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Raspberry Ketone

Chemical properties Uses Production method
Raspberry Ketone
Raspberry Ketone structure
Chemical Name:
Raspberry Ketone
OXANONE;Rheosmin;Frambione;NSC 26515;FEMA 2588;OXYPHENONE;Frambinone;OXYPHENYLON;Oxyphenalon;Raspberry keton
Molecular Formula:
Formula Weight:
MOL File:

Raspberry Ketone Properties

Melting point:
81-85 °C(lit.)
Boiling point:
1.0326 (rough estimate)
refractive index 
1.5250 (estimate)
storage temp. 
95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan
Clear colorless
Water Solubility 
Insoluble in water.
JECFA Number
CAS DataBase Reference
5471-51-2(CAS DataBase Reference)
NIST Chemistry Reference
2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2)
EPA Substance Registry System
2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22
Safety Statements  26-36/37/39-36
WGK Germany  2
RTECS  EL8925000
Hazard Note  Irritant
HS Code  29145011
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P321 Specific treatment (see … on this label).
P405 Store locked up.

Raspberry Ketone price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 01416 4-(4-Hydroxyphenyl)-2-butanone certified reference material, TraceCERT 5471-51-2 100mg $73.1 2018-11-13 Buy
Sigma-Aldrich 1598813 Raspberry ketone United States Pharmacopeia (USP) Reference Standard 5471-51-2 100mg $352.8 2018-11-13 Buy
TCI Chemical H0604 4-(4-Hydroxyphenyl)-2-butanone >99.0%(GC) 5471-51-2 25g $40 2018-11-22 Buy
TCI Chemical H0604 4-(4-Hydroxyphenyl)-2-butanone >99.0%(GC) 5471-51-2 250g $215 2018-11-22 Buy
Alfa Aesar A14064 4-(4-Hydroxyphenyl)-2-butanone, 98% 5471-51-2 25g $41 2018-11-15 Buy

Raspberry Ketone Chemical Properties,Uses,Production

Chemical properties

It appears as white needle crystal or granular solid, exhibiting raspberry aroma and fruit aroma. The melting point temperature is 82~83 °C. It is insoluble in water and oil, being soluble in alcohol, ether and volatile oil.
The natural products exist in raspberry (raspberry) and so on.


1. Raspberry Ketone is used in the preparation of food spices with sweetening effect, can also be used for cosmetics and soap flavor.
2. Raspberry Ketone is widely used in strawberry, raspberry, pineapple, peaches and other food flavors, usually used as a fixing agent in the fruity flavor. In daily flavor, it can be used in formulations such as jasmine, gardenia flowers and tuberose. As a modifier, it can be used in jasmine, gardenia, tuberose and other fragrant daily flavor. In food flavors, it is mostly used for strawberries, pineapple, peaches, plums, mayberry and other fragrance. In medicine, it is mostly used as intermediates.

Production method

3.5mol 15% sodium hydroxide is first added to the reactor, and 2 mol of acetone and 1mol of p-hydroxybenzaldehyde are added dropwise under stirring. The temperature is controlled between 20 and 30 DEG C, and the stirring reaction is continued for 20 hours. The solid sodium salt of 4-p-hydroxyphenylbutene-3-ketone-2 was obtained after filtering, further dissolved in water, and then acidified with hydrochloric acid to precipitate 4-p-hydroxyphenylbutene-3-ketone-2, further filter and dry for further application.
The autoclave was supplied with 100 g of the intermediate and 5 g of the nickel catalyst, and the atmosphere was replaced with hydrogen. The mixture was heated to 120-140 °C and reacted at a pressure of 0.98 MPa for 1.5 h. After cooling, the catalyst was filtered off, the raspberry ketone content was 89% and the hydrogenation yield was 92%. The crude product above is subject to vacuum distillation once with further recrystallization of 1-2 times getting white crystals with the melting point of 82 ° C.
Phenol route
94g phenol and 85% phosphoric acid mixed catalyst were added into the reactor, 70g methyl vinyl ketone was added dropwise in 40min, the temperature was maintained at 15-20 ℃, and the reaction was stirred for 4h. After completion of the reaction, the reaction mixture was washed with water until neutral, and 63 g of phenol was distilled off under reduced pressure to obtain 25 g of a product having a melting point of 81.5 to 82.5 ° C and a yield of 80%.
It is obtained through the condensation between hydroxybenzaldehyde and acetone and further hydrogenation.
It is obtained through the condensation between the ketone acid and phenol.

Chemical Properties

white to slightly yellow powder or needles


The primary aroma compound of red raspberries, used in perfume compositions, shampoos, cosmetics and as a food additive. Also an impurity in the synthesis of Dobutamine (D494445).


Intermediates of Liquid Crystals


ChEBI: A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Raspberry Ketone Preparation Products And Raw materials

Raw materials

Preparation Products

Raspberry Ketone Suppliers

Global( 310)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19954 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Rixing Chemical CO.,LTD
- CHINA 235 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 894 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383 CHINA 177 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1662 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2238 58

View Lastest Price from Raspberry Ketone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-07 Raspberry Ketone
US $1.00 / KG 1KG 98% 20KG career henan chemical co

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