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Fluorexon

Fluorexon
Fluorexon
CAS No.
1461-15-0
Chemical Name:
Fluorexon
Synonyms
CALCEIN;CALCEINE;FLUOREXON;FLUREXONE;Nsc 298193;FLUOREXONE;Oftasceine;oftasccine;CALCEIN(RG);CALCEIN, INDICATOR
CBNumber:
CB0146553
Molecular Formula:
C30H26N2O13
Formula Weight:
622.54
MOL File:
1461-15-0.mol

Fluorexon Properties

Melting point:
200 °C
Boiling point:
662.7°C (rough estimate)
Density 
1.4388 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: soluble
form 
Powder
pka
6.67(at 25℃)
color 
Yellow-orange to orange-brown
PH Range
Weak green ' uorescence (6.0) to strong green ' uorescence (7.2)
Water Solubility 
insoluble
λmax
494nm
Stability:
Stable. Incompatible with strong oxidizing agents.
Biological Applications
Calcium indicator; fluoride indicator; iron indicator; mercury indicator; detecting nucleic acids,proteins; treating osteoporosis; drug delivery systems
Major Application
Chemical-mechanical polishing, stabilizing liposomes, cell motility assay, detecting nucleic acids, virus, screening safety of gastric mucosa, MDR inhibitors, delivery, imaging atherosclerotic plaque
CAS DataBase Reference
1461-15-0(CAS DataBase Reference)
EPA Substance Registry System
Glycine, N,N'-[(3',6'- dihydroxy-3-oxospiro[isobenzofuran- 1(3H),9'-[9H]xanthene]- 2',7'-diyl)bis( methylene)]bis[N-(carboxymethyl)- (1461-15-0)

SAFETY

Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36/37/39-26
WGK Germany  3
10
HS Code  32041900

Fluorexon price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1.02315 Calcein indicator for metal determination 1461-15-0 1023150005 $169 2018-11-23 Buy
Cayman Chemical 16221 Calcein 1461-15-0 1g $25 2018-11-13 Buy
Cayman Chemical 16221 Calcein 1461-15-0 5g $44 2018-11-13 Buy
Cayman Chemical 16221 Calcein 1461-15-0 10g $75 2018-11-13 Buy
Cayman Chemical 16221 Calcein 1461-15-0 25g $138 2018-11-13 Buy

Fluorexon Chemical Properties,Uses,Production

Chemical Properties

orange crystals

Uses

Calcein is used for determination of Ca in biological systems. Indicator for the fluorimetric determination of calcium in presence of Mg by complexometric titration.

Uses

Calcein is a xanthene that is commonly used for the fluorometric determination of calcium in solution. As this form of calcein is not membrane permeable, it can be used in assays that evaluate membrane integrity. Calcein can also be used as a fluorescent indicator for fluoride, iron, and mercury. Absorption and emission maxima for calcein are 494 and 517 nm, respectively.[Cayman Chemical]

Purification Methods

Dissolve it in distilled H2O and acidify with dilute HCl to pH 3.5. Filter off the solid acid and wash it well with H2O. Redissolve ca 10g in 300mL H2O containing 12g of NaOAc. Precipitate it again by adding HCl, filtering and washing with H2O. Add the solid to 200mL of EtOH stir for 1hour and filter. Repeat the EtOH wash and dry the bright yellow solid in a vacuum. This acid decomposes on heating at ca 180o. See below for the preparation of the Na salt. [Diehl & Ellingboe Anal Chem 28 882 1956]. Altenatively dissolve it in H2O and acidify with 3N HCl to pH 3.5. Collect the solid and wash it with H2O. The air-dried precipitate is extracted with 70% aqueous EtOH, filtered hot and cooled slowly. Fine yellow needles of the acid crystallise out; they are filtered off and dissolved in the minimum quantity of 0.01N NaOH and re-precipitated by adding N HCl to pH 3.5. It is then recrystallised from 70% aqueous EtOH (3x). The final product (acid) is dried at 80o in a vacuum for 24hours, m >300o(dec). It contains one molecule of water per molecule of acid (C30H36N4O13.H2O). The product is pure as revealed by electrophoresis at pH 5.6 and 8.6, and by TLC in i-BuOH/i-PrOH/AcOH/H2O (60:60:5:5 by volume) or i-PrOH or pH 8.0 borate buffer. [Wallach et al. Anal Chem 31 456 1959.] The Na salt is prepared by dissolving the pure acid in H2O containing 2 mols of NaOH per mol of acid reagent and lyophilising. It complexes with Ca and Mg ions. [Beilstein 19 III/IV 4338.]

Fluorexon Preparation Products And Raw materials

Raw materials

Preparation Products


Fluorexon Suppliers

Global( 186)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19990 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40395 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 sales@hwrkchemical.com China 14615 55
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44187 61
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 14014 59

View Lastest Price from Fluorexon manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-13 Fluorexon
1461-15-0
US $1.00 / KG 1G 99% 100KG career henan chemical co

1461-15-0(Fluorexon)Related Search:


  • 2,2',2'',2'''-(((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-2',7'-diyl)bis(Methylene))bis(azanetriyl))tetraacetic acid
  • Calcein indicator for metal determination
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  • Biochemicals and Reagents
  • BioChemical
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  • Detection
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