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Loperamide

Loperamide
Loperamide structure
CAS No.
53179-11-6
Chemical Name:
Loperamide
Synonyms
C07080;Tebloc;utanamide;LOPERAMIDE;4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide;4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-2,2-diphenyl-N,N-dimethylbutyramide;4-[4-Chlorophenyl]-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutanamide;4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide
CBNumber:
CB7402928
Molecular Formula:
C29H33ClN2O2
Formula Weight:
477.04
MOL File:
53179-11-6.mol

Loperamide Properties

pka
pKa 8.66(H2O) (Uncertain)
CAS DataBase Reference
53179-11-6(CAS DataBase Reference)
NIST Chemistry Reference
Loperamide(53179-11-6)

SAFETY

Loperamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

Loperamide Chemical Properties,Uses,Production

Definition

ChEBI: A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

brand name

Ami-29;Colifelin;Colifilm;Diareze;Dissenter;Duplibiot;Elcoman;Firtasec;Loperan;Loperin;Lopermid;Motilix;Orulop;Pf 185;Pricilone;R-18553;Regulane;Seldiar;Taguinol;Telboc;Totrtasec.

World Health Organization (WHO)

Loperamide, an inhibitor of intestinal peristalsis, was introduced in 1975 for the treatment of acute and chronic diarrhoea. In many countries its use was discouraged in young children. In late 1989, treatment of infants in Pakistan was associated with 19 cases of paralytic ileus, 6 of which have been fatal. This has subsequently led the major manufacturer to withdraw all drop formulations of the drug worldwide as well as the lower dose syrup forms from countries where there is a programme for the control of diarrhoeal diseases. The WHO Control of Diarrhoeal Diseases Programme recommends that loperamide should not be used in children below five year of age. (Reference: (LJJ) Letter to WHO from Johnson & Johnson, , , 21 June 1990)

General Description

Loperamide (Imodium) is a 4-phenylypiperidine with amethadone-like structure attached to the piperidine nitrogen. It acts as an antidiarrheal by directly binding tothe opiate receptors in the gut wall. Loperamide inhibitsacetylcholine and prostaglandin release, decreasing peristalsisand fluid secretion thus increasing the GI transit time andreducing the volume of fecal matter.Loperamide is sufficiently lipophilic to cross the blood-brain barrier, yet itdisplays no CNS-opioid effects. The reason for this is that itis actively pumped out of the brain via the P-glycoproteinpump (MDR1). Knockout mice with the P-glycoproteinpump genetically removed were given radiolabeled loperamideand sacrificed 4 hours later. The [3H]loperamideconcentrations were measured and compared with wild-typemice. A 13.5-fold increase in loperamide concentration wasfound in the brain of the knockouts. In addition, the micelacking the P-glycoprotein pump displayed pronouncedsigns of central opiate agonism. Loperamide is availableas 2-mg capsules for treatment of acute and chronic diarrhea.Recommended dosage is 4 mg initially, with 2 mgafter each loose stool for a maximum of 16 mg/d.

Loperamide Preparation Products And Raw materials

Raw materials

Preparation Products


Loperamide Suppliers

Global( 39)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1954 70
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13074 57
Jinan Haohua Industry Co., Ltd 0531-58773082 ;58773060
0531-58773099 sales@jnhaohua.com China 5621 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12388 58
Jintan WeiDeLong Chemical Co., Ltd. 0519-82805025;82196959;13616137378
0519-82805025 wangqiangcz@126.com China 4235 58
Guangzhou Kafen Biotech Co.,Ltd 18029243487 QQ:2355327168
020-31121510 gy@yccreate.com China 4875 55
Xiangtan Jiayeyuan Biotechnology Co., Ltd. 18973261526
0731-55570935 fiona1@yccreate.com China 6902 58

View Lastest Price from Loperamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-15 Loperamide
53179-11-6
US $1.00 / KG 1G 98% 100KG career henan chemical co

53179-11-6(Loperamide)Related Search:


  • LOPERAMIDE
  • 4-[4-Chlorophenyl]-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutanamide
  • 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide
  • 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide
  • 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-di(phenyl)butanamide
  • Tebloc
  • 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide
  • 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-2,2-diphenyl-N,N-dimethylbutyramide
  • 4-[4-Hydroxy-4-(4-chlorophenyl)-1-piperidinyl]-2,2-diphenyl-N,N-dimethylbutanamide
  • C07080
  • 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N DIMETHYL-A,A DIPHENYL-1-PEIPERIDINE BUTANAMIDEHCL
  • 4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb
  • utanamide
  • 53179-11-6
  • C29H33ClN2O2
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