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Irinotecan hydrochloride

Irinotecan hydrochloride
Irinotecan hydrochloride structure
CAS No.
100286-90-6
Chemical Name:
Irinotecan hydrochloride
Synonyms
CTP-11;CPT-II;campto;CPT-11;u10144oe;U 101440E;topotecin;Irinotecan HCI;IRINOTECAN HCL;Camptothecin 11
CBNumber:
CB8122429
Molecular Formula:
C33H39ClN4O6
Formula Weight:
623.14
MOL File:
100286-90-6.mol

Irinotecan hydrochloride Properties

Melting point:
250-256°C (dec.)
Boiling point:
257 °C
refractive index 
67.7 ° (C=1, H2O)
storage temp. 
Refrigerator
solubility 
Soluble in DMSO or DMF at approximately 20mg/ml. Sparingly soluble in aqueous buffers. /n
Water Solubility 
Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck 
5091
CAS DataBase Reference
100286-90-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  DW1060750
HS Code  29399990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.

Irinotecan hydrochloride price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I1406 Irinotecan hydrochloride topoisomerase inhibitor 100286-90-6 50mg $146 2018-11-13 Buy
Sigma-Aldrich I1406 Irinotecan hydrochloride topoisomerase inhibitor 100286-90-6 250mg $523 2018-11-13 Buy
Alfa Aesar J60743 Irinotecan hydrochloride 100286-90-6 250mg $660 2018-11-13 Buy
Alfa Aesar J60743 Irinotecan hydrochloride 100286-90-6 50mg $162 2018-11-13 Buy
Cayman Chemical 14180 Irinotecan (hydrochloride) ≥98% 100286-90-6 25mg $45 2018-11-13 Buy

Irinotecan hydrochloride Chemical Properties,Uses,Production

Description

lrinotecan hydrochloride, a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Although being much less toxic than camptothecin, a significant number of patients in clinical trials exhibited side effects of leukopenia, diarrhea, nauseahromiting, and alopecia. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin's lymphoma.

Chemical Properties

Yellow Crystalline Powder

Originator

Yakult Honsha (Japan)

Uses

antineoplactic;'inhibitor of topoisomerase I

Uses

A DNA topoisomerase inhibitor

Definition

ChEBI: A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancr as after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

brand name

Camptosar (Pharmacia &Upjohn) ;Topotecin.

General Description

Irinotecan is available in 100-mg or 5-mL vials for IV administrationand is used in combination with 5-FU and leucovorinas first-line treatment of metastatic colon cancer.The agent may also be used as a single agent in colorectalcancer as a second-line therapy when 5-FU therapy hasfailed. Additional uses include small cell lung cancer,NSCLC, cervical cancer, esophageal cancer, and gastric cancer Irinotecan is 30% to 60% plasma protein bound, whereasthe active metabolite SN-38 is 95% protein bound. Bindingof SN-38 as the lactone stabilizes the material to ring opening.The elimination of the agent occurs primarily in the bilewith a minor amount of renal elimination. The excretion ofactive metabolites or inactive metabolites such as the glucuronideSN-38G, which may be converted back to SN-38 inthe bile, has been associated with severe diarrhea. Irinotecanand SN-38 have half-lives of 8 and 14 hours, respectively.Irinotecan has two dose-limiting toxicities, myelosuppressionand diarrhea. The diarrhea occurs in two forms, earlyand late. The early form occurs within the first 24 hours afteradministration. It has been associated with inhibition ofacetylcholinesterase, which results in increased gut motility.This early phase is also associated with flushing, abdominalpain, and excessive sweating. Atropine can be used to relievethese symptoms but it is not recommended for prophylacticuse unless there has been a prior episode. The late-phasediarrhea occurs after 24 hours and has been associated withthe presence of active material, particularly SN-38 in the gut,and may last 3 to 10 days. The prolonged nature may lead todehydration and electrolyte imbalances. Loperamide therapyis recommended at the first appearance of a loose stool. If thediarrhea persists, additional agents may be used includingantibiotics that decrease β-glucosidase–producing bacteria inthe gut and prevent the overgrowth of pathogenic bacteria.111Other toxicities include emesis and alopecia.

Biological Activity

Inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types.

Irinotecan hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Irinotecan hydrochloride Suppliers

Global( 273)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19919 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58

View Lastest Price from Irinotecan hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Irinotecan hydrochloride
100286-90-6
US $8.00 / kg 1kg 99% 10tons career henan chemical co
2018-12-24 Irinotecan hydrochloride
100286-90-6
US $2.00 / kg 1kg 99% 100kg career henan chemical co
2018-12-24 Irinotecan hydrochloride
100286-90-6
US $1.00 / kg 1g 99% 100KG career henan chemical co

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