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Tianeptine

CAS No.
66981-73-5
Chemical Name:
Tianeptine
Synonyms
Tianeptine hemisulfate monohydrate;Tianeptineacid;Tianeptine powder;COAXIL;TIANEPTINE;Tianeptina;Tianeotine;Brn 1232295;Tianeptinum;Thiempirtine
CBNumber:
CB3217470
Molecular Formula:
C21H25ClN2O4S
Molecular Weight:
436.95
MDL Number:
MFCD00865376
MOL File:
66981-73-5.mol

Tianeptine Properties

Melting point 129-131°C
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Freely soluble in water, in methanol and in methylene chloride.
form Solid
color White to Off-White
CAS DataBase Reference 66981-73-5(CAS DataBase Reference)
FDA UNII 0T493YFU8O
ATC code N06AX14

SAFETY

Risk and Safety Statements

RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

Tianeptine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology A3873 Tianeptine 66981-73-5 5mg $92 2021-12-16 Buy
ApexBio Technology A3873 Tianeptine 66981-73-5 50mg $430 2021-12-16 Buy
Medical Isotopes, Inc. 13823 Tianeptine 66981-73-5 10mg $875 2021-12-16 Buy
AccelPharmtech AT4400 Tianeptine 99.00% 66981-73-5 1KG $4050 2021-12-16 Buy
AccelPharmtech AT4400 Tianeptine 99.00% 66981-73-5 10KG $36800 2021-12-16 Buy
Product number Packaging Price Buy
A3873 5mg $92 Buy
A3873 50mg $430 Buy
13823 10mg $875 Buy
AT4400 1KG $4050 Buy
AT4400 10KG $36800 Buy

Tianeptine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Stablon,Servier,France,1983

Uses

Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant

Manufacturing Process

A solution of 27.6 g (0.16 mol) of freshly distilled ethyl 7-aminoheptanoate in 40 ml of nitromethane was added all at once and with mechanical stirring to a suspension of 26.2 g (0.08 mol) of 5,8-dichloro-10-dioxo-11- methyldibenzo[c,f]thiazepine(1,2) in 120 ml of nitromethane. The whole was heated to 55°C for 30 minutes, the solvent was then evaporated in vacuo and the residue was taken up in water. The crude ester was extracted with ether. After evaporation of the ether 36 g of crude ester were obtained, and 30 g (0.065 mol) there of were treated under reflux with a solution of 2.8 g (0.07 mol) of sodium hydroxide in 35 ml of ethanol and 25 ml of water. After one hour's refluxing, the alcohol was evaporated in vacuo. The residue was taken up in 150 ml of water.
The mixture was twice extracted with 75 ml of chloroform and the aqueous phase was evaporated in vacuo. The sodium salt was then dissolved in 150 ml of chloroform, the solution was dried over sodium sulfate and the product precipitated with anhydrous ether.
The salt was filtered off, washed with ether and dried at 50°C. 13 g of sodium 7-[8-chloro-10-dioxo-11-methyldibenzo[c,f]thiazepin-(1,2)-aminoheptanoate,melting with decomposition at about 180°C, were obtained.

Therapeutic Function

Antidepressant

Tianeptine Preparation Products And Raw materials

Global( 272)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Aoliqisi New Material Technology Co., Ltd.
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View Lastest Price from Tianeptine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-08-06 Tianeptine
66981-73-5
US $0.00-0.00 / kg 1kg 98%+ 10000kgs Shanghai Qyubiotech Co., Ltd.
2022-07-28 Tianeptine
66981-73-5
US $200.00 / g 10g 99% 25kg/ month Wuhan Qiami Technology Co., Ltd
2022-07-22 Tianeptine
66981-73-5
US $0.00 / kg 1kg 99.9% 20 tons/month Taiyuan CJ Trading Co., Ltd
  • Tianeptine
    66981-73-5
  • US $0.00-0.00 / kg
  • 98%+
  • Shanghai Qyubiotech Co., Ltd.
  • Tianeptine
    66981-73-5
  • US $200.00 / g
  • 99%
  • Wuhan Qiami Technology Co., Ltd
  • Tianeptine
    66981-73-5
  • US $0.00 / kg
  • 99.9%
  • Taiyuan CJ Trading Co., Ltd
TIANEPTINE 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)-amino]heptanoic acid s,s-dioxide 7-[(3-CHLORO-6,11-DIHYDRO-6-METHYL-DIBENZO[C,F][1,2]THIAZEPINE-11-YL)AMINO]HEPTANOIC ACID S,S DIOXIDE COAXIL 7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-y1)amino]heptanoic acid S,S-dioxide 30123-17-2 (Mono-hydrochloride salt) Brn 1232295 Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyldibenzo(E,F)(1,2)thiazapin-11-yl)amino)-, S,S-dioxide Tianeptina Tianeptina [inn-spanish] Tianeptinum Tianeptine-d4 Tianeotine Heptanoic acid,7-[(3-chloro-6,11-dihydro-6-Methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)aMino]- Tianeptine 7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)-amino]heptanoic acid S,S-dioxide 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid Thiempirtine Sodium Tianeptine for system suitability CRS Raw Material Tianeptine Acid Tianeptine crystal Tianeptine(INN) Tianeptine USP/EP/BP tianeptine sodium tianeptine sulfate Tianeptine acid Tianeptineacid Tianeptine hemisulfate monohydrate Tianeptine powder 66981-73-5 C21H25ClN2O4S Tianeptine API Tianeptine Intermediates Pharmaceuticals Heterocyclic Compounds Intermediates & Fine Chemicals Intermediate