposes on heating at ca 180o. See below for the preparation of the Na salt. [Diehl & Ellingboe Anal Chem 28 882 1956]. Altenatively dissolve it in H2O and acidify with 3N HCl to pH 3.5. Collect the solid and wash it with H2O. The air-dried precipitate is extracted with 70% aqueous EtOH, filtered hot and cooled slowly. Fine yellow needles of the acid crystallise out; they are filtered off and dissolved in the minimum quantity of 0.01N NaOH and re-precipitated by adding N HCl to pH 3.5. It is then recrystallised from 70% aqueous EtOH (3x). The final product (acid) is dried at 80o in a vacuum for 24hours, m >300o(dec). It contains one molecule of water per molecule of acid (C30H36N4O13.H2O). The product is pure as revealed by electrophoresis at pH 5.6 and 8.6, and by TLC in i-BuOH/i-PrOH/AcOH/H2O (60:60:5:5 by volume) or i-PrOH or pH 8.0 borate buffer. [Wallach et al. Anal Chem 31 456 1959.] The Na salt is prepared by dissolving the pure acid in H2O containing 2 mols of NaOH per mol of acid reagent and lyophilising. It complexes with Ca and Mg ions. [Beilstein 19 III/IV 4338.]

Fluorexon Preparation Products And Raw materials

Raw materials

Preparation Products


Fluorexon Suppliers

Global( 267)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Career Henan Chemica Co
13203830695 0371-86658258
0371-86658258 Laboratory@coreychem.com CHINA 30281 58

View Lastest Price from Fluorexon manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-11 Fluorexon
1461-15-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06 Fluorexon
1461-15-0
US $1.00 / KG 1G 99% 100KG career henan chemical co

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