Chinese Japanese Germany Korea


Diethylstilbestrol structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Diethylstilbestrol Properties

Melting point:
170-172 °C(lit.)
Boiling point:
351.51°C (rough estimate)
1.1096 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
methanol: 0.1 g/mL, clear, faintly yellow
pKa 9.02(H2O t=25 I=0.025) (Uncertain)
Crystalline Powder
White to almost white
Water Solubility 
Isomerizes rapidly in Benzene, Chloroform, and Ether. Keep Shielded from light.
CAS DataBase Reference
56-53-1(CAS DataBase Reference)
EWG's Food Scores
NCI Dictionary of Cancer Terms
DES; diethylstilbestrol; estrogen
NCI Drug Dictionary
Proposition 65 List
Diethylstilbestrol (DES)
1 (Vol. 21, Sup 7, 100A) 2012
NIST Chemistry Reference
EPA Substance Registry System
Diethylstilbestrol (56-53-1)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H315-H319-H335-H350-H360-H410
Precautionary statements  P201-P280-P305+P351+P338-P308+P313-P261-P273-P501
Hazard Codes  T,N
Risk Statements  45-61-36/37/38-51/53-40
Safety Statements  53-36/37/39-45-60-61-36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  WJ5600000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29072990
Toxicity LD50 oral in rat: > 3gm/kg

Diethylstilbestrol price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46207 Diethylstilbestrol VETRANAL , analytical standard 56-53-1 250mg $43.6 2021-03-22 Buy
Sigma-Aldrich D1500000 Diethylstilbestrol European Pharmacopoeia (EP) Reference Standard 56-53-1 $190 2021-03-22 Buy
Sigma-Aldrich 1195001 Diethylstilbestrol United States Pharmacopeia (USP) Reference Standard 56-53-1 200mg $366 2021-03-22 Buy
Sigma-Aldrich SAB1306249 ANTI-DESMIN(C-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 56-53-1 400UL $389 2021-03-22 Buy
Sigma-Aldrich D4628 Diethylstilbestrol ≥99% (HPLC) 56-53-1 10g $545 2021-03-22 Buy

Diethylstilbestrol Chemical Properties,Uses,Production


Diethylstilbestrol (DES) is a nonsteroidal, synthetic stilbene derivative with estrogenic activity. It is an odorless, white crystalline powder, with a molecular weight of 268.36. Its cisisomer tends to revert to the trans-form.

Chemical Properties

White Solid




A synthetic, nonsteroidal estrogen. Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.


Diethylstilbestrol is a synthetic nonsteroidal estrogen that was formerly used in estrogenic hormone therapy (for menstrual disorders, postpartum breast engorgement, postcoital contraceptive, prevention of spontaneous abortion) and in chemotherapy of various cancers, including postmenopausal breast cancer and prostate cancer. It was also used in biomedical research and veterinary medicine (growth promoter for cattle and sheep; veterinary drug to treat estrogen deficiency disorders).


Diethylstilbestrol is one of the older synthetic estrogens in use. It was used to treat prostate cancer but is now rarely used for this purpose because of its adverse effects,although it is occasionally used in postmenopausal women with breast cancer. It is taken orally in tablet form.

Manufacturing Process

50 parts by weight of p-hydroxypropiophenone are dissolved in 200 parts by weight of a 12.5% solution of caustic soda and shaken with 350 parts by weight of 3% sodium amalgam. The sodium salt of the pinacol thereby precipitating is reacted with glacial acetic acid, whereby the free pinacol is obtained (MP 205°C to 210°C, after purification 215°C to 217°C). The yield amounts to 95% of the theoretical. The pinacol is suspended in ether and gaseous hydrogen chloride introduced, whereby water separates and the pinacolin formed is dissolved in the ether, from which it is obtained by evaporation as a viscous oil (diacetateof MP 91°C). The yield is quantitative.
40 parts by weight of pinacolin are dissolved in ethyl alcohol and gradually treated with 80 parts by weight of sodium under reflux. The solution is decomposed with water and the pinacolin alcohol formed extracted from the neutralized solution with ether. The pinacolin alcohol is a viscous oil which is characterized by a dibenzoate of MP 172°C. The yield is 95% of the theoretical.
A solution of 30 parts by weight of pinacolin alcohol in ether is saturated with hydrogen chloride at room temperature and the ether solution then agitated with bicarbonate. After concentration by evaporation it leaves behind the crude diethylstilbestrol [α,β-(p,p'-dihydroxydiphenyl)-α,β-diethylethylene] which, when recrystallized from benzene, melts at 170°C to 171°C. The yield amounts to 75% of the calculated. The total yield of diethylstilbestrol, calculated on p-hydroxypropiophenone, is 68% of the theoretical.

brand name

Stilbestrol (Tablicaps); Stilbetin (Bristol-Myers Squibb);Distilbene;Oestro-gynedron;Stilphostrol.

Therapeutic Function


World Health Organization (WHO)

Diethylstilbestrol, a synthetic estrogen which is a stilbene derivative, was introduced into obstetric practice in the late 1940s and subsequently widely used for the treatment of threatened abortion. This use was later shown to be associated with an increased risk of vaginal cancer in the offspring which resulted in restrictive regulatory action in several countries. Diethylstilbestrol and other stilbenes remain available in many countries, however, for the treatment of certain hormone-dependent neoplasms including carcinoma of the prostate and postmenopausal breast cancer. (Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977)

General Description

At first glance, it might be surprising that synthetic nonsteroidal molecules such as diethylstilbestrol (DES) could have the same activity as estradiol or other estrogens. DES can be viewed, however, as a form of estradiol with rings B and C open and a six-carbon ring D. The activity of DES analogs was explained in 1946. It was proposed that the distance between the two DES phenol OH groups was the same as the 3-OH to 17-OH distance of estradiol; therefore, they could both fit the same receptor. Medicinal chemists have shown the OH-to-OH distance to be actually 12.1 ? in DES and 10.9 ? in estradiol. In aqueous solution, however, estradiol has two water molecules that are hydrogen bonded to the 17-OH. If one of the two water molecules is included in the distance measurement, there is a perfect fit with the two OH groups of DES. This suggests that water may have an important role for estradiol in its receptor site.
It is now generally accepted that the estrogens must have a phenolic moiety for binding, but some investigators propose that the receptor may be flexible enough to accommodate varying distances between the two key hydroxyls. This point about estrogens needing a phenolic ring for high-affinity binding to the ER is critical. Steroids with a phenolic A ring and related phenolic compounds lack high-affinity binding to the other steroid hormone receptors.

General Description

Odorless tasteless white crystalline powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Diethylstilbestrol is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .

Fire Hazard

Flash point data for Diethylstilbestrol are not available; however, Diethylstilbestrol is probably combustible.

Side effects

These include sodium retention and oedema,nausea,gynaecomastia and impotence in men, and venous and arterial thrombosis. It can cause bone pain and hypercalcaemia when used for breast cancer.

Safety Profile

Confirmed carcinogen producing skin, liver, and lung tumors in exposed humans as well as uterine and other reproductive system tumors in the female offspring of exposed women. Experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. A human teratogen by many routes. Poison by intraperitoneal and subcutaneous routes. It causes glandular system effects by sktn contact. Human reproductive effects by ingestion: abnormalspermatogenesis; changes in testes, epididymis, and sperm duct; menstrual cycle changes or disorders; changes in female ferulity; unspecified maternal effects; developmental abnormalities of the fetal urogenital system; germ cell effects in offspring; and delayed effects in newborn. Implicated in male impotence and enlargement of male breasts. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also ETHINYL ESTRADIOL.


Diethylstilbestrol is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

Environmental Fate

Diethylstilbestrol is a known teratogen and carcinogen. Experimental studies using transgenic estrogen receptor knockout animals suggest that binding and activation of the estrogen receptor is required to elicit diethylstilbestrol toxicity. Hence, diethylstilbestrol lesions primarily appear in tissues enriched with estrogen receptors. Diethylstilbestrol binds to the estrogen receptor with a very high affinity and forms a complex with the target tissue. The complex then internalizes in to the cell and translocates to the nucleus. Once in the nucleus, diethylstilbestrol may directly bind with the cellular DNA and cause mutations and unscheduled DNA synthesis. Diethylstilbestrol is also known to induce aneuploidy.

Toxicity evaluation

Diethylstilbestrol’s production and use in biochemical research, medicine, and veterinary medicine may result in its release to the environment through various waste streams. It may also be released to the environment during transport, storage, or disposal. If released to soil, diethylstilbestrol is predicted to strongly adsorb to the soil. Volatilization from the dry or wet soil surface would probably be unlikely. The extent of biodegradation in soil is not known, although diethylstilbestrol has been shown to be resistant to degradation in activated sludge. If released to water, diethylstilbestrol may bioconcentrate in aquatic organisms and strongly adsorb to suspended solids and sediments. Diethylstilbestrol is expected to be essentially nonvolatile on water surfaces. Diethylstilbestrol would not be susceptible to hydrolysis. The extent of biodegradation in natural waters is not certain, although diethylstilbestrol has been shown to be resistant to degradation in activated sludge. If released to the atmosphere, diethylstilbestrol vapors should rapidly oxidize, primarily by reaction with ozone. It is expected to exist solely in the particulate phase in an ambient atmosphere. Particulatephase diethylstilbestrol may be removed from the air by wet and dry deposition.

Diethylstilbestrol Preparation Products And Raw materials

Raw materials

Preparation Products

Diethylstilbestrol Suppliers

Global( 291)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
02783214688 CHINA 567 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Hebei shuoxi biotechnology co. LTD
whatsapp:+8613081092107 CHINA 973 58
86-18523575427 CHINA 47496 58

View Lastest Price from Diethylstilbestrol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Diethylstilbestrol
US $100.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-20 Diethylstilbestrol
US $5.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
2021-10-20 Diethylstilbestrol

Diethylstilbestrol Spectrum

56-53-1(Diethylstilbestrol)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved