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Neosperidin dihydrochalcone

CAS No.
20702-77-6
Chemical Name:
Neosperidin dihydrochalcone
Synonyms
E-959;Neo-DHC;FEMA 3811;nci-c60764;Happy Sweet;Neohesperidin DC;Neohesperidin DHC;NEOHESPERIDINE DC;Hesperidin Impurity 4;Neohesperidin DC(NHDC)
CBNumber:
CB3218194
Molecular Formula:
C28H36O15
Molecular Weight:
612.58
MDL Number:
MFCD00017711
MOL File:
20702-77-6.mol
Last updated:2023-12-05 17:42:12

Neosperidin dihydrochalcone Properties

Melting point 156-158 °C(lit.)
Boiling point 927.1±65.0 °C(Predicted)
Density 1.61±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 20℃
FEMA 3811 | NEOHESPERIDIN DIHYDROCHALCONE
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Practically insoluble in water, freely soluble in dimethyl sulfoxide, soluble in methanol, practically insoluble in methylene chloride.
form crystalline
pka 6.85±0.40(Predicted)
color light yellow
Odor at 100.00 %. bland odor
Odor Type odorless
Water Solubility Insoluble
Merck 14,6452
Stability Hygroscopic
InChIKey ITVGXXMINPYUHD-CUVHLRMHSA-N
LogP 0.67 at 20℃
CAS DataBase Reference 20702-77-6(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) NEOHESPERIDIN DIHYDROCHALCONE
EWG's Food Scores 1
FDA UNII 3X476D83QV
EPA Substance Registry System Neohesperidin dihydrochalcone (20702-77-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
WGK Germany  3
RTECS  LZ5785000
HS Code  29389090
NFPA 704
0
2 0

Neosperidin dihydrochalcone price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W381101 Neohesperidin dihydrochalcone ≥96%, FG 20702-77-6 25g $81.9 2024-03-01 Buy
Sigma-Aldrich W381101 Neohesperidin dihydrochalcone ≥96%, FG 20702-77-6 100g $127 2024-03-01 Buy
Sigma-Aldrich 75041 Neohesperidin dihydrochalcone analytical standard 20702-77-6 100mg $101 2024-03-01 Buy
Sigma-Aldrich 1458053 Neohesperidin dihydrochalcone United States Pharmacopeia (USP) Reference Standard 20702-77-6 100mg $75.8 2021-12-16 Buy
TCI Chemical N0675 Neohesperidin Dihydrochalcone Hydrate >98.0%(T) 20702-77-6 5g $119 2024-03-01 Buy
Product number Packaging Price Buy
W381101 25g $81.9 Buy
W381101 100g $127 Buy
75041 100mg $101 Buy
1458053 100mg $75.8 Buy
N0675 5g $119 Buy

Neosperidin dihydrochalcone Chemical Properties,Uses,Production

Chemical Properties

Neohesperidin dihydrochalcone occurs as a white or yellowish white powder with an intensely sweet taste. The sweetness is about 1500-1800 times that of sucrose, and its sweetness time is slightly later than saccharin sodium and much faster than glycyrrhizin (5:7:23s). The sweetness retention time of the three is 42:57:133s, which is also between Between the two, it is closer to sodium saccharin. It is soluble in water, slightly soluble in ethanol, but insoluble in ether and benzene.

Uses

Neohesperidin dihydrochalcone hydrate, is a flavonoid sweetening agent with potent antioxidant activity. It is antioxidant agent. artificial sweetener, especially in chewing gum and dentifrices.

Uses

Preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit. It is used as sweetening agent, especially in chewing gum and dentifrices.

Production Methods

Neohesperidin dihydrochalcone is synthesized commercially from either of the bitter-flavanones neohesperidin or naringin by catalytic hydrogenation under alkaline conditions in a process first described in the 1960s, in which neohesperidin is purified by recrystallization from water solutions.Neohesperidin dihydrochalcone is obtained by the alkaline hydrogenation of neohesperidin.

Definition

ChEBI: Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange. It has a role as an environmental contaminant, a xenobiotic, a plant metabolite and a sweetening agent. It is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.

General Description

Off-white crystals or powder. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Neosperidin dihydrochalcone is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fire Hazard

The flash point of Neosperidin dihydrochalcone has not been determined, but Neosperidin dihydrochalcone is probably combustible.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Neohesperidin dihydrochalcone is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin. Structurally it is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium). Neohesperidin dihydrochalcone is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer. The sweetness profile is characterized by a lingering sweet/menthol-like aftertaste.The typical level used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum. Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.
In pharmaceutical applications, neohesperidin dihydrochalcone is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins. In antacid preparations, levels of 10–30 ppm result in improved palatability.

Safety

Neohesperidin dihydrochalcone is accepted for use in food products either as a sweetener or flavor modifier in a number of areas including Europe, USA, Australia, New Zealand, and several countries in Africa and Asia. It is also used in a number of oral pharmaceutical formulations.
Animal toxicity studies suggest that neohesperidin dihydrochalcone is a nontoxic, nonteratogenic, and noncarcinogenic material at the levels used in foods and pharmaceuticals.In Europe, an acceptable daily intake of 0–5 mg/kg body-weight has been established.

storage

Neohesperidin dihydrochalcone is stable for over three years when stored at room temperature.
Accelerated stability studies on aqueous solutions stored at 30–60°C and pH 1–7 for 140 days indicate that neohesperidin dihydrochalcone solutions are likely to be stable for 12 months at room temperature and pH 2–6.Solutions formulated with some or all of the water replaced by solvents with a lower dielectric constant are reported to have longer shelf-lives.
The bulk material should be stored in a cool, dry, place protected from light.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe.

Neosperidin dihydrochalcone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 483)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024 hibo06@xaltbio.com China 1000 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Wuhan Haorong Biotechnology Co.,ltd
+8618565342920 sales@chembj.net China 268 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14770 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58

View Lastest Price from Neosperidin dihydrochalcone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Neosperidin dihydrochalcone pictures 2024-03-19 Neosperidin dihydrochalcone
20702-77-6
US $0.00-0.00 / KG 1KG 99% 5000 Wuhan Haorong Biotechnology Co.,Ltd
Neosperidin dihydrochalcone pictures 2024-03-01 Neosperidin dihydrochalcone
20702-77-6
US $0.00 / KG 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Neosperidin dihydrochalcone pictures 2023-12-05 Neosperidin dihydrochalcone
20702-77-6
US $0.00-0.00 / kg 1kg 98% 50000kg/Month Shaanxi Haibo Biotechnology Co., Ltd
Neohesperidin dihydrochalcone ,EP Neohesperidin dihydrochalcone, froM Citrus MaxiMa Newhesperidinchalconetwohydrogen Neohesperidin dihydrochalcone SynonyMs 1-(4-((2-O-[6-Deoxy-alpha-L-Mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-Methoxyphenyl]-1-propanone 1-Propanone, 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)- Neohesperidine Dihydrochalcone (100 mg) 1-Propanone, 1-4-2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-2,6-dihydroxyphenyl-3-(3-hydroxy-4-methoxyphenyl)- 1-(4-((2-o-[6-deoxy-α-l-mannopyranosyl]-β-d-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone Neohesperidin Dihydrochalcone ( NHDC ) BETA-NEOHESPERIDINDIHYDROCHALCONE 1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone Neohesperidin DC neohesperidi dihydrochalcone 1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-prop Neo-DHC Neohesperidin DC(NHDC) neosperidin dihydrochalcone 1-Propanone, 1-[4-[[2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)- Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-a-L-mannopyranosyl)-, b-D- Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-a-L-rhamnopyranosyl- Neohesperidin DHC 1-[4-[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyloxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propane-1-one 1-[4-[2-O-(α-L-Rhamnopyranosyl)-β-D-glucopyranosyloxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone 3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside Neohesperidin DC: HPLC96% Min Neohesperidin dihydrochalcone,1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone NEOHESPERIDIN DIHYDROCHALCONE NEOHESPERIDIN DIHYDROCHALCONE HYDRATE NEOHESPERIDINE DC NEOHESPERIDINE DIHYDROCHALCONE NEOHESPERIDINE DIHYDROCHALCONE HYDRATE 1-[4-[[2-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-2,6-DIHYDROXYPHENYL]-3-(3-HYDROXY-4-METHOXYPHENYL)-1-PROPANONE FEMA 3811 E-959 beta-d--(6-deoxy-alpha-l-mannopyranosyl) glucopyranoside,3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-o nci-c60764 neohesperidin dihydrochalcone from*citrus fruit Neosperidin Dihydro halcone Neohesperidine hydrate Neohesperidin dihydrochalcone hydrate ,98% NEOHESPERIDIN DIHYDROCHALCONE 85+% Neohesperidin DC: HPLC 1-[4-[[2-O-(6-Deoxy-α-L-Mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-Methoxyphenyl)- 1-(4-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxyMethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-Methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-Methoxyphenyl)propan-1-one NEDC Neohesperidin dihydrochalcone Neohesperidin dihydrochalcone, 99%, from Citrus maxima Neohesperidin-dihydrochalcone CRS NeohesperidinDihydrochalconeHydrate> Hesperidin Impurity 4 NHP-DC, NEOHESPERIDIN DIHYDROCHALCONE Neosperidin dihydrochalcone USP/EP/BP Water-Soluble NEOHESPERIDIN DIHYDROCHALCONE(NHDC) 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one 4-Chloro-3,5-dimethylphenol 88-04-0 1-Propanone, 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)- New hesperidin dihydrochalcone Happy Sweet