Tianeptine
- CAS No.
- 66981-73-5
- Chemical Name:
- Tianeptine
- Synonyms
- Tianeptine hemisulfate monohydrate;Tianeptineacid;Tianeptine powder;COAXIL;Tianepine;Tianeptina;Tianeotine;Brn 1232295;Tianeptinum;Thiempirtine
- CBNumber:
- CB3217470
- Molecular Formula:
- C21H25ClN2O4S
- Molecular Weight:
- 436.95
- MDL Number:
- MFCD00865376
- MOL File:
- 66981-73-5.mol
Melting point | 129-131°C |
---|---|
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | Freely soluble in water, in methanol and in methylene chloride. |
form | Solid |
color | White to Off-White |
InChIKey | JICJBGPOMZQUBB-UHFFFAOYSA-N |
SMILES | C(O)(=O)CCCCCCNC1C2=CC=C(Cl)C=C2S(=O)(=O)N(C)C2=CC=CC=C21 |
CAS DataBase Reference | 66981-73-5(CAS DataBase Reference) |
FDA UNII | 0T493YFU8O |
ATC code | N06AX14 |
Tianeptine price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ApexBio Technology | A3873 | Tianeptine | 66981-73-5 | 5mg | $92 | 2021-12-16 | Buy |
ApexBio Technology | A3873 | Tianeptine | 66981-73-5 | 50mg | $430 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 13823 | Tianeptine | 66981-73-5 | 10mg | $875 | 2021-12-16 | Buy |
AccelPharmtech | AT4400 | Tianeptine 99.00% | 66981-73-5 | 1KG | $4050 | 2021-12-16 | Buy |
AccelPharmtech | AT4400 | Tianeptine 99.00% | 66981-73-5 | 10KG | $36800 | 2021-12-16 | Buy |
Tianeptine Chemical Properties,Uses,Production
Description
Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake and is similar to amineptine. Tianeptine does not have a noted effect on monoamine uptake.
Chemical Properties
White Solid
Originator
Stablon,Servier,France,1983
Uses
Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant
Uses
Tianeptine is used in the treatment of reactive and neurotic depression, as well as in the treatment of anxious states.
Definition
ChEBI: Tianeptine is a racemate comprising of equimolar amounts of (R)- and (S)-tianeptine. It is an atypical antidepressant used in Europe to treat patients who respond poorly to selective serotonin reuptake inhibitors (SSRIs). It has a role as a mu-opioid receptor agonist, a second generation antipsychotic and an anxiolytic drug. It contains a (R)-tianeptine and a (S)-tianeptine.
Manufacturing Process
A solution of 27.6 g (0.16 mol) of freshly distilled ethyl 7-aminoheptanoate in
40 ml of nitromethane was added all at once and with mechanical stirring to a
suspension of 26.2 g (0.08 mol) of 5,8-dichloro-10-dioxo-11-
methyldibenzo[c,f]thiazepine(1,2) in 120 ml of nitromethane. The whole was
heated to 55°C for 30 minutes, the solvent was then evaporated in vacuo and
the residue was taken up in water. The crude ester was extracted with ether.
After evaporation of the ether 36 g of crude ester were obtained, and 30 g
(0.065 mol) there of were treated under reflux with a solution of 2.8 g (0.07
mol) of sodium hydroxide in 35 ml of ethanol and 25 ml of water. After one
hour's refluxing, the alcohol was evaporated in vacuo. The residue was taken
up in 150 ml of water.
The mixture was twice extracted with 75 ml of chloroform and the aqueous
phase was evaporated in vacuo. The sodium salt was then dissolved in 150 ml
of chloroform, the solution was dried over sodium sulfate and the product
precipitated with anhydrous ether.
The salt was filtered off, washed with ether and dried at 50°C. 13 g of sodium
7-[8-chloro-10-dioxo-11-methyldibenzo[c,f]thiazepin-(1,2)-aminoheptanoate,melting with decomposition at about 180°C, were obtained.
Therapeutic Function
Antidepressant
Tianeptine Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 885 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29919 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2530 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6506 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 964 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86-13288715578 +86-13231137666 | sales@hbmojin.com | China | 12409 | 58 |
Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 59 | 58 |
Dorne Chemical Technology co. LTD | +8618560316533 | Ethan@dornechem.com | China | 291 | 58 |
Xi'an ZB Biotech Co.,Ltd | +8618591943808 | sales01@xazbbio.com | China | 819 | 58 |
Related articles
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- Oct 11,2022
View Lastest Price from Tianeptine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-19 | Tianeptine
66981-73-5
|
US $1.50-0.60 / g | 10g | 99% | 600tons | Hebei Dangtong Import and export Co LTD | ||
2024-03-19 | Tianeptine Ethyl Ester
66981-73-5
|
US $50.00 / g | 1g | ≥ 99.0% | 20 tons | Jinan Jianfeng Chemical Co., Ltd | ||
2024-03-18 | Tianeptine acid
66981-73-5
|
US $0.00 / kg | 1kg | 0.99 | 10T | Shandong Hanjiang Chemical Co., Ltd |
- Tianeptine
66981-73-5
- US $1.50-0.60 / g
- 99%
- Hebei Dangtong Import and export Co LTD
- Tianeptine Ethyl Ester
66981-73-5
- US $50.00 / g
- ≥ 99.0%
- Jinan Jianfeng Chemical Co., Ltd
- Tianeptine acid
66981-73-5
- US $0.00 / kg
- 0.99
- Shandong Hanjiang Chemical Co., Ltd
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