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Diethylstilbestrol structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Diethylstilbestrol Properties

Melting point:
170-172 °C(lit.)
Boiling point:
351.51°C (rough estimate)
1.1096 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
methanol: 0.1 g/mL, clear, faintly yellow
pKa 9.02(H2O t=25 I=0.025) (Uncertain)
Crystalline Powder
White to almost white
Water Solubility 
Isomerizes rapidly in Benzene, Chloroform, and Ether. Keep Shielded from light.
CAS DataBase Reference
56-53-1(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Phenol, 4,4'-[(1E)-1,2-diethyl- 1,2-ethenediyl]bis-(56-53-1)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H315-H319-H335-H350-H360-H410
Precautionary statements  P201-P280-P305+P351+P338-P308+P313-P261-P273-P501
Hazard Codes  T,N
Risk Statements  45-61-36/37/38-51/53-40
Safety Statements  53-36/37/39-45-60-61-36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  WJ5600000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29072990

Diethylstilbestrol price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46207 Diethylstilbestrol VETRANAL , analytical standard 56-53-1 250mg $39.9 2018-11-13 Buy
Sigma-Aldrich 1195001 Diethylstilbestrol United States Pharmacopeia (USP) Reference Standard 56-53-1 200mg $348 2018-11-13 Buy
Cayman Chemical 10006876 Diethylstilbestrol ≥98% 56-53-1 5g $90 2018-11-19 Buy
Cayman Chemical 10006876 Diethylstilbestrol ≥98% 56-53-1 1g $20 2018-11-19 Buy
Sigma-Aldrich D4628 Diethylstilbestrol ≥99% (HPLC) 56-53-1 10g $506 2018-11-13 Buy

Diethylstilbestrol Chemical Properties,Uses,Production

Chemical Properties

White Solid


A synthetic, nonsteroidal estrogen. Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.

brand name

Stilbestrol (Tablicaps); Stilbetin (Bristol-Myers Squibb);Distilbene;Oestro-gynedron;Stilphostrol.

World Health Organization (WHO)

Diethylstilbestrol, a synthetic estrogen which is a stilbene derivative, was introduced into obstetric practice in the late 1940s and subsequently widely used for the treatment of threatened abortion. This use was later shown to be associated with an increased risk of vaginal cancer in the offspring which resulted in restrictive regulatory action in several countries. Diethylstilbestrol and other stilbenes remain available in many countries, however, for the treatment of certain hormone-dependent neoplasms including carcinoma of the prostate and postmenopausal breast cancer. (Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977)

General Description

At first glance, it might be surprising that synthetic nonsteroidal molecules such as diethylstilbestrol (DES) could have the same activity as estradiol or other estrogens. DES can be viewed, however, as a form of estradiol with rings B and C open and a six-carbon ring D. The activity of DES analogs was explained in 1946. It was proposed that the distance between the two DES phenol OH groups was the same as the 3-OH to 17-OH distance of estradiol; therefore, they could both fit the same receptor. Medicinal chemists have shown the OH-to-OH distance to be actually 12.1 ? in DES and 10.9 ? in estradiol. In aqueous solution, however, estradiol has two water molecules that are hydrogen bonded to the 17-OH. If one of the two water molecules is included in the distance measurement, there is a perfect fit with the two OH groups of DES. This suggests that water may have an important role for estradiol in its receptor site.
It is now generally accepted that the estrogens must have a phenolic moiety for binding, but some investigators propose that the receptor may be flexible enough to accommodate varying distances between the two key hydroxyls. This point about estrogens needing a phenolic ring for high-affinity binding to the ER is critical. Steroids with a phenolic A ring and related phenolic compounds lack high-affinity binding to the other steroid hormone receptors.

General Description

Odorless tasteless white crystalline powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Diethylstilbestrol is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .

Fire Hazard

Flash point data for Diethylstilbestrol are not available; however, Diethylstilbestrol is probably combustible.

Safety Profile

Confirmed carcinogen producing skin, liver, and lung tumors in exposed humans as well as uterine and other reproductive system tumors in the female offspring of exposed women. Experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. A human teratogen by many routes. Poison by intraperitoneal and subcutaneous routes. It causes glandular system effects by sktn contact. Human reproductive effects by ingestion: abnormalspermatogenesis; changes in testes, epididymis, and sperm duct; menstrual cycle changes or disorders; changes in female ferulity; unspecified maternal effects; developmental abnormalities of the fetal urogenital system; germ cell effects in offspring; and delayed effects in newborn. Implicated in male impotence and enlargement of male breasts. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also ETHINYL ESTRADIOL.


Diethylstilbestrol is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.


Environmental Protection Agency (EPA)
Comprehensive Environmental Response, Compensation, and Liability Act Reportable quantity (RQ) = 1 lb.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of diethylstilbestrol = U089. Listed as a hazardous constituent of waste.
Food and Drug Administration (FDA)
All oral and parenteral drug products containing greater than 25 mg per unit dose of diethylstilbestrol were removed from the market because they were found to be unsafe or not effective, and they may not be compounded.
Diethylstilbestrol is prohibited from extralabel use in food-producing animals.

Diethylstilbestrol Preparation Products And Raw materials

Raw materials

Preparation Products

Diethylstilbestrol Suppliers

Global( 209)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21726 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 535 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 892 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 30002 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28236 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23049 58

View Lastest Price from Diethylstilbestrol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-10 Diethylstilbestrol
US $1.00 / g 1g 98% 10kg career henan chemical co

Diethylstilbestrol Spectrum

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