ChemicalBook
Chinese Japanese Germany

Levodopa

Levodopa
Levodopa
CAS No.
59-92-7
Chemical Name:
Levodopa
Synonyms
Dopar;l-dop;Parda;L-DOPA;Doparl;Doprin;Ledopa;Levopa;Beldopa;Bendopa
CBNumber:
CB2402938
Molecular Formula:
C9H11NO4
Formula Weight:
197.19
MOL File:
59-92-7.mol

Levodopa Properties

Melting point:
276-278 °C(lit.)
alpha 
-11.7 º (c=5.3, 1N HCl)
Boiling point:
334.28°C (rough estimate)
Density 
1.3075 (rough estimate)
refractive index 
-12 ° (C=5, 1mol/L HCl)
storage temp. 
2-8°C
form 
Crystalline Powder
pka
2.32(at 25℃)
color 
White to creamy
Water Solubility 
Slightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol.
Merck 
14,5464
BRN 
2215169
Stability:
Stable. Incompatible with strong oxidizing agents. Light and air sensitive.
InChIKey
WTDRDQBEARUVNC-LURJTMIESA-N
CAS DataBase Reference
59-92-7(CAS DataBase Reference)
NIST Chemistry Reference
Levodopa(59-92-7)
EPA Substance Registry System
L-Tyrosine, 3-hydroxy-(59-92-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  AY5600000
10-23
TSCA  Yes
Hazardous Substances Data 59-92-7(Hazardous Substances Data)
Toxicity LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Levodopa price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D9628 3,4-Dihydroxy-L-phenylalanine ≥98% (TLC) 59-92-7 5g $51.9 2017-11-08 Buy
Sigma-Aldrich 1361009 Levodopa United States Pharmacopeia (USP) Reference Standard 59-92-7 200mg $348.4 2017-11-08 Buy
TCI Chemical D0600 3-(3,4-Dihydroxyphenyl)-L-alanine >98.0%(HPLC)(T) 59-92-7 5g $31 2017-11-08 Buy
TCI Chemical D0600 3-(3,4-Dihydroxyphenyl)-L-alanine >98.0%(HPLC)(T) 59-92-7 25g $83 2017-11-08 Buy
Alfa Aesar A11311 3,4-Dihydroxy-L-phenylalanine, 98+% 59-92-7 25g $112 2017-11-08 Buy

Levodopa Chemical Properties,Uses,Production

Chemical Properties

Colorless Crystalline Powder

Uses

antiparkinsonian

Uses

An immediate precursor of dopamine and product of tyrosine hydroxylase.

Uses

Natural isomer of the immediate precursor of dopamine; product of tyrsine hydroxylase

Definition

ChEBI: An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease

Biological Activity

Immediate precursor of dopamine, produced by tyrosine hydroxylase. Displays antiParkinsonian activity.

Purification Methods

Likely impurities are vanillin, hippuric acid, 3-methoxytyrosine and 3-aminotyrosine. DOPA recrystallises from large volumes of H2O forming colourless white needles; its solubility in H2O is 0.165%, but it is insoluble in EtOH, *C6H6, CHCl3, and EtOAc. Also crystallise it by dissolving it in dilute HCl and adding dilute ammonia to give pH 5, under N2. Alternatively, crystallise it from dilute aqueous EtOH. It is rapidly oxidised in air when moist, and darkens, particularly in alkaline solution. Dry it in vacuo at 70o in the dark, and store it in a dark container preferably under N2. It has at 220.5nm (log 3.79) and 280nm (log 3.42) in 0.001N max HCl. [Yamada et al. Chem Pharm Bull Jpn 10 693 1962, Bretschneider et al. Helv Chim Acta 56 2857 1973, NMR: Jardetzky & Jardetzky J Biol Chem 233 383 1958, Beilstein 4 IV 2492, 2493.]

Levodopa Preparation Products And Raw materials

Raw materials

Preparation Products


Levodopa Suppliers

Global( 338)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22144 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20803 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32765 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 660 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales1@fine-chemtech.com CHINA 893 55
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 300 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3625 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 10012 58

View Lastest Price from Levodopa manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-06 Levodopa
59-92-7
US $1.00 / KG 1KG 99% 1ton
2018-08-06 Levodopa
59-92-7
US $1.00 / KG 1KG 98% 200KG

59-92-7(Levodopa)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved