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Notoginsenoside Ft1

Notoginsenoside Ft1 Structure
Notoginsenoside Ft1 structure
CAS No.
155683-00-4
Chemical Name:
Notoginsenoside Ft1
Synonyms
product/153944;Notoginsenoside Ft1;Notoginsenoside Ft1, 10 mM in DMSO;β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)-;(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl O-beta-D-xylopyranosyl-(1- 2)-O-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside;(2S,3R,4S,5R)-2-[(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
CBNumber:
CB02535807
Molecular Formula:
C47H80O17
Molecular Weight:
917.13
MDL Number:
MFCD22125013
MOL File:
155683-00-4.mol
Last updated:2025-04-18 09:51:28
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Notoginsenoside Ft1 Properties

Boiling point 997.8±65.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
solubility DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid
pka 12.84±0.70(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

Notoginsenoside Ft1 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24976 Notoginsenoside Ft1 ≥95% 155683-00-4 1mg $26 2024-03-01 Buy
Cayman Chemical 24976 Notoginsenoside Ft1 ≥95% 155683-00-4 500μg $32 2023-01-06 Buy
Cayman Chemical 24976 Notoginsenoside Ft1 ≥95% 155683-00-4 5mg $83 2024-03-01 Buy
Cayman Chemical 24976 Notoginsenoside Ft1 ≥95% 155683-00-4 10mg $102 2024-03-01 Buy
ApexBio Technology N2245 NotoginsenosideFt1 155683-00-4 20mg $400 2021-12-16 Buy
Product number Packaging Price Buy
24976 1mg $26 Buy
24976 500μg $32 Buy
24976 5mg $83 Buy
24976 10mg $102 Buy
N2245 20mg $400 Buy

Notoginsenoside Ft1 Chemical Properties,Uses,Production

Description

Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities. It induces proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) via nuclear translocation of hypoxia-inducible factor-1α (HIF-1α) and activation of the PI3K/AKT and Raf/MEK/ERK signaling pathways in a manner dependent on mammalian target of rapamycin (mTOR). Notoginsenoside Ft1 (45 μM) induces cell cycle arrest at the S and G2/M phases and promotes apoptosis of SH-SY5Y cells. It increases cGMP levels and induces relaxation of isolated precontracted rat mesenteric arteries, effects that are reversed by the nitric oxide synthase inhibitor L-NAME and ODQ , an inhibitor of soluble guanylyl cyclase. In vivo, notoginsenoside Ft1 (0.25, 2.5, and 25 mg/kg) promotes angiogenesis and decreases wound diameter in a mouse model of punched-hole ear injury. Notoginsenoside Ft1 (1.25 mg/kg) decreases tail bleeding time and increases thrombus weight in a rat tail bleeding assay. Topical administration of notoginsenoside Ft1 increases mRNA expression of the collagen expression, fibroblast proliferation, and scar formation genes COL1A1, COL3A1, TGF-β1, TGF-β3, and fibronectin, promotes neovascularization, reduces monocyte infiltration, and shortens wound closure time in a db/db mouse model of diabetic foot ulcers.

Uses

Notoginsenoside Ft1 is a saponin isolated from Panax notoginseng; stimulator of angiogenesis. IC50 value: Target: angiogenesis stimulator in vitro: Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways [1]. Among the saponins examined, Ft1 was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel. Ft1 binds to platelet P2Y12 receptors. The increase in intracellular Ca(2+) evoked by Ft1 in HEK293 cells overexpressing P2Y12 receptors could be blocked by ticagrelor [2]. Ft1 caused endothelium-dependent relaxations, which were abolished by l-NAME (inhibitor of nitric oxide synthases) and ODQ (inhibitor of soluble guanylyl cyclase). Ft1 increased the cGMP level in rat mesenteric arteries. GR and ER were present in the endothelial layer and their antagonism by RU486 and PHTPP, respectively, inhibited Ft1-induced endothelium-dependent relaxations and phosphorylations of eNOS, Akt and ERK1/2 [3]. Ft1 showed the best inhibitory effect on cell proliferation of SH-SY5Y cells with IC50 of 45μM. Ft1 not only arrested the cell cycle at S, G2/M stages, but also promoted cell apoptosis. Ft1 up-regulated the protein expressions of cleaved caspase 3, phospho-p53, p21, and cyclin B1, but down-regulated that of Bcl-2. Moreover, Ft1 enhanced the phosphorylation of ERK1/2, JNK and p38 MAPK [4]. in vivo: Ft1 promotes the formation of blood vessels in Matrigel plug and wound healing in mice [1].

References

[1] Shen K, et al. Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways. Biochem Pharmacol. 2012 Sep 15;84(6):784-92. DOI:10.1016/j.bcp.2012.05.024
[2] Gao B, et al. Platelet P2Y?? receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng. Br J Pharmacol. 2014 Jan;171(1):214-23. DOI:10.1111/bph.12435
[3] Shen K, et al. Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries. Biochem Pharmacol. 2014 Mar 1;88(1):66-74. DOI:10.1016/j.bcp.2014.01.007
[4] Gao B, et al. p38 MAPK and ERK1/2 pathways are involved in the pro-apoptotic effect of notoginsenoside Ft1 on human neuroblastoma SH-SY5Y cells. Life Sci. 2014 Jul 17;108(2):63-70. DOI:10.1016/j.lfs.2014.05.010

Notoginsenoside Ft1 Preparation Products And Raw materials

Raw materials

Preparation Products

Notoginsenoside Ft1 Suppliers

Global( 130)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531157085 abby@chuanghaibio.com China 8808 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12811 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Chengdu Greenpure Biopharma CO.,Ltd 		18283602253; +8618283602253 jancyzheng@gcgreenpure.com China 953 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29859 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 3772 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 sales@dolonchem.com CHINA 2972 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Shanghai Standard Technology Co., Ltd. 		18502101150 ft-sales@nature-standard.com CHINA 1923 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
Chengdu Greenpure Biopharma CO.,Ltd 		58
career henan chemical co 		58
Chengdu GLP biotechnology Co Ltd 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Standard Technology Co., Ltd. 		58

View Lastest Price from Notoginsenoside Ft1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Notoginsenoside Ft1 pictures 2025-04-23 Notoginsenoside Ft1
155683-00-4
 US $10.00 / KG 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd
Notoginsenoside Ft1 pictures 2025-03-21 Notoginsenoside Ft1
155683-00-4
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
Notoginsenoside Ft1 pictures 2024-11-19 Notoginsenoside Ft1
155683-00-4
 US $30.00-81.00 / mg 99.75% 10g TargetMol Chemicals Inc.

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Notoginsenoside Ft1 (3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl O-beta-D-xylopyranosyl-(1- 2)-O-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside product/153944 β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)- (2S,3R,4S,5R)-2-[(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Notoginsenoside Ft1, 10 mM in DMSO 155683-00-4 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract