Epirubicin hydrochloride

Epirubicin hydrochloride Properties

Melting point	185°C dec.
alpha	D20 +274° (c = 0.01 in methanol)
RTECS	QI9295750
Flash point	443.8℃
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO to 100mM, or in ethanol to 10mM
form	powder
color	red to deep red
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey	MWWSFMDVAYGXBV-UAOJCOQHSA-N
SMILES	C12=C(O)C3=C(C(=O)C4=C(C3=O)C=CC=C4OC)C(O)=C1[C@@]([H])(O[C@H]1O[C@@H](C)[C@H](O)[C@@H](N)C1)C[C@](O)(C(=O)CO)C2.Cl
NCI Dictionary of Cancer Terms	Ellence; epirubicin hydrochloride
FDA UNII	22966TX7J5
NCI Drug Dictionary	Ellence

Pharmacokinetic data

Protein binding	77%
Excreted unchanged in urine	9-10%
Volume of distribution	14-38
Biological half-life	30-40 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H340-H350-H360

Precautionary statements

P201-P301+P312+P330-P308+P313

Hazard Codes

Xn

Risk Statements

22-63-62-46-40

Safety Statements

36/37/38-45-46

WGK Germany

3

HS Code

29419090

NFPA 704

	0
2		0

Epirubicin hydrochloride price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E9406	Epirubicin hydrochloride ≥90% (HPLC)	56390-09-1	5mg	$217	2024-03-01	Buy
Sigma-Aldrich	BP992	Epirubicin hydrochloride British Pharmacopoeia (BP) Reference Standard	56390-09-1	100MG	$208	2024-03-01	Buy
Sigma-Aldrich	1237382	Epirubicin hydrochloride United States Pharmacopeia (USP) Reference Standard	56390-09-1	200mg	$1340	2024-03-01	Buy
Alfa Aesar	J60411	Epirubicin hydrochloride	56390-09-1	10mg	$244	2024-03-01	Buy
Alfa Aesar	J60411	Epirubicin hydrochloride	56390-09-1	100mg	$944	2024-03-01	Buy

Product number	Packaging	Price	Buy
E9406	5mg	$217	Buy
BP992	100MG	$208	Buy
1237382	200mg	$1340	Buy
J60411	10mg	$244	Buy
J60411	100mg	$944	Buy

Epirubicin hydrochloride Chemical Properties,Uses,Production

Description

Epirubicin hydrochloride is an antitumor antibiotic which is epimeric with doxorubicin a t the 4’-position of the amino sugar moiety. It has shown utility in the treatment of mammary, gastric, colorectal, pulmonary and ovarian carcinomas, as well as malignant lymphoma and melanoma and soft tissue sarcoma. It is reported to be less sardiotoxic than doxorubicin.

Description

Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin. Compared to doxorubicin, epirubicin is equally cytotoxic to HeLa cells (ID₅₀s = 9 μM). When used either alone or in combination therapies, epirubicin has been shown to demonstrate high rates of complete or partial remission in various cancers including advanced ovary, lymphomas, breast, pancreas, gastric, hepatocellular carcinoma, head and neck tumors, and colorectal.

Chemical Properties

Orange-Red Crystalline Solid

Originator

Erbamont (Italy)

Uses

Cell-permeable anthracycline anti-tumor antibiotic

Uses

Used as an antineoplastic

brand name

Ellence(Pfizer);FARMORUBICIN.

Biological Functions

This stereoisomer of doxorubicin has the 4′-hydroxy group of the daunosamine sugar oriented in the β-position . Epirubicin will be slowly reduced to the active C13 alcohol (epirubicinol), giving it a 30- to 38-hour half life, which is similar to that of doxorubicin. Unlike doxorubicinol, however, which was equally active with doxorubicin, epirubicinol has only one-tenth the activity of its parent drug and is not believed to contribute significantly to the therapeutic action of this agent.

Biological Activity

Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC 50 = 62.7 μ M in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.

Clinical Use

Epirubicin is indicated for use in breast cancer, and the starting dose is 100 to 120 mg/m2 (compared to a starting dose of 60–75 mg/m2 for doxorubicin).

Side effects

The side effects and precautions are as outlined previously for doxorubicin, although there is a lower risk of serious myocardial toxicity or myelotoxicity.

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: avoid with clozapine - increased risk of agranulocytosis.
Ciclosporin: increased risk of neurotoxicity
Cytotoxics: possible increased risk of cardiotoxicity with trastuzumab - avoid for up to 28 weeks after stopping trastuzumab.
Ulcer-healing drugs: concentration increased by cimetidine.
Vaccines: avoid with live vaccines

Metabolism

Cleavage of the epimerized sugar will occur before excretion, generating an aglycone that is indistinguishable from that generated by doxorubicin. Although excretion is primarily biliary, dosage reduction in severe renal impairment, as well as in hepatic dysfunction, is warranted.

storage

+4°C

References

1) Cersosimo?et al. (1986),?Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue; J. Clin. Oncol.,?4?425 2) Spadari?et al. (1986),?DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs; Anticancer Res.,?6?935 3) Minotti?et al. (2004),?Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity; Pharmacol. Rev.,?56?185 4) Mercuro?et al. (2007),?Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers; Oncologist,?12?1124

Epirubicin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Epirubicin hydrochloride Suppliers

Global( 412)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Kangcang new material Technology Co., LTD	+8619133911216	fanfan@kangcang.com.cn	China	340	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58

Supplier	Advantage
Hebei Kangcang new material Technology Co., LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from Epirubicin hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	Epirubicin hydrochloride 56390-09-1	US $20.00-10.00 / kg	1kg	98%	20	Hebei Kangcang new material Technology Co., LTD
2024-04-26	Epirubicin hydrochloride 56390-09-1	US $9.00-60.00 / g	10g	min99%	10 tons	Hebei Kangcang new material Technology Co., LTD
2023-07-04	Epirubicin hydrochloride 56390-09-1	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Epirubicin hydrochloride
56390-09-1
US $20.00-10.00 / kg
98%
Hebei Kangcang new material Technology Co., LTD

Epirubicin hydrochloride
56390-09-1
US $9.00-60.00 / g
min99%
Hebei Kangcang new material Technology Co., LTD

Epirubicin hydrochloride
56390-09-1
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Epirubicin hydrochloride Spectrum

Epirubicin hydrochloride(56390-09-1)¹HNMR

56390-09-1(Epirubicin hydrochloride)Related Search:

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Aminopyrine Centchroman Tetrahydro-4H-pyran-4-one ALTRENOGEST Glucosamine

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4’-epi-adriamycinhydrochloride 5,12-naphthacenedione,10-((3-amino-2,3,6-trideoxy-alpha-l-arabino-hexopyranosy 8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-l)oxy)-hyd EPIRUBICIN HYDROCHLORIDE EP STANDARD EpirubicinHc,LEp5, Adrial (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, hydrochloride (1:1) 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)- (8S,10S)-10-(((2S,4S,5R,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-tri Ellence, Farmorubicin, Pharmorubicin 5,12-Naphthacenedione, 10-(3-amino-2,3,6-trideoxy-.alpha.-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- Epidoxorubicin hydrochloride (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride Epirubicin hydrochloride Farmorubicin-RTU Epirubicin hydrochloride(4'-Epidoxorubicin) Ellence Epirubicin, Hydrochloride Salt Epirubicin Hydrochloride (200 mg) (8S-cis)-4'-Epidoxorubicin Hydrochloride Epirubicin HCl API (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedionehydrochloride Epirubin HCI Epirubicin hydrochloride, >=99% Epirubicin HCl Epirubicin hydrochloride (8s-cis)-rochlorid Epirubicin hydrochloride CRS (8S,10S)-10-(((2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride Epirubicin hydrochloride USP/EP/BP cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Epirubicin hydrochloride / Epirubicin hcl (8R,10S)-10-{[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-7-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione Epirubicin HydrochlorideQ: What is Epirubicin Hydrochloride Q: What is the CAS Number of Epirubicin Hydrochloride Q: What is the storage condition of Epirubicin Hydrochloride Q: What are the applications of Epirubicin Hydrochloride 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)- Epirubicin Hydrochloride (EPR.HCl), 97% Epirubicin Hydrochloride (1237382) CS-1396 Epirubicin hydrochloride, ≥90% (HPLC) Epirubicin Hydrochloride - CAS 56390-09-1 - Calbiochem epi-Doxorubicin HCl Epirubicin HCl (4'-epidoxorubicin) ELLENCE; PHARMORUBICIN; EPIRUBICIN EBEWE Epirubicin Ebewe (8S,10S)-10-(((2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride (Doxorubicin Impurity) Ebewe Epirubicin (IMI 28) HCl 56390-09-1 C27H28NO11xHCl C27H34ClNO11 C27H33NO11 57998 Anti-cancer&immunity API Antineoplastic Intermediates & Fine Chemicals Pharmaceuticals