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ChemicalBook >> CAS DataBase List >>(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Structure
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride structure
CAS No.
72795-01-8
Chemical Name:
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
Synonyms
CS-769;ICI 118;551 hydrochloride;CI 118551 Hydrochloride;ICI 118,551 hydrochloride, >=98%;(2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1);(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride;ICI118551,ICI 118,551 hydrochloride,ICI 118551,Adrenergic Receptor,ICI-118551,Inhibitor,Beta Receptor,inhibit,ICI 118,551
CBNumber:
CB32518939
Molecular Formula:
C17H28ClNO2
Molecular Weight:
313.87
MDL Number:
MOL File:
72795-01-8.mol
Last updated:2023-09-20 16:43:00
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(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Properties

storage temp. desiccated
solubility DMSO : 25 mg/mL (79.65 mM; Need ultrasonic)H2O : 12.5 mg/mL (39.83 mM; Need ultrasonic)
form powder
color white
FDA UNII 9GT820DINA

SAFETY

Risk and Safety Statements

WGK Germany  3

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I127 ICI 118,551 hydrochloride ≥98% (HPLC), powder 72795-01-8 5mg $263 2024-03-01 Buy
Sigma-Aldrich I127 ICI 118,551 hydrochloride ≥98% (HPLC), powder 72795-01-8 25mg $934 2024-03-01 Buy
Cayman Chemical 15591 ICI 118551 (hydrochloride) ≥99% 72795-01-8 10mg $145 2024-03-01 Buy
Cayman Chemical 15591 ICI 118551 (hydrochloride) ≥99% 72795-01-8 50mg $616 2024-03-01 Buy
TRC I163850 ICI 118,551 hydrochloride 72795-01-8 5mg $140 2021-12-16 Buy
Product number Packaging Price Buy
I127 5mg $263 Buy
I127 25mg $934 Buy
15591 10mg $145 Buy
15591 50mg $616 Buy
I163850 5mg $140 Buy

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Chemical Properties,Uses,Production

Description

ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.

Uses

The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.

Uses

ICI 118,551 hydrochloride has been used:

  • to block β-adrenergic signaling in various experiments
  • to counteract degradation by endogenous T-lymphocyte monoamine oxidases
  • to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

storage

Store at RT

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Suppliers

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Supplier Advantage
TargetMol Chemicals Inc. 		58
Alfa Chemistry 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Spectrum

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride(72795-01-8)1HNMR

72795-01-8((±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride)Related Search:

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GUANFACINE HCL

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ICI 118,551 hydrochloride, >=98% (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride (2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1) CS-769 CI 118551 Hydrochloride 551 hydrochloride ICI 118 ICI118551,ICI 118,551 hydrochloride,ICI 118551,Adrenergic Receptor,ICI-118551,Inhibitor,Beta Receptor,inhibit,ICI 118,551 72795-01-8 Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals