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Sasapyrine

Sasapyrine
Sasapyrine structure
CAS No.
552-94-3
Chemical Name:
Sasapyrine
Synonyms
Salina;diagen;Salysal;Disalyl;Nobacid;Salical;salflex;Saloxium;salgesic;salsitab
CBNumber:
CB1240724
Molecular Formula:
C14H10O5
Formula Weight:
258.23
MOL File:
552-94-3.mol

Sasapyrine Properties

Melting point:
139-151 °C
Boiling point:
361.48°C (rough estimate)
Density 
1.3326 (rough estimate)
refractive index 
1.4825 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: ≥15mg/mL
form 
Crystalline Powder
pka
pKa 3.5 (Uncertain);9.8 (Uncertain)
color 
white to tan
Water Solubility 
HYDROLYSIS
Sensitive 
Moisture Sensitive
Merck 
14,8339
CAS DataBase Reference
552-94-3
FDA 21 CFR
310.545
EWG's Food Scores
1
FDA UNII
V9MO595C9I
NCI Drug Dictionary
Disalcid
ATC code
N02BA06
NIST Chemistry Reference
2-Carboxyphenyl salicylate(552-94-3)
EPA Substance Registry System
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester (552-94-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P301+P312+P330-P273-P391
Hazard Codes  Xi,N,Xn
Risk Statements  36/37/38-50-22
Safety Statements  37/39-26-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  DH2080000
TSCA  Yes
HS Code  29182300
NFPA 704
1
2 0

Sasapyrine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1941 Salsalate (Aspirin Impurity E) Pharmaceutical Secondary Standard; Certified Reference Material 552-94-3 200mg $256 2021-12-16 Buy
Sigma-Aldrich 1609807 Salsalate United States Pharmacopeia (USP) Reference Standard 552-94-3 150mg $366 2021-12-16 Buy
TCI Chemical S0129 2-Carboxyphenyl Salicylate >98.0%(HPLC)(T) 552-94-3 25g $23 2021-12-16 Buy
TCI Chemical S0129 2-Carboxyphenyl Salicylate >98.0%(HPLC)(T) 552-94-3 100g $50 2021-12-16 Buy
Alfa Aesar B22444 Salicylsalicylic acid, 98% 552-94-3 25g $53.7 2021-12-16 Buy

Sasapyrine Chemical Properties,Uses,Production

Description

Salsalate, or salicylsalicylic acid, (pKa 3.5 [COOH], 9.8 [AR-OH]) is a dimer of salicylic acid. It is insoluble in gastric juice but is soluble in the small intestine, where it is partially hydrolyzed to two molecules of salicylic acid and absorbed. On a molar basis, it produces 15% less salicylic acid than aspirin. It does not cause GI blood loss and can be given to aspirin-sensitive patients. Salsalate is available as capsules and tablets.

Chemical Properties

white crystalline powder

Uses

Nonacetylated aspirin analog. Analgesic, anti-inflammatory.

Uses

Nonacetylated (e.g., sodium salicylate) and acetylated (aspirin) forms of salicylate are widely used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain. Sasapyrine is a dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.

Uses

Salicylsalicylic acid is used in organic synthesis and functions as a plant hormone, as a key ingredient in topical anti-acne products.

Definition

ChEBI: A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthrit s and also shows activity against type II diabetes.

brand name

Disalcid (3M Pharmaceuticals).

General Description

Salsalate, salicylsalicylic acid (Amigesic, Disalcid,Salflex), is the ester formed between two salicylic acidmolecules. It is rapidly hydrolyzed to salicylic acid followingits absorption. It reportedly causes less gastric irritationthan aspirin, because it is relatively insoluble inthe stomach and is not absorbed until it reaches the smallintestine.

Biochem/physiol Actions

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

Sasapyrine Preparation Products And Raw materials

Raw materials

Preparation Products


Sasapyrine Suppliers

Global( 206)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

View Lastest Price from Sasapyrine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Sasapyrine
552-94-3
US $1.90 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-08-12 Sasapyrine
552-94-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-20 Sasapyrine
552-94-3
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

Sasapyrine Spectrum


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