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Nabumetone

Nabumetone
Nabumetone structure
CAS No.
42924-53-8
Chemical Name:
Nabumetone
Synonyms
relifex;RELAFEN;BRL-14777;Nabumeton;brl147777;NABUMETONE;Nabumetone (DMF);Nabumetone (200 mg);NABUMETONE, BP STANDARD;NABUMETONE, EP STANDARD
CBNumber:
CB2386779
Molecular Formula:
C15H16O2
Formula Weight:
228.29
MOL File:
42924-53-8.mol

Nabumetone Properties

Melting point:
80-810C
Boiling point:
330.1°C (rough estimate)
Density 
1.0657 (rough estimate)
refractive index 
1.5542 (estimate)
storage temp. 
Refrigerator
solubility 
Soluble in alcohol or chloroform
form 
neat
Water Solubility 
6mg/L(22.5 ºC)
CAS DataBase Reference
42924-53-8(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
LW0TIW155Z
NIST Chemistry Reference
Nabumetone(42924-53-8)
SAFETY
  • Risk and Safety Statements
Hazard statements  H303
Hazard Codes  Xn
Risk Statements  22-40
Safety Statements  36/37
WGK Germany  2
RTECS  EL9085000
HS Code  2914500000

Nabumetone price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N6142 Nabumetone analytical standard 42924-53-8 5g $113 2019-12-02 Buy
Sigma-Aldrich 1449518 Nabumetone United States Pharmacopeia (USP) Reference Standard 42924-53-8 200mg $352.8 2019-12-02 Buy
Alfa Aesar J63072 Nabumetone 42924-53-8 5g $87.4 2020-06-24 Buy
Alfa Aesar J63072 Nabumetone 42924-53-8 25g $284 2020-06-24 Buy
Cayman Chemical 20251 Nabumetone ≥98% 42924-53-8 1g $25 2020-06-24 Buy

Nabumetone Chemical Properties,Uses,Production

Description

Nabumetone is a non-acidic, nonsteroidal antiinflammatory agent formally related to naproxen. Its main circulating metabolite is 6-methoxy-2-naphthylacetic acid (α-nornaproxen). Administered once daily (Tsub>1/2 * 30 hrs), nabumetone is reported to be effective in the treatment of rheumatoid and osteoarthritis.

Chemical Properties

White Powder

Originator

Beecham (United Kingdom)

Uses

Anti-inflammatory. Antibacterial.

Uses

anesthetic (local)

Uses

Anti-inflamatory. Antibacterial

Definition

ChEBI: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is s own to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.

Indications

Nabumetone (Relafen) is approved for rheumatoid arthritis, osteoarthritis, and pain management. Its long half-life allows for once-daily dosing. Although this drug is a weak inhibitor of COX, it is metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), a strong COX inhibitor that is chemically similar to naproxen. As with most NSAIDs, GI side effects are most commonly reported. The incidence of gastric ulceration is lower with nabumetone than with many other NSAIDs.This is due to its nature as a prodrug, not to COX-2 selectivity. Lower-bowel complaints, rashes, and CNS disturbances are common adverse effects.

brand name

Relafen (Smith-Kline Beecham);RELIFEX.

General Description

Nabumetone (Relafen), a nonacidic NSAID prodrug, isclassified as an arylacetic acid, because it undergoes rapidhepatic metabolism to its active metabolite, 6-methoxy-2-naphthylacetic acid. Similar to the other arylacetic aciddrugs, it is used in short- or long-term management of RAand OA. Being nonacidic, it does not produce significantprimary insult to the GI mucosa lining and also has no effecton prostaglandin synthesis in gastric mucosa, thus producingminimum secondary GI damage when comparedwith other conventional NSAIDs.

Pharmacokinetics

Nabumetone is absorbed primarily from the duodenum. Milk and food increase the rate of absorption and the bioavailability of the active metabolite. Plasma concentrations of unchanged drug are too low to be detected in most subjects after oral administration, so most pharmacokinetic studies have involved the disposition of the active metabolite. Pharmacokinetic properties are altered in elderly patients, with higher plasma levels of the active metabolite being noted. Nabumetone undergoes rapid and extensive metabolism in the liver, with a mean absolute bioavailability of the active metabolite of 38%. The metabolism of nabumetone is illustrated in Figure 36.15. The major, most active metabolite is 6MNA, but the initial alcohol metabolite, a minor product, and its esters also possess significant anti-inflammatory properties.

Clinical Use

Nabumetone is indicated for the acute and chronic treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis. The recommended starting dosage is 1,000 mg as a single dose with or without food. More symptomatic relief of severe or persistent symp-toms may be obtained at doses of 1,500 or 2,000 mg/day

Nabumetone Preparation Products And Raw materials

Raw materials

Preparation Products


Nabumetone Suppliers

Global( 186)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 10277 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132149 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32444 55

View Lastest Price from Nabumetone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-29 Nabumetone
42924-53-8
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2018-08-20 Nabumetone
42924-53-8
US $1.00 / KG 1G 98% 100KG career henan chemical co

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