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LEVOCABASTINE

LEVOCABASTINE structure

CAS No.: 79516-68-0

Chemical Name:: LEVOCABASTINE

Synonyms: Bilina;ALKN006000;Levocabastin;LEVOCABASTINE;Levocabastina;Levocabastinum;Unii-H68bp06S81;Levocabastinum [latin];Levocabastina [spanish];Levocabastine [inn:ban]

CBNumber:: CB2307787

Molecular Formula:: C26H29FN2O2

Molecular Weight:: 420.52

MDL Number:: MFCD00672639

MOL File:: 79516-68-0.mol

Last updated:2023-05-04 17:34:42

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LEVOCABASTINE Properties

Boiling point	589.9±50.0 °C(Predicted)
Density	1.23
pka	3.57±0.40(Predicted)
FDA UNII	H68BP06S81
ATC code	R01AC02,S01GX02

LEVOCABASTINE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0006774	LEVOCABASTINE 95.00%	79516-68-0	5MG	$498.26	2021-12-16	Buy
AHH	MT-53192	Levocabastine 98%	79516-68-0	0.5g	$910	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0006774	5MG	$498.26	Buy
MT-53192	0.5g	$910	Buy

LEVOCABASTINE Chemical Properties,Uses,Production

Originator

Livostin,Janssen-Cilag,Belgium

Uses

Anti histaminic.

Definition

ChEBI: Levocabastine is a member of piperidines.

Manufacturing Process

4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)

brand name

Livostin (Novartis).

Therapeutic Function

Antihistaminic

LEVOCABASTINE Preparation Products And Raw materials

Raw materials

Ethyl acrylate 4-Fluorophenylacetonitrile Sodium Methoxide

Preparation Products

LEVOCABASTINE Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3581	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	7433	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3420	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
TargetMol Chemicals Inc.	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	58
LGM Pharma	70
BOC Sciences	65
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
BOC Sciences	65

View Lastest Price from LEVOCABASTINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-20	Levocabastine 79516-68-0	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd
	2021-06-18	LEVOCABASTINE USP/EP/BP 79516-68-0	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Levocabastine
79516-68-0
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

LEVOCABASTINE USP/EP/BP
79516-68-0
US $1.10 / g
99.9%
Dideu Industries Group Limited

79516-68-0(LEVOCABASTINE)Related Search:

Antazoline Pirenoxine 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 1-(4-FLUOROPHENYL)CYCLOHEXANECARBONITRILE

1-Phenyl-1-cyclohexanecarbonitrile 4-Fluorophenylacetonitrile 4-Phenylcyclohexanamine LEVOCABASTINE LEVOCABASTINE IMPURITY D

4-Piperidinecarboxylicacid,1-(1-methylethyl)-(9CI) 4-Piperidinemethanol,1-(1-methylethyl)-(9CI) (αS)-α-Isopropylbenzeneacetic acid PETHIDINIC ACID 5-Piperidinovaleronitrile

Cabastine 4-phenyl-1-(4-phenylbutyl)piperidine

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Levocabastine & Levocabastine Hydrochloride (3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid (3S,4R)-1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-Methyl-4-phenylpiperidine-4-carboxylic acid LEVOCABASTINE 4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, [3S-[1(cis),3a,4b]]- 4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, (3S,4R)- (9CI) (3S)-1-[4α-Cyano-4-(4-fluorophenyl)cyclohexan-1α-yl]-3β-methyl-4-phenylpiperidine-4α-carboxylic acid (3S)-1-[4α-Cyano-4β-(4-fluorophenyl)cyclohexan-1α-yl]-3β-methyl-4β-phenyl-4α-piperidinecarboxylic acid 4-Piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3alpha,4beta))- 79547-78-7 (Hydrochloride) Levocabastina Levocabastina [spanish] Levocabastine [inn:ban] Levocabastinum Levocabastinum [latin] Unii-H68bp06S81 Levocabastin (3S,4R)-3-methyl-4-phenyl-1-[(1s,4s)-4-cyano-4-(4-fluorophenyl)cyclohexyl]piperidine-4-carboxylic acid 4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, (3S,4R)- LEVOCABASTINE USP/EP/BP Bilina ALKN006000 79516-68-0 C26H29FN2O2