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Neosperidin dihydrochalcone

Neosperidin dihydrochalcone
Neosperidin dihydrochalcone
Chemical Name:
Neosperidin dihydrochalcone
E-959;Neo-DHC;FEMA 3811;nci-c60764;Neohesperidin DC;Neohesperidin DHC;NEOHESPERIDINE DC;Neohesperidin DC(NHDC);Neohesperidine hydrate;Neohesperidin DC: HPLC
Molecular Formula:
Formula Weight:
MOL File:

Neosperidin dihydrochalcone Properties

Melting point:
156-158 °C(lit.)
storage temp. 
Practically insoluble in water, freely soluble in dimethyl sulfoxide, soluble in methanol, practically insoluble in methylene chloride.
light yellow
Water Solubility 
CAS DataBase Reference
20702-77-6(CAS DataBase Reference)
EPA Substance Registry System
1-Propanone, 1-[4-[[2-O-(6-deoxy-.alpha.- L-mannopyranosyl)-.beta.- D-glucopyranosyl]oxy]-2,6- dihydroxyphenyl]-3-(3-hydroxy- 4-methoxyphenyl)-(20702-77-6)


WGK Germany  3
RTECS  LZ5785000
HS Code  29389090

Neosperidin dihydrochalcone price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 75041 Neohesperidin dihydrochalcone analytical standard 20702-77-6 100mg $71.6 2018-11-20 Buy
Sigma-Aldrich 1458053 Neohesperidin dihydrochalcone United States Pharmacopeia (USP) Reference Standard 20702-77-6 100mg $330.75 2018-11-20 Buy
TCI Chemical N0675 Neohesperidin Dihydrochalcone Hydrate >98.0%(T) 20702-77-6 5g $119 2018-11-22 Buy
TCI Chemical N0675 Neohesperidin Dihydrochalcone Hydrate >98.0%(T) 20702-77-6 25g $348 2018-11-22 Buy
Alfa Aesar J62922 Neohesperidin dihydrochalcone hydrate, 98+% 20702-77-6 25g $493 2018-11-13 Buy

Neosperidin dihydrochalcone Chemical Properties,Uses,Production

Chemical Properties


Chemical Properties

Neohesperidin dihydrochalcone occurs as a white or yellowishwhite powder with an intensely sweet taste.


Preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit. It is used as sweetening agent, especially in chewing gum and dentifrices.

Production Methods

Neohesperidin dihydrochalcone is synthesized commercially from either of the bitter-flavanones neohesperidin or naringin by catalytic hydrogenation under alkaline conditions in a process first described in the 1960s, in which neohesperidin is purified by recrystallization from water solutions.Neohesperidin dihydrochalcone is obtained by the alkaline hydrogenation of neohesperidin.


ChEBI: A member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange.


Sweetening agent, especially in chewing gum and dentifrices.

General Description

Off-white crystals or powder. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Neosperidin dihydrochalcone is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fire Hazard

The flash point of Neosperidin dihydrochalcone has not been determined, but Neosperidin dihydrochalcone is probably combustible.

Pharmaceutical Applications

Neohesperidin dihydrochalcone is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin. Structurally it is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium). Neohesperidin dihydrochalcone is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer. The sweetness profile is characterized by a lingering sweet/menthol-like aftertaste.The typical level used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum. Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.
In pharmaceutical applications, neohesperidin dihydrochalcone is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins. In antacid preparations, levels of 10–30 ppm result in improved palatability.


Neohesperidin dihydrochalcone is accepted for use in food products either as a sweetener or flavor modifier in a number of areas including Europe, USA, Australia, New Zealand, and several countries in Africa and Asia. It is also used in a number of oral pharmaceutical formulations.
Animal toxicity studies suggest that neohesperidin dihydrochalcone is a nontoxic, nonteratogenic, and noncarcinogenic material at the levels used in foods and pharmaceuticals.In Europe, an acceptable daily intake of 0–5 mg/kg body-weight has been established.


Neohesperidin dihydrochalcone is stable for over three years when stored at room temperature.
Accelerated stability studies on aqueous solutions stored at 30–60°C and pH 1–7 for 140 days indicate that neohesperidin dihydrochalcone solutions are likely to be stable for 12 months at room temperature and pH 2–6.Solutions formulated with some or all of the water replaced by solvents with a lower dielectric constant are reported to have longer shelf-lives.
The bulk material should be stored in a cool, dry, place protected from light.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe.

Neosperidin dihydrochalcone Preparation Products And Raw materials

Raw materials

Preparation Products

Neosperidin dihydrochalcone Suppliers

Global( 213)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001 CHINA 18004 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2238 58
career henan chemical co
+86-371-86658258 CHINA 19990 58
Kono Chem Co., Ltd
+86-132 8924 6953 CHINA 2164 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3624 58
Sichuan Benepure Pharmaceutical Co., Ltd. 028-86799990 86799914
028-86799924 China 119 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76

View Lastest Price from Neosperidin dihydrochalcone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Neosperidin dihydrochalcone
US $8.00 / kg 1kg 99% 100KG career henan chemical co

Neosperidin dihydrochalcone Spectrum

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