ML 204
- CAS No.
- 2070015-10-8
- Chemical Name:
- ML 204
- Synonyms
- ML204 hydrochloride,ML-204 hydrochloride
- CBNumber:
- CB23373068
- Molecular Formula:
- C15H19ClN2
- Molecular Weight:
- 262.78
- MDL Number:
- MFCD30377212
- MOL File:
- 2070015-10-8.mol
ML 204 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5790 | ML204(hydrochloride) 99.64% | 2070015-10-8 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-5790 | ML204(hydrochloride) 99.64% | 2070015-10-8 | 10mg | $80 | 2021-12-16 | Buy |
| AK Scientific | 3084DH | ML204hydrochloride | 2070015-10-8 | 5mg | $109 | 2021-12-16 | Buy |
| ChemScene | CS-5790 | ML204(hydrochloride) 99.64% | 2070015-10-8 | 50mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-5790 | ML204(hydrochloride) 99.64% | 2070015-10-8 | 100mg | $280 | 2021-12-16 | Buy |
ML 204 Chemical Properties,Uses,Production
Biological Activity
ML204 is a potent and selective inhibitor of TRPC4/TRPC5 channels with 20-fold selectivity over TRPC6, without affecting other TRP channels and voltage-gated sodium, potassium or Ca2+ channels.
in vitro
ML204 inhibits TRPC4β-mediated intracellular Ca 2+ rise with an IC 50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
It blocks TRPC4β activity induced through either G i/o stimulation by μ-opioid, 5HT 1A serotonin, and M 2 muscarinic receptors or G q/11 stimulation by the endogenous M 3 -like muscarinic receptors.
It blocks LPS-induced TRPC5 channel activity.
in vivo
ML204 (1 mg/kg; sc; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.
| Animal Model: | Nonfasted male C57BL/6 (2-3 months) |
| Dosage: | 1 mg/kg |
| Administration: | < td class="col2"> Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)|
| Result: | < td class="col2"> Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
target
| TRPC4
| TRPC5
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9440 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3538 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Shanghai tingchong biology science and technology co., ltd | 18964309092 18964309092 | 2769493375@qq.com | China | 2635 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |