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Riluzole

Description References
Riluzole
Riluzole
CAS No.
1744-22-5
Chemical Name:
Riluzole
Synonyms
BF-37;RILUTEK;RILUZOLE;RP-54274;PK 26124;Rilutek (TN);Prestwick-03A08;Riluzole(Rilutek);BUTTPARK 13\02-09;Riluzole (200 mg)
CBNumber:
CB3353226
Molecular Formula:
C8H5F3N2OS
Formula Weight:
234.2
MOL File:
1744-22-5.mol
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Riluzole Properties

Melting point:
116-118°C
storage temp. 
Store at RT
solubility 
DMSO: ≥25 mg/mL
form 
solid
color 
white
Merck 
14,8223
InChIKey
FTALBRSUTCGOEG-UHFFFAOYSA-N
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xi
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DL2830000
Hazard Note  Irritant
HazardClass  IRRITANT
HazardClass  6.1
PackingGroup  II
HS Code  29342000
Toxicity LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Riluzole price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 557324 Riluzole 1744-22-5 50mg $119 2018-11-20 Buy
Sigma-Aldrich 1604337 Riluzole United States Pharmacopeia (USP) Reference Standard 1744-22-5 200mg $423.85 2018-11-13 Buy
TCI Chemical A2423 2-Amino-6-(trifluoromethoxy)benzothiazole >98.0%(HPLC)(T) 1744-22-5 5g $62 2018-11-22 Buy
TCI Chemical A2423 2-Amino-6-(trifluoromethoxy)benzothiazole >98.0%(HPLC)(T) 1744-22-5 25g $214 2018-11-22 Buy
Alfa Aesar H61328 2-Amino-6-(trifluoromethoxy)benzothiazole, 98% 1744-22-5 5g $80.4 2018-11-13 Buy

Riluzole Chemical Properties,Uses,Production

Description

Riluzole belongs to the derivative of benzothiazole with neuroprotective, potential anti-depressant and anxiolytic activities, which is used in the treatment of a certain type of nerve disease called amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease). It is effective to delay the onset of ventilator-dependence or tracheostomy in selected patients, slow down the deterioration of this disease and probably prolong survival by approximately two to three months. Besides, studies have proved that riluzole has anti-depressant activity for refractory depression and serves as an anxiolytic in the treatment of obsessive-compulsive disorder and generalized anxiety disorder.
However, riluzole does not cure the ALS and reverse nerve damage or muscle weakness. It is believed to function as an inhibitor of a natural substance called glutamate. It helps protect the nerves in the brain and spinal cord from too much of glutamate which may contribute to the nerve damage. Riluzole is available in both tablet and liquid form. The liquid formulation may be more suitable for patients with swallowing difficulties.

References

https://en.wikipedia.org/wiki/Riluzole
http://www.medicinenet.com/riluzole_oral_tablets/article.htm
https://pubchem.ncbi.nlm.nih.gov/compound/5070#section=Top

Chemical Properties

White Crystalline Solid

Uses

A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

Uses

anticonvulsant, glutamate release inhibitor, anti-ALS

Uses

Labeled Riluzole, intended for use as an internal standard for the quantification of Riluzole by GC- or LC-mass spectrometry.

Uses

A neuroprotective agent. A glutamate release inhibitor. An anticonvulsant

brand name

Rilutek (Sanofi Aventis).

Biological Activity

Novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Riluzole is able to act as a glutamate release inhibitor, blocks voltage-dependent Na + channels and inhibits GABA uptake by striatal synaptosomes.

Riluzole Preparation Products And Raw materials

Raw materials

4-(Trifluoromethoxy)aniline

Preparation Products

Riluzole Suppliers

Global( 211)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86 (0)571-855 867 18
 +86 (0)571-858 647 95 sales@capotchem.com China 19958 60
Beijing Cooperate Pharmaceutical Co.,Ltd. 		+86-10-60279497 +86(0)15646567669
 +86-10-60279497 sales01@cooperate-pharm.com CHINA 1531 55
ATK CHEMICAL COMPANY LIMITED 		+86 21 5161 9050/ 5187 7795
 +86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 14297 60
career henan chemical co 		+86-371-86658258
 sales@coreychem.com CHINA 20000 58
Target molecule Corp. 857-239-0968
 857-239-8801 service1@targetmol.com United States 2566 60
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
 +86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
 +86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
 86-21-50328109 3bsc@sina.com China 15940 69
Arden pharmaceutical &chemical Co., Ltd +86-(0)533-3595900 13793319233
 +86-(0)533-3595900 info@chems.com.cn China 670 61
Chembest Research Laboratories Limited +86(0)21-20908456
 +86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6058 61

View Lastest Price from Riluzole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-15 Riluzole
1744-22-5 		US $1.00 / KG 1G 98% 100KG career henan chemical co

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