PD-L1 inhibitor 1
- CAS No.
- 1675203-84-5
- Chemical Name:
- PD-L1 inhibitor 1
- Synonyms
- BMS-202;CS-2416;PD1 inhibitor 2;PD 1 inhibitor 2;PD-1 inhibitor 2;PD-L1 inhibitor 2;PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;PD-1/PD-L1 inhibitor 2(BMS-202);BMS202 (PD-1/PD-L1 inhibitor 2)
- CBNumber:
- CB13043328
- Molecular Formula:
- C25H29N3O3
- Molecular Weight:
- 419.52
- MDL Number:
- MFCD29905455
- MOL File:
- 1675203-84-5.mol
Boiling point | 611.4±55.0 °C(Predicted) |
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Density | 1.133±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) |
pka | 16.06±0.46(Predicted) |
form | solid |
color | White |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
FDA UNII | KDA2HUE7KP |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
NFPA 704 |
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PD-L1 inhibitor 1 price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 5mg | $172 | 2024-03-01 | Buy |
Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 10mg | $321 | 2024-03-01 | Buy |
Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 25mg | $576 | 2024-03-01 | Buy |
TRC | B695175 | BMS-202 | 1675203-84-5 | 10mg | $310 | 2021-12-16 | Buy |
PD-L1 inhibitor 1 Chemical Properties,Uses,Production
Description
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM.
Uses
BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.
References
1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323 2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857
PD-L1 inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
View Lastest Price from PD-L1 inhibitor 1 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-10 | PD-L1 inhibitor 1
1675203-84-5
|
US $5.50 / KG | 1KG | 98%min | 1kg,10kg,100kg | Career Henan Chemical Co |
- PD-L1 inhibitor 1
1675203-84-5
- US $5.50 / KG
- 98%min
- Career Henan Chemical Co