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オキサリプラチン

オキサリプラチン 化学構造式
61825-94-3
CAS番号.
61825-94-3
化学名:
オキサリプラチン
别名:
オキサリプラチン;(trans-1,2-シクロヘキサンジアミン)オキサラト白金(II);オキサリプラチン (JAN)
英語化学名:
Oxaliplatin
英語别名:
ι-OHP;1-ohp;Elplat;Lipoxal;Dacplat;P-54780;Eloxatin;Elocatin;RP-54780;NSC-266046
CBNumber:
CB1217931
化学式:
C8H14N2O4Pt
分子量:
397.29
MOL File:
61825-94-3.mol

オキサリプラチン 物理性質

比旋光度 :
+74.5-78.0 (D/20)(c=0.5,H2O)
貯蔵温度 :
Store at +4°C
溶解性:
Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
外見 :
solid
水溶解度 :
Soluble in water with heating and/or sonication
Merck :
14,6912
安定性::
Stable. Store cool. Incompatible with oxidizing agents.
InChIKey:
ZROHGHOFXNOHSO-BNTLRKBRSA-L
CAS データベース:
61825-94-3
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,Xi
Rフレーズ  36/37/38-40-42/43
Sフレーズ  26-36
RIDADR  2811
WGK Germany  3
RTECS 番号 TP2275850
国連危険物分類  6.1(a)
容器等級  II
HSコード  28439000
安衛法 変異原性物質
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H334 吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ 感作性、呼吸器 1 危険 P261, P285, P304+P341, P342+P311,P501
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P284 呼吸用保護具を着用すること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

オキサリプラチン 価格 もっと(12)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTO9201 オキサリプラチン
Oxaliplatin
61825-94-3 25mg ¥13800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTO9201 オキサリプラチン
Oxaliplatin
61825-94-3 5mg ¥6400 2018-12-26 購入
東京化成工業 O0372 オキサリプラチン
Oxaliplatin
61825-94-3 100mg ¥20500 2018-12-04 購入
Sigma-Aldrich Japan O9512 オキサリプラチン solid
Oxaliplatin solid
61825-94-3 5mg ¥23800 2018-12-25 購入
Sigma-Aldrich Japan 1481204 オキサリプラチン United States Pharmacopeia (USP) Reference Standard
Oxaliplatin United States Pharmacopeia (USP) Reference Standard
61825-94-3 125mg ¥360400 2018-12-25 購入

オキサリプラチン 化学特性,用途語,生産方法

外観

白色〜わずかにうすい褐色, 結晶性粉末〜粉末

溶解性

水に溶ける。

用途

DNA 鎖内及び鎖間の白金 -DNA 架橋を形成し、DNA の複製及び転写阻 害作用を示します。

用途

がん研究用試薬

効能

抗悪性腫瘍薬, 細胞増殖阻害薬

商品名

エルプラット (ヤクルト本社)

説明

Eloxatin was launched in France for second-line treatment of metastatic colorectal cancer. Oxaliplatin is a second generation platinum drug prepared in three steps from either k2tCl4 or K2Ptl4. It has an antitumor spectrum similar to cisplatin, however, it is more effective against L1210 leukemia and cisplatin resistant L1210. It is also effective against B16 melanoma but has a dose limiting toxicity of peripheral sensory neuropathy that is reversible upon cessation of the drug. The (R,R)- enantiomer has greater activity than the (S,S)-isomer but this is tumor line dependent, e.g., there was no difference found for P-388 or Sarcoma 180. Clinical drug administration based on circadium timing showed it was better tolerated when given 16 h after the onset of light. Oxaliplatin binds to guanineN7 and can lead to bidentate chelation that results in the bending of DNA. This feature is recognized by high mobility group proteins (HMG) which impedes repair reactions and stops replication and transcription.

化学的特性

White Crystalline Solid

Originator

Bebiopharm (Switzerland)

使用

Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.

使用

vasodilator

使用

A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines

使用

Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.

使用

A antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA

brand name

Eloxatin (Sanofi Aventis).

一般的な説明

Oxaliplatin is available in 50- and 100-mg vials for IV administrationin the treatment of ovarian cancer, metastaticcolorectal cancer, and early stage colon cancer in combinationwith 5-fluorouracil/leucovorin. The activation of theagent occurs in low-chloride environments to give theaquated species, which subsequently reacts with DNA in amanner similar to cisplatin. The mechanisms of resistance aresimilar for the two agents; however, oxaliplatin is not recognizedby MMR enzymes and does not show cross-resistancewith cisplatin. The agent is widely distributed, highly proteinbound (85%–88%), and irreversibly binds to erythrocytes.Numerous metabolites have been identified many of whichare produced as a result of nonenzymatic processes and includechloro-, dichloro-, monoaquo-, and diaquo-species.The parent and metabolites are eliminated primarily in theurine with a long terminal elimination half-life of 240 hours.Neurotoxicity is dose limiting and normally presents as peripheralneuropathy, which may be exacerbated by exposureto low temperatures. The neurotoxicity is normally reversiblein contrast to that seen with cisplatin, which may be irreversible.Other adverse effects include nausea, vomiting, diarrhea,myelosuppression, and hypersensitivity reactions.Ototoxicity and renal toxicity occur only rarely in contrast tocisplatin.

生物活性

Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ) and shows antitumor activity in cell lines with acquired cisplatin resistance.

オキサリプラチン 上流と下流の製品情報

原材料

準備製品


オキサリプラチン 生産企業

Global( 339)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Jiangsu Yew Pharmaceutical Co., Ltd.
+86-510-66865338 +86-189-2133-5032 jiangwenjun@hongdou.com
+86-510-66865972 junwenjiang@live.cn , jiangwenjun@hongdou.com CHINA 29 60
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 306 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21676 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1017 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58

61825-94-3(オキサリプラチン)キーワード:


  • 61825-94-3
  • oxalatoplatinum
  • oxaliplatino
  • Oxaliplatin99%
  • OxaliplatinEp5
  • (1R-trans)-1,2-Cyclohexanediamine, platinum complex
  • Dacplat
  • Eloxatin
  • Elplat
  • Lipoxal
  • Platinum, [(1R,2R)-1,2-cyclohexanediamine-kN1,kN2][ethanedioato(2-)-kO1,kO2]-, (SP-4-2)-
  • [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine- N,Nˊ)[ethanedioato(2-)-O,Oˊ]platinum
  • OXALIPIATIN
  • Cis-[(1R,2R)-1,2-cyclothexanediammine-N,N`][oxalato(2-)-O,O`]platinum
  • SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE- N,N)[ETHANEDIOATO(2-)-O,OPT
  • Elocatin
  • NSC-266046
  • P-54780
  • xalatoplatinum
  • ι-OHP
  • [SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM
  • OXALIPLATIN
  • trans-l-diaminocyclohexane oxalatoplatinum
  • (1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr
  • 1-ohp
  • oxalato(1r,2r-cyclohexanediammine)platinum(ii)
  • oxalatoplatin
  • [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N,)[ethanedioato(2-)-O,O’Jplatinum
  • NSC-266046:Elocatin
  • RP-54780
  • [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine- N,N
  • オキサリプラチン
  • (trans-1,2-シクロヘキサンジアミン)オキサラト白金(II)
  • オキサリプラチン (JAN)
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