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Raspberry Ketone

Chemical properties Uses Production method
Raspberry Ketone
Raspberry Ketone structure
Chemical Name:
Raspberry Ketone
OXANONE;Rheosmin;Frambione;NSC 26515;FEMA 2588;Rasketone;OXYPHENONE;Frambinone;OXYPHENYLON;Oxyphenalon
Molecular Formula:
Formula Weight:
MOL File:

Raspberry Ketone Properties

Melting point:
81-85 °C (lit.)
Boiling point:
1.0326 (rough estimate)
refractive index 
1.5250 (estimate)
storage temp. 
under inert gas (argon)
95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan
Clear colorless
Water Solubility 
Insoluble in water.
JECFA Number
Substances Added to Food (formerly EAFUS)
CAS DataBase Reference
5471-51-2(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2)
EPA Substance Registry System
2-Butanone, 4-(4-hydroxyphenyl)- (5471-51-2)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H301-H302
Precautionary statements  P264-P270-P301+P310a-P321-P405-P501a-P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22
Safety Statements  26-36/37/39-36
WGK Germany  2
RTECS  EL8925000
Hazard Note  Irritant
HS Code  29145011
NFPA 704
1 0

Raspberry Ketone price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W258806 4-(4-Hydroxyphenyl)-2-butanone ≥98%, FCC, FG 5471-51-2 250 g $75 2021-03-22 Buy
Sigma-Aldrich 01416 4-(4-Hydroxyphenyl)-2-butanone certified reference material, TraceCERT 5471-51-2 100mg $79.9 2021-03-22 Buy
Sigma-Aldrich W258814 4-(4-Hydroxyphenyl)-2-butanone natural, ≥98%, FCC, FG 5471-51-2 25 g $84 2021-03-22 Buy
Sigma-Aldrich W258806 4-(4-Hydroxyphenyl)-2-butanone ≥98%, FCC, FG 5471-51-2 1 kg $121 2021-03-22 Buy
Sigma-Aldrich W258806 4-(4-Hydroxyphenyl)-2-butanone ≥98%, FCC, FG 5471-51-2 5 kg $325 2021-03-22 Buy

Raspberry Ketone Chemical Properties,Uses,Production

Chemical properties

It appears as white needle crystal or granular solid, exhibiting raspberry aroma and fruit aroma. The melting point temperature is 82~83 °C. It is insoluble in water and oil, being soluble in alcohol, ether and volatile oil.
The natural products exist in raspberry (raspberry) and so on.


1. Raspberry Ketone is used in the preparation of food spices with sweetening effect, can also be used for cosmetics and soap flavor.
2. Raspberry Ketone is widely used in strawberry, raspberry, pineapple, peaches and other food flavors, usually used as a fixing agent in the fruity flavor. In daily flavor, it can be used in formulations such as jasmine, gardenia flowers and tuberose. As a modifier, it can be used in jasmine, gardenia, tuberose and other fragrant daily flavor. In food flavors, it is mostly used for strawberries, pineapple, peaches, plums, mayberry and other fragrance. In medicine, it is mostly used as intermediates.

Production method

3.5mol 15% sodium hydroxide is first added to the reactor, and 2 mol of acetone and 1mol of p-hydroxybenzaldehyde are added dropwise under stirring. The temperature is controlled between 20 and 30 DEG C, and the stirring reaction is continued for 20 hours. The solid sodium salt of 4-p-hydroxyphenylbutene-3-ketone-2 was obtained after filtering, further dissolved in water, and then acidified with hydrochloric acid to precipitate 4-p-hydroxyphenylbutene-3-ketone-2, further filter and dry for further application.
The autoclave was supplied with 100 g of the intermediate and 5 g of the nickel catalyst, and the atmosphere was replaced with hydrogen. The mixture was heated to 120-140 °C and reacted at a pressure of 0.98 MPa for 1.5 h. After cooling, the catalyst was filtered off, the raspberry ketone content was 89% and the hydrogenation yield was 92%. The crude product above is subject to vacuum distillation once with further recrystallization of 1-2 times getting white crystals with the melting point of 82 ° C.
Phenol route
94g phenol and 85% phosphoric acid mixed catalyst were added into the reactor, 70g methyl vinyl ketone was added dropwise in 40min, the temperature was maintained at 15-20 ℃, and the reaction was stirred for 4h. After completion of the reaction, the reaction mixture was washed with water until neutral, and 63 g of phenol was distilled off under reduced pressure to obtain 25 g of a product having a melting point of 81.5 to 82.5 ° C and a yield of 80%.
It is obtained through the condensation between hydroxybenzaldehyde and acetone and further hydrogenation.
It is obtained through the condensation between the ketone acid and phenol.


4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves odor. May be prepared by catalytic hydrogenation of phydroxy-benzylidene acetone in the presence of platinum black in ether or methanol or in the presence of palladium absorbed on charcoal.

Chemical Properties

4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves–type odor.

Chemical Properties

4-(4-Hydroxyphenyl)-2-butanone is a highly characteristic component of raspberry aroma. It forms colorless crystals (mp 82–83°C) with a sweet, fruity odor strongly reminiscent of raspberries. Raspberry ketone is prepared by alkali-catalyzed condensation of the alkali salt of 4-hydroxybenzaldehyde and acetone, followed by selective hydrogenation of the double bond in the resulting 4-hydroxybenzalacetone. Other syntheses start from phenol, which is converted into 4-(4-hydroxyphenyl)-2-butanone with methyl vinyl ketone or with 4-hydroxy-2-butanone.

Chemical Properties

white to slightly yellow powder or needles


Reported found European cranberry, raspberry, blackberry, loganberry and sea buckthorn (Hippophae rhamnoides L.).


The primary aroma compound of red raspberries, used in perfume compositions, shampoos, cosmetics and as a food additive. Also an impurity in the synthesis of Dobutamine (D494445).


Intermediates of Liquid Crystals


ChEBI: A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics.

Taste threshold values

Taste characteristics at 40 ppm: fruity, jamy, berry, raspberry, and blueberry with seedy, cotton candy nuances

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 1206, 1976 DOI: 10.1021/jo00869a026
Synthetic Communications, 19, p. 1109, 1989 DOI: 10.1080/00397918908051034

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Raspberry Ketone Preparation Products And Raw materials

Raw materials

Preparation Products

Raspberry Ketone Suppliers

Global( 446)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20010 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8881 55
Rixing Chemical CO.,LTD
- CHINA 229 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 3001 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29968 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086 CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897 CHINA 2712 58

Related articles

View Lastest Price from Raspberry Ketone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-07 Raspberry Ketone
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2021-08-26 Raspberry Ketone
US $30.00 / KG 1KG 99% 1 ton Hebei Crovell Biotech Co Ltd
2021-08-10 Raspberry ketone
US $30.00 / Kg 1KG 99% 500ton Shanghai Yunao International Trade Co., Ltd

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