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Quercetin

Expectorants Pharmacological effects Chemical Properties Uses Production method
Quercetin
Quercetin
CAS No.
117-39-5
Chemical Name:
Quercetin
Synonyms
MELETIN;natural;QUERTINE;Sophretin;QUERCETOL;QUERCITIN;QUERCETIN;kvercetin;Sophorefin;Sophorecin
CBNumber:
CB3230765
Molecular Formula:
C15H10O7
Formula Weight:
302.24
MOL File:
117-39-5.mol

Quercetin Properties

Melting point:
314-317°C
Boiling point:
363.28°C (rough estimate)
Density 
1.3616 (rough estimate)
refractive index 
1.4790 (estimate)
storage temp. 
Store at 0-5°C
form 
solid
Water Solubility 
<0.1 g/100 mL at 21 ºC
Merck 
13,8122
BRN 
317313
InChIKey
REFJWTPEDVJJIY-UHFFFAOYSA-N
CAS DataBase Reference
117-39-5(CAS DataBase Reference)
EPA Substance Registry System
4H-1-Benzopyran- 4-one, 2-(3,4-dihydroxyphenyl)-3, 5,7-trihydroxy-(117-39-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xi
Risk Statements  25-36/37/38
Safety Statements  45-36-26
RIDADR  2811
WGK Germany  3
RTECS  LK8750000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29329990
Hazardous Substances Data 117-39-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:

Quercetin price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Q4951 Quercetin ≥95% (HPLC), solid 117-39-5 10g $41.7 2018-11-13 Buy
Sigma-Aldrich Q4951 Quercetin ≥95% (HPLC), solid 117-39-5 100g $214 2018-11-13 Buy
Cayman Chemical 10005169 Quercetin ≥95% 117-39-5 5g $12 2018-11-19 Buy
Cayman Chemical 10005169 Quercetin ≥95% 117-39-5 10g $23 2018-11-19 Buy
Cayman Chemical 10005169 Quercetin ≥95% 117-39-5 50g $96 2018-11-19 Buy

Quercetin Chemical Properties,Uses,Production

Expectorants

Quercetin is commonly used as a expectorant drug in clinical medicine in China. This product has various kinds of pharmacological functions such as having a good expectorant, cough effect, also having certain anti-asthma effect, and having further effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, reducing blood fat, expansion of coronary artery, increasing coronary blood flow.
Clinically, quercetin is mainly used for treating clinical bronchitis and phlegmatic inflammation. It also has adjuvant therapy effect on coronary artery disease and high blood pressure. FDA may have some kinds of adverse reactions such as dry mouth, dizziness, and burning sensation in stomach area which may disappear after treatment.
Quercetin is widely distributed in angiosperms such as Threevein Astere, Golden Saxifrage, berchemia lineata, gold, rhododendron dauricum, seguin loquat, purple rhododendron, Rhododendron micranthum, Japanese Ardisia Herb and Apocynum. It is a kind of aglycon which mainly combines with carbohydrate to be in the form of glycosides, such as quercetin, rutin, hyperoside.

Pharmacological effects

Quercetin can significantly inhibit the effect of cancer-promoting agent, inhibiting the growth of malignant cells in vitro, inhibiting the DNA, RNA, and protein synthesis of Ehrlich ascites tumor cells.
Quercetin has effects of inhibiting the platelet aggregation and the release effect of serotonin (5-HT) as well as inhibiting the platelet aggregation process which is induced by ADP, thrombin and platelet-activating factor (PAF) in which having the strongest inhibition effect on PAF. Moreover, it can also inhibit thrombin-induced the release of platelet 3H-5-HT of rabbit.
(1) Intravenously adding 0.5mmol/L quercetin (10ml/kg) drop wise can significantly shorten the duration of arrhythmia in mice of myocardial ischemia and reperfusion, reduce the incidence of ventricular fibrillation, and reduce the content of MDA as well as the activity of xanthine oxidase inside the ischemic myocardial tissue while having significantly protective effect on SOD. This may be related to the inhibition of the formation process of myocardial oxygen free radical and protection of SOD or directly scavenging of radical free oxygen in myocardial tissue.
(2) Having in vitro assay with quercetin and rutin being together can disperse the platelet and thrombus adhered to the rabbit aorta endothelium with an EC50 of 80 and 500nmol/L, respectivly. In vitro assay of a concentration of quercetin at 50~500μmol/L has shown that it can improve cAMP level inside human platelet, enhance the PGI2-induced improvement of cAMP level of human platelet and inhibit the ADP-induced platelet aggregation. Quercetin at a concentration ranged from 2~50μmol/L has a concentration-dependent enhancement effect. Quercetin, at a concentration of 300 μmol/L in vitro can not only almost completely inhibit the process of platelet aggregation induced by platelet-activating factor (PAF), but also inhibit thrombin and ADP-induced platelet aggregation as well as inhibit the release of rabbit platelet 3H-5HT induced by thrombin; A concentration of 30 μmol/L can significantly reduce the liquidity of platelet membrane.
(3) Quercetin, at a concentration at 4×10-5~1×10-1g/ml, has a inhibitory effect on the release of histamine and SRS-A in the lung of ovalbumin-sensitized guinea pig lung; A concentration of 1 × 10-5g/ml also has inhibitory effect on the for SRS-A induced ileum contraction of guinea pig. Quercetin, at a concentration of 5~50μmol/L, has a concentration-dependent inhibitory effect on the process of histamine release of human basophilic leucocyte. Its inhibitory effect on the ileum contraction of ovalbumin sensitized guinea pig is also concentration-dependent with an IC50 of 10μmol/L. A concentration in the range of 5×10-6~5×10-5mol L can inhibit the proliferation of cytotoxic T lymphocyte (CTL) as well as inhibit ConA-induced DNA synthesis.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Chemical Properties

It is yellow needle-like crystalline powder. It has good thermal stability with the decomposition temperature being 314 °C. It can improve the light-tolerance property of food pigment for preventing the change of the flavor of food. Its color will change in case of metal ion. It is slightly soluble in water, soluble in an alkaline aqueous solution. Quercetin and its derivatives is a kind of flavonoid compound which are widely present in a variety of vegetables and fruits such as onions, sea buckthorn, hawthorn, locust, tea. It has effects of anti-free radical, anti-oxidation, anti-bacterial, anti-viral as well as anti-allergic. For application in lard, its various antioxidant indicators are similar with that of BHA or PG.
Because of the double bond between the 2,3 position as well as the two hydroxyl groups in 3 ', 4' , it has application of being used as a metal chelate or being the receptor of the free groups produced during the oxidation process of grease. In this case, it can be used as the antioxidants of ascorbic acid or grease. It also has a diuretic effect.

Uses

1. It can be used as a kind of antioxidant which is mainly used for oil, drinks, cold drinks, meat processing products.
2. It has good effects of expectorant, anti-cough, anti-asthma and can be used for treating chronic bronchitis as well as for adjuvant therapy of coronary heart disease and high blood pressure.
3. It can also be used as analytical standards

Production method

1. Crash the bark of trees in Fagaceae Quercus (Quercus) into powder, wash with hot brine, extract with dilute ammonia before neutralization with dilute sulfuric acid. Boil the filtrate and separate crystals.
2. It can be obtained by extracting Liliaceae onion (Alliumcepa) with 95% ethanol; it can also be produced from rutin (rutin) extract, quercetin, isoquercitrin, fennel glycosides, hyperoside, quercimeritrin, bloom glycosides through rutin degrading enzyme or hydrolysis with acidic aqueous solution.

Chemical Properties

Yellow to green yellow crystalline powde

Uses

Medicine, reported formation of epoxy resins on mixing with epichlorohydrin.

General Description

Yellow needles or yellow powder. Converts to anhydrous form at 203-207°F. Alcoholic solutions taste very bitter.

Air & Water Reactions

Sensitive to exposure to air and light. Insoluble in water.

Reactivity Profile

3,3',4',5,7-Pentahydroxyflavone is a strong antioxidant and a metal chelator. Promotes the formation of nitrosamines .

Hazard

Questionable carcinogen.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 3,3',4',5,7-Pentahydroxyflavone emits acrid smoke and irritating fumes.

Fire Hazard

Flash point data for 3,3',4',5,7-Pentahydroxyflavone are not available; however, 3,3',4',5,7-Pentahydroxyflavone is probably combustible.

Biological Activity

Anti-tumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A 2 , phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca 2+ and K + channels and behaves as an agonist at estrogen (GPR30) receptors.

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Human mutation data reported. Used as a pharmaceutical and veterinary drug. When heated to decomposition it emits acrid smoke and irritating fumes

Quercetin Preparation Products And Raw materials

Raw materials

Preparation Products


Quercetin Suppliers

Global( 268)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 893 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1583 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2200 58
Kono Chem Co., Ltd
+86-132 8924 6953
info@konochemical.com CHINA 2164 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3624 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Shaanxi Huike Botanical Development Co., Ltd +86-29-62663046;+86-18706899381
+86-29-82606529 market@huikes.com China 61 62

View Lastest Price from Quercetin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 Quercetin
117-39-5
US $1000.00 / KG 25KG 99% 10tons career henan chemical co

Quercetin Spectrum


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