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Lipoic acid

B vitamins Uses
Lipoic acid
Lipoic acid structure
Chemical Name:
Lipoic acid
Biletan;Liposan;Thioctic;Lipothion;Thioctsan;Tioctacid;Heparlipon;Protogen A;Thioctacid;Tioctidasi
Molecular Formula:
Formula Weight:
MOL File:

Lipoic acid Properties

Melting point:
48-52 °C(lit.)
Boiling point:
315.2°C (rough estimate)
1.2888 (rough estimate)
refractive index 
1.5200 (estimate)
Flash point:
>230 °F
Very slightly soluble in water, very soluble in dimethylformamide, freely soluble in methanol.
CAS DataBase Reference
62-46-4(CAS DataBase Reference)
NIST Chemistry Reference
Lipoic acid(62-46-4)
  • Risk and Safety Statements
WGK Germany  3

Lipoic acid Chemical Properties,Uses,Production

B vitamins

Lipoic acid is a class of compounds belonging to the B class vitamins and is the growth factor of yeast and some kinds of microorganisms. It can play the role of coenzyme role in a multi-enzyme system that is responsible for catalyzing the acyl transfer effect in the reaction of oxidative decarboxylation of pyruvate into acetate and oxidative decarboxylation reaction of α-ketoglutarate into succinic acid. Its chemical name is 5-[3-(1,2-dithiol hetero-cycle)] pentanoic acid. The appearance is pale yellow crystals with the molecular weight being 206.33. DL-body: the melting point is 60~61 ℃. L-body (natural products): the melting point is 45~47.5 ℃. Optical rotation [α] D23 + 113 ℃. D-body (natural products): the melting point is 46~48 ℃. Optical rotation [α] D23 + 104 ℃. It is soluble in organic solvents but insoluble in water. It can be used for the prevention and treatment of acute hepatitis, liver cirrhosis, hepatic coma, fatty liver and other diseases. The natural material is found in the liver, kidneys and heart. Synthetic products is obtained through condensation of ethylene and adipic acid mono-ester chloride in the presence of aluminum chloride into chloropropionyl pivaloyl ester, which further has condensation reaction with sulfuric acid, then go through reduction with sodium borohydride and sodium hydroxide hydrolysis, and finally have reaction with thiourea to obtain it.
6,8-lipoic acids can be dissolved in water and can often be presented together with vitamin B1. There are two forms including oxidized and reduced (6,8-dimercapto octanoic acid) types. Inside the body of organisms, some hydrogen group and acyl group can be accepted or transferred through the conversion of these two forms. It can be taken as the coenzyme of the α-keto acid oxidation decarboxylase and hydroxyethyl enzyme and play the role of acyl and hydrogen group transfer during metabolic pathways. Since the human body can synthesize it, no cases of deficiency have been reported before. However, it is indispensable factors for the growth and development of some microorganisms and protozoa. It is rich in liver and yeast.
The above information is edited by the chemicalbook of Dai Xiongfeng.


It is a kind of B vitamins and can be used for the treatment of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes, etc.
It can be used as a kind of antioxidants

Chemical Properties

Thioctic acid, 6,8-dithiooctanoic acid


hydrogen-transferring cofactor, potentiating anti-oxidant


ChEBI: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.


lipoic acid: A vitamin of the vitaminB complex. It is one of thecoenzymes involved in the decarboxylationof pyruvate by the enzymepyruvate dehydrogenase. Goodsources of lipoic acid include liverand yeast.

Lipoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Lipoic acid Suppliers

Global( 296)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21821 58
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 CHINA 115 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22626 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 30045 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28234 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 10171 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6371 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5921 58

View Lastest Price from Lipoic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-30 Lipoic acid
US $1.00-1.00 / Kg/Bag 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2019-12-03 Lipoic acid
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2018-07-26 Lipoic acid
US $15.00 / KG 1KG 99% 1000KG career henan chemical co

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