DOFETILIDE-D4
- CAS No.
- 1189700-56-8
- Chemical Name:
- DOFETILIDE-D4
- Synonyms
- Tikosyn-d;Tikosyn-d4;UK 68789 D4;UK-68798-d4;DOFETILIDE-D4;N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide-d4;N-[4-(2-{[2-(4-methanesulfonamidophenoxy)(1,1,2,2-2H?)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide;Dofetilide D4Q: What is Dofetilide D4 Q: What is the CAS Number of Dofetilide D4 Q: What is the storage condition of Dofetilide D4 Q: What are the applications of Dofetilide D4
- CBNumber:
- CB1648928
- Molecular Formula:
- C19H27N3O5S2
- Molecular Weight:
- 441.56478
- MDL Number:
- MFCD09840517
- MOL File:
- 1189700-56-8.mol
Melting point | 130-1350C |
---|---|
storage temp. | -20°C Freezer |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
color | White |
CAS DataBase Reference | 1189700-56-8 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H302-H319-H360 | |||||||||
Precautionary statements | P201-P202-P264-P270-P280-P301+P312-P330-P305+P351+P338-P308+P313-P337+P313-P405-P501 | |||||||||
NFPA 704 |
|
DOFETILIDE-D4 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 26451 | Dofetilide-d4 | 1189700-56-8 | 500μg | $153 | 2024-03-01 | Buy |
Cayman Chemical | 26451 | Dofetilide-d4 | 1189700-56-8 | 1mg | $290 | 2024-03-01 | Buy |
Usbiological | D8079-25C | Dofetilide-d4 | 1189700-56-8 | 1mg | $460 | 2021-12-16 | Buy |
TRC | D525702 | Dofetilide-d4 | 1189700-56-8 | 10mg | $1455 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | D3782 | Dofetilide-d4 98% | 1189700-56-8 | 1mg | $950 | 2021-12-16 | Buy |
DOFETILIDE-D4 Chemical Properties,Uses,Production
Description
Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg. Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.
Chemical Properties
White Crystalline Solid
Uses
Potassium channel blocker.
Uses
Dofetilide-d4 is intended for use as an internal standard for the quantification of Dofitilide by GC- or LC-mass spectrometry.
DOFETILIDE-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 2765 | 58 |
Clearsynth Canada Inc. | +1.415.685.4395 | enquiry@clearsynth.com | Canada | 912 | 58 |
Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9592 | 60 |
Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2301 | 58 |
Shanghai ring qi biological technology co., LTD | 13524106587 | sales@hq-chem.com | China | 225 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Wuxi Minglu Medicine technology Co.,Ltd. | 0510-88726693 | 3204601684@qq.com | China | 2215 | 58 |