2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid
- CAS No.
- 1186050-58-7
- Chemical Name:
- 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid
- Synonyms
- 6-(2H-1,2,3-Triazole-2-yl)-fluorobenzoicacid;2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid;Benzoic acid, 2-fluoro-6-(2H-1,2,3-triazol-2-yl)-
- CBNumber:
- CB22693167
- Molecular Formula:
- C9H6FN3O2
- Molecular Weight:
- 207.16
- MDL Number:
- MFCD23135320
- MOL File:
- 1186050-58-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| REACH Registrations | Active |
|---|
2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 094503 | 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid | 1186050-58-7 | 250.00mg | $742 | 2026-05-18 | Buy |
| Matrix Scientific | 094503 | 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid | 1186050-58-7 | 1.00g | $1647 | 2026-05-18 | Buy |
| aablocks | AA0075QR | Benzoic acid, 2-fluoro-6-(2H-1,2,3-triazol-2-yl)- 95% | 1186050-58-7 | 1g | $52 | 2026-05-28 | Buy |
| aablocks | AA0075QR | Benzoic acid, 2-fluoro-6-(2H-1,2,3-triazol-2-yl)- 95% | 1186050-58-7 | 5g | $163 | 2026-05-28 | Buy |
| ACHEMBLOCK | U131735 | 2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid 95% | 1186050-58-7 | 5G | $180 | 2026-05-27 | Buy |
2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid Chemical Properties, Uses, Production
Synthesis
111771-08-5
288-36-8
1186050-58-7
Method B: Synthesis of 2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid. In a 2L three-necked round-bottomed flask equipped with an overhead mechanical stirrer, a thermocouple probe, a heating jacket, a reflux condenser, and a nitrogen inlet, 2-fluoro-6-iodobenzoic acid (127.6 g, 480 mmol), copper iodide (4.57 g, 24 mmol), and Cs2CO3 (312.6 g, 959 mmol) were added in sequence. To the solid mixture was added dioxane (640 mL) followed by water (2.6 mL, 144 mmol), 1H-1,2,3-triazole (55.6 mL, 959 mmol) and trans-1,2-dimethylcyclohexane-1,2-diamine (15.1 mL, 96 mmol). The reaction mixture was gradually warmed up to 60°C for 30 minutes, then warmed up to 83°C for 30 minutes and finally warmed up to 100°C for 3 hours of reaction. After completion of the reaction, the mixture was cooled and 1 L of methyl tert-butyl ether (MTBE) and 1 L of water were added. After vigorous stirring, the organic and aqueous layers were separated. The aqueous layer was acidified with concentrated hydrochloric acid (148 mL) to pH 1.72. The acidified aqueous layer was extracted twice with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give a dark colored oil. The oil was dissolved in ethyl acetate (450 mL), stirred overnight and filtered to remove the precipitate. Concentration of the mother liquor gave a brown solid product (106.21 g, 75 wt%, quantitative HPLC showed 79.7 g, 80% yield).1H NMR (400 MHz, DMSO-d6) δ: 8.22-8.13 (broad peak, 2H), 7.84-7.80 (multiple peaks, 1H), 7.74-7.65 (multiple peaks, 1H), 7.50- 7.41 (multiple peaks, 1H).
References
[1] Patent: WO2012/145581, 2012, A1. Location in patent: Page/Page column 50
2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| ChangShu Haitian Fine Chemicals Co.,Ltd | 13913622609 | 974295387@qq.com | China | 192 | 61 |
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View Latest Price from 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-19 | 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid
1186050-58-7
|
1kg | 98% | 1000kg | Shanghai Joiny Pharmaceutical Co.,LTD |
-
- 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid
1186050-58-7
- $0.00
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
