Nalmefene hydrochloride
- CAS No.
- 58895-64-0
- Chemical Name:
- Nalmefene hydrochloride
- Synonyms
- Revex;NALMEFENE HCL;Unii-K7K69qc05x;Nalmefene Impurity 2;nalmefene hydrochloride;Nalmefene Hydrochloride IMP;Nalmefene Hydrochloride Impurity;(5a)-17-(CyclopropylMethyl)-6-Methylene-4,5-epoxyMorphinan-3,14-diol;(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diolhydrochloride;17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
- CBNumber:
- CB0855103
- Molecular Formula:
- C21H26ClNO3
- Molecular Weight:
- 375.89
- MDL Number:
- MFCD27937056
- MOL File:
- 58895-64-0.mol
| Melting point | 180-185° |
|---|---|
| storage temp. | Desiccate at RT |
| solubility | Soluble in Water (up to 25 mg/ml). |
| form | solid |
| pka | 7.63(at 25℃) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 58895-64-0 |
| FDA UNII | K7K69QC05X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H312-H317-H302-H332-H334 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P261-P285-P304+P341-P342+P311-P501 |
Nalmefene hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4085 | Nalmefenehydrochloride ≥99%(HPLC) | 58895-64-0 | 50 | $118 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009358 | NALMEFENE HYDROCHLORIDE 95.00% | 58895-64-0 | 1MG | $400.43 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009358 | NALMEFENE HYDROCHLORIDE 95.00% | 58895-64-0 | 5MG | $402.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009358 | NALMEFENE HYDROCHLORIDE 95.00% | 58895-64-0 | 10MG | $404.35 | 2021-12-16 | Buy |
| Crysdot | CD31001381 | NalmefeneHydrochloride 98% | 58895-64-0 | 250mg | $160 | 2021-12-16 | Buy |
Nalmefene hydrochloride Chemical Properties,Uses,Production
Description
Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal following surgery, and in the reversal of opioid overdoses and epidurally administered narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and subjective effects of opioids. It has a higher potency, a longer duration of action, and superior bioavailability than the structurally related naltrexone. Nalmefene has a wide spectrum of biological activity and is in clinical trials for the treatment of interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like effects and has no apparent abuse potential.
Originator
IVAX (U.S.A.)
Uses
Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist
brand name
Revex
storage
Desiccate at RT
References
1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624 2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588 3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154 4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence – a critical review; Curr. Drug Abuse Rev., 1 280
Nalmefene hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 | |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 6003 | 58 |
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | ada@sh-teruiop.com | China | 893 | 58 |
View Lastest Price from Nalmefene hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-11-16 | Nalmefene hydrochloride
58895-64-0
|
US $35.00 / KG | 1KG | 99% | 20 Tons | Longyan Tianhua Biological Technology Co., Ltd | |
 |
2019-07-06 | Nalmefene hydrochloride
58895-64-0
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Nalmefene hydrochloride
58895-64-0
- US $35.00 / KG
- 99%
- Longyan Tianhua Biological Technology Co., Ltd
-
- Nalmefene hydrochloride
58895-64-0
- US $2.00 / kg
- 99%
- Career Henan Chemical Co