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Raspberry Ketone

Chemical properties Uses Standards for Use of Food Additives Production method

CAS No. 5471-51-2
Chemical Name: Raspberry Ketone
Synonyms: OXANONE;Rheosmin;FEMA 2588;Frambione;NSC 26515;OXYPHENONE;Frambinone;Oxyphenalon;OXYPHENYLON;Raspberry keton
CBNumber: CB9495263
Molecular Formula: C10H12O2
Formula Weight: 164.2
MOL File: 5471-51-2.mol
Raspberry Ketone Property
Melting point : 81-85 °C(lit.)
Boiling point : 200°C
FEMA : 2588
storage temp. : Refrigerator
solubility : 95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan
Water Solubility : Insoluble in water.
BRN : 776080
CAS DataBase Reference: 5471-51-2(CAS DataBase Reference)
NIST Chemistry Reference: 2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2)
EPA Substance Registry System: 2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn,Xi
Risk Statements : 22
Safety Statements : 26-36/37/39
WGK Germany : 2
RTECS : EL8925000
Hazard Note : Irritant
TSCA : Yes
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P321 Specific treatment (see … on this label).
P405 Store locked up.

Raspberry Ketone Chemical Properties,Usage,Production

Chemical properties
It appears as white needle crystal or granular solid, exhibiting raspberry aroma and fruit aroma. The melting point temperature is 82~83 °C. It is insoluble in water and oil, being soluble in alcohol, ether and volatile oil.
The natural products exist in raspberry (raspberry) and so on.
1. GB 2760-96 provides it as allowable food flavors. It is mainly used to prepare raspberry, grapes, strawberries and other types of flavor.
2. Raspberry Ketone is used in the preparation of food spices with sweetening effect, can also be used for cosmetics and soap flavor
3. Raspberry ketone is food spices allowed for use by the China's "food additives use of health standards" and is more used for the preparation of pineapple, peach, strawberry, plum and other fruit flavors. The usage amount used in chewing gum is 40~320mg/kg; baking food: 54mg/kg; candy: 44mg/kg; cold drinks: 34mg/kg; soft drinks: 16mg/kg; pudding class 5.0~50mg/kg.
4. Raspberry Ketone is widely used in strawberry, raspberry, pineapple, peaches and other food flavors, usually used as a fixing agent in the fruity flavor. In daily flavor, it can be used in formulations such as jasmine, gardenia flowers and tuberose. As a modifier, it can be used in jasmine, gardenia, tuberose and other fragrant daily flavor. In food flavors, it is mostly used for strawberries, pineapple, peaches, plums, mayberry and other fragrance. In medicine, it is mostly used as intermediates. Phone 15827146163
Standards for Use of Food Additives
Food additive Raspberry ketone
Food allowed to use it as additive Food
Function of additive Food-purpose spices
Maximal allowable amount(g/kg) Each ingredients of spices for the formulation of flavors should not exceed the maximal allowable residue and maximal allowable amount of food additive provided in GB2760
Maximal allowable residue(g/kg)  
Production method
3.5mol 15% sodium hydroxide is first added to the reactor, and 2 mol of acetone and 1mol of p-hydroxybenzaldehyde are added dropwise under stirring. The temperature is controlled between 20 and 30 DEG C, and the stirring reaction is continued for 20 hours. The solid sodium salt of 4-p-hydroxyphenylbutene-3-ketone-2 was obtained after filtering, further dissolved in water, and then acidified with hydrochloric acid to precipitate 4-p-hydroxyphenylbutene-3-ketone-2, further filter and dry for further application.
The autoclave was supplied with 100 g of the intermediate and 5 g of the nickel catalyst, and the atmosphere was replaced with hydrogen. The mixture was heated to 120-140 °C and reacted at a pressure of 0.98 MPa for 1.5 h. After cooling, the catalyst was filtered off, the raspberry ketone content was 89% and the hydrogenation yield was 92%. The crude product above is subject to vacuum distillation once with further recrystallization of 1-2 times getting white crystals with the melting point of 82 ° C.
Phenol route
94g phenol and 85% phosphoric acid mixed catalyst were added into the reactor, 70g methyl vinyl ketone was added dropwise in 40min, the temperature was maintained at 15-20 ℃, and the reaction was stirred for 4h. After completion of the reaction, the reaction mixture was washed with water until neutral, and 63 g of phenol was distilled off under reduced pressure to obtain 25 g of a product having a melting point of 81.5 to 82.5 ° C and a yield of 80%.
It is obtained through the condensation between hydroxybenzaldehyde and acetone and further hydrogenation.
It is obtained through the condensation between the ketone acid and phenol.
Chemical Properties
white to slightly yellow powder or needles
The primary aroma compound of red raspberries, used in perfume compositions, shampoos, cosmetics and as a food additive. Also an impurity in the synthesis of Dobutamine (D494445).
Intermediates of Liquid Crystals
ChEBI: A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics.
Raspberry Ketone Preparation Products And Raw materials
Raw materials
4,4'-Carbonyldiphthalic acid Etanol Acetone p-Hydroxybenzaldehyde 4-Phenyl-1-butene Methyl vinyl ketone
Preparation Products
Raspberry Ketone Suppliers      Global( 260)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd. +86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19954 60
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 CHINA 3230 55
Zhengzhou HongSheng Pharmaceutical Co., Ltd. 0371-55695890 0371-55697329
0371-63709726 China 4078 58
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 China 1944 62
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96832 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40403 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3589 66
future industrial shanghai co., ltd 021-61552785,400-0066-400
021-55660885 China 2091 65
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30315 84
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 China 22833 81
5471-51-2(Raspberry Ketone)Related Search:
NARIRUTIN 4'-Deoxyphlorizin HOMOERIODICTYOL TAXIFOLIN Piperonyl acetone 2',6'-DIHYDROXY-4,4'-DIMETHOXYDIHYDROCHALCONE Phlorizin 2,3-DIHYDROROBINETIN HESPERETIN DIHYDROCHALCONE ISOSAKURANETIN Raspberry Ketone p-Hydroxybenzaldehyde Methylparaben 4-Hydroxybenzyl alcohol Butyrophenone 4-Hydroxybenzoic acid 2-Butanone (+-) 1-BROMO-2-METHYLBUTANE 95
1-(p-Hydroxyphenyl)-3-butanone 2-Butanone, 4-(p-hydroxyphenyl)- 4-(4-hydroxyphenyl)-2-butanon 4-(p-hydroxyphenyl)-2-butanon 4-p-Hydroxylphenyl)-2-butone Oxyphenalon Rheosmin Raspberry keton RASPBERRY KETONE RASBERRY KETONE OXYPHENONE OXYPHENYLON OXANONE P-HYDROXYBENZYLACETONE P-HYDROXY PHENYL BUTANONE Organic Building Blocks Ketones C10 Carbonyl Compounds Building Blocks 4-(4-HYDROXYPHENYL)BUTAN-2-ONE 4-(4-HYDROXYPHENYL)-2-BUTANONE 4-HYDROXYBENZYLACETONE 5471-51-2 4-(P-HYDROXYPHENYL)-2-BUTANONE HYDROXYPHENYL-2-BUTANONE,4- HYDROXY PHENYL BUTANONE FEMA 2588 4-(4-Hydroxyphenyl)-2-butanone~2-(4-Hydroxyphenyl)ethyl methyl ketone KETONE RASPBERRY KETONE (HYDROXY PHENYLBUTANONE) 4-(P-HYDROXYPHENYL)-2-BUTANONE 98+% & 4-Hydroxybenzylacetone,98% 4-(4-Hydroxyphenyl)-2-butanone, 99+% raspberryketone,1-(p-hydroxyphenyl)-3-butanone 2-Butanone, 4-(4-hydroxyphenyl)- 2-(4-hydroxyphenyl)ethyl methyl ketone PARA-HYDROXYBENZYLACETONE (PARA-HYDROXYPHENYL)BUTAN-2-ONE 4-(PARA-HYDROXYPHENYL)BUTAN-2-ONE 4-(PARA-HYDROXYPHENYL)-2-BUTANONE 4-(4-Hydroxyphenyl)butan-2-on FRAMBINON CRIST. 2-Butanone,4-(4-hydroxyphe Food and Feed Additive Natural rasperry ketone Aromatic Ketones (substituted) 1-(4-Hydroxyphenyl)-3-butanone Frambinone 5741-51-2 HOC6H4CH2CH2COCH3 4-(p-Hydroxylphenyl)-2-butanone 4-(4-Hydroxyphenyl)-2-butanone,Raspberry ketone fructus rubi p.e. Aromatics Raspberry Ketone (100 mg) (4-(4-hydroxyphenyl)-2-butanone) 4-(4-Hydroxyphenyl)-2-butanone, 99+% 50GR 4-(3-Oxobutyl)phenol
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