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(+/-)-BLEBBISTATIN

(+/-)-BLEBBISTATIN
(+/-)-BLEBBISTATIN structure
CAS No.
674289-55-5
Chemical Name:
(+/-)-BLEBBISTATIN
Synonyms
(±)Bebbistatin;(+/-)-BLEBBISTATIN;(R)-(+)-BLEBBISTATIN;3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one;(+/-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE;1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one;(+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-β]-7-methylquinolin-4-one;4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-Methyl-1-phenyl-;(3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one;(3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
CBNumber:
CB0787697
Molecular Formula:
C18H16N2O2
Formula Weight:
292.33184
MOL File:
674289-55-5.mol

(+/-)-BLEBBISTATIN Properties

Melting point:
210-212°C
Boiling point:
507.3±60.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
−20°C
pka
11.15±0.20(Predicted)
form 
Bright yellow solid.
CAS DataBase Reference
674289-55-5
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36/37

(+/-)-BLEBBISTATIN price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 203390 (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem 674289-55-5 5mg $206 2019-12-02 Buy
Cayman Chemical 13186 (±)-Blebbistatin ≥98% 674289-55-5 5mg $69 2020-06-24 Buy
Cayman Chemical 13186 (±)-Blebbistatin ≥98% 674289-55-5 10mg $155 2020-06-24 Buy
Cayman Chemical 13186 (±)-Blebbistatin ≥98% 674289-55-5 25mg $276 2020-06-24 Buy
Cayman Chemical 13186 (±)-Blebbistatin ≥98% 674289-55-5 50mg $518 2020-06-24 Buy

(+/-)-BLEBBISTATIN Chemical Properties,Uses,Production

Chemical Properties

Bright Yellow Solid

Uses

Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

Uses

(±)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light, which may be particularly important in fluorescent cell imaging applications. Purified enantiomers of Blebbistatin are also available from Cayman ((?)-Blebbistatin - ).

Definition

ChEBI: A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase ac ivity of non-muscle myosin II.

Biological Activity

Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

(+/-)-BLEBBISTATIN Preparation Products And Raw materials

Raw materials

Preparation Products


(+/-)-BLEBBISTATIN Suppliers

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