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3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide

3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide structure

CAS No.: 1164153-22-3

Chemical Name:: 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide

Synonyms: SR-3576;JNK3 Inhibitor XII;SR-3576 >=98% (HPLC);JNK3 Inhibitor XII, SR-3576;JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem;3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide;3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide;3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide;Benzamide, 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-

CBNumber:: CB12750449

Molecular Formula:: C27H27N5O5

Molecular Weight:: 501.53

MDL Number:: MFCD18632556

MOL File:: 1164153-22-3.mol

Last updated:2023-06-30 15:45:59

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3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Properties

Boiling point	557.7±50.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥20mg/mL
form	powder
pka	11.51±0.70(Predicted)
color	light brown to brown
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	2933399990

3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	420143	JNK3 Inhibitor XII, SR-3576	1164153-22-3	5mg	$159	2024-03-01	Buy
Tocris	5044	SR3576 ≥97%(HPLC)	1164153-22-3	10	$183	2021-12-16	Buy
Tocris	5044	SR3576 ≥97%(HPLC)	1164153-22-3	50	$753	2021-12-16	Buy
Usbiological	256745	SR 3576	1164153-22-3	10mg	$466	2021-12-16	Buy
TRC	S684518	SR3576	1164153-22-3	10mg	$195	2021-12-16	Buy

Product number	Packaging	Price	Buy
420143	5mg	$159	Buy
5044	10	$183	Buy
5044	50	$753	Buy
256745	10mg	$466	Buy
S684518	10mg	$195	Buy

3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Chemical Properties,Uses,Production

Description

SR-3576 (1164153-22-3) is a potent and selective JNK3 inhibitor. IC50?= 7nM and >2800-fold selective over p38.1?Cell permeable.

Uses

SR 3576 is a JNK-3 selective inhibitor.

General Description

A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC₅₀ = 7 nM), inhibiting JNK1 only at much higher concentrations (IC₅₀ = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 μM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC₅₀ = 1.3 μM).

Biochem/physiol Actions

SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1

storage

Store at -20°C

References

1) Kamenecka?et al. (2009),?Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38; J. Biol. Chem.,?284?12853

3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Suppliers

Global( 40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Sigma-Aldrich	80
Shanghai EFE Biological Technology Co., Ltd.	58
BOC Sciences	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Energy Chemical	58
MedBioPharmaceutical Technology Inc	58
Changzhou Furuisi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58

1164153-22-3(3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide)Related Search:

CHK2 INHIBITOR II TYRPHOSTIN AG 1296 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- SU 4312

3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide SR-3576 JNK3 Inhibitor XII, SR-3576 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem 3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide JNK3 Inhibitor XII SR-3576 >=98% (HPLC) Benzamide, 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)- 1164153-22-3