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CARBENICILLIN

Brand Name(s) in US
CARBENICILLIN
CARBENICILLIN structure
CAS No.
4697-36-3
Chemical Name:
CARBENICILLIN
Synonyms
Pyocianil;onamic acid;CARBENICILLIN;Carboxybenzylpenicillin;CARBENICILLIN READY MADE;Carbenicillinum natricum;(α-Carboxybenzyl)penicillin;Carboxybenzylpenicillin acid;ALPHA-CARBOXYBENZYLPENICILLIN;carbenicillin ada@tuskwei.com sky
CBNumber:
CB0243304
Molecular Formula:
C17H18N2O6S
Formula Weight:
378.4
MOL File:
4697-36-3.mol

CARBENICILLIN Properties

storage temp. 
−20°C
pka
pKa 2.22±0.05(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);3.25±0.02 (Uncertain)
CAS DataBase Reference
4697-36-3

SAFETY

Hazard Codes  Xn
Risk Statements  10-42/43
Safety Statements  36/37-45-22
RIDADR  UN 1170 3/PG 3
WGK Germany  2

CARBENICILLIN price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

CARBENICILLIN Chemical Properties,Uses,Production

Brand Name(s) in US

Carbenicillin: Geopen, Pyopen
Carbenicillin indanyl sodium: Geocillin

Uses

Antibacterial.

Definition

ChEBI: A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain.

brand name

Geopen (Roerig); Pyopen (GlaxoSmithKline).

Antimicrobial activity

α-Carboxybenzylpenicillin; the first antipseudomonal penicillin to be developed. A semisynthetic carboxypenicillin supplied as the disodium salt for parenteral administration. The two esterified prodrug formulations, carindacillin (carbenicillin indanyl sodium) and carfecillin (carbenicillin carboxyphenyl ester) are no longer available.
It is the least active of the group 5 agents, even against Ps. aeruginosa (MIC 64 mg/L) with notably reduced activity against Gram-positive cocci. It is labile to many plasmidmediated β-lactamases, but is comparatively stable to class C chromosomal β-lactamases (pp. 228–230). Synergy is demonstrable with aminoglycosides against Ps. aeruginosa and other Gram-negative bacteria.
It is not orally absorbed, except in esterified form. A 1 g intramuscular injection achieves a plasma peak concentration of 20–30 mg/L after 0.5–1.5 h. The half-life is around 1 h. Plasma protein binding is 50–60%.
The drug is distributed in the extracellular fluid, providing concentrations up to 60% of those of the plasma. In patients with cystic fibrosis sputum concentrations may not reach inhibitory levels for Ps. aeruginosa. It does not cross the normal meninges but levels of up to 50% of those of the plasma can be found in patients with meningitis. Around 80% of the dose appears as unchanged drug in the urine, producing very high levels (2–4 g/L). It is more rapidly disposed of in patients with cystic fibrosis. Hypersensitivity reactions may occur, but these are less frequent and severe than those associated with benzylpenicillin. High blood levels sometimes cause a coagulation defect that has occasionally progressed to life-threatening bleeding in patients with impaired excretion while receiving 500 mg/kg per day or more. Reversible abnormalities of liver function apparently occur more commonly than with other antipseudomonal penicillins. Since large doses of the drug have to be used, convulsions can occur (as with other penicillins; p. 203) and, being administered as the disodium salt, electrolyte disturbances can result. It was formerly used for treatment of serious infections, especially those involving Ps. aeruginosa. It has extremely limited availability.

CARBENICILLIN Preparation Products And Raw materials

Raw materials

Preparation Products


CARBENICILLIN Suppliers

Global( 27)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 sales@ouhechem.com China 12598 60
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9947 55
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12388 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
020-39119999 isunpharm@qq.com, isunpharm@hotmail.com China 5029 55
Alfa Chemistry 1-201-478-8534
1-516-927-0118 inquiry@alfa-chemistry.com United States 9985 60
Shanghai Synchem Pharma Co., ltd +86-21-61984905 ext 1、ext 2 、+86-18016477331
+86-(21)-58010681 synchempharma@126.com China 5220 55
ShangHai Biochempartner Co.,Ltd 13720134139
candy@biochempartner.com China 4982 62

4697-36-3(CARBENICILLIN)Related Search:


  • ALPHA-CARBOXYBENZYLPENICILLIN
  • CARBENICILLIN READY MADE
  • CARBENICILLIN
  • (α-Carboxybenzyl)penicillin
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxyphenylacetyl)amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxyphenylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
  • 6-(α-Carboxyphenylacetamido)penicillanic acid
  • Carboxybenzylpenicillin
  • Carboxybenzylpenicillin acid
  • Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenyl- (7CI, 8CI)
  • Pyocianil
  • Carbenicillinum natricum
  • onamic acid
  • Carbenicillin (base and/or unspecified salts)
  • N-[(2S,5R,6R)-2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl]-2-phenylmalonamidic acid
  • 6-(alpha-Carboxyphenylacetamido)penicillanic acid
  • carbenicillin ada@tuskwei.com sky
  • 4697-36-3
  • C17H18N2O6S
  • carbenicillin sky
  • 18031153937@189.cn
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