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6-Aminocaproic acid

Chemical Name:
6-Aminocaproic acid
6-AMINOHEXANOIC ACID;ACS;Aminocaproic;6-aminohexanoate;EACA;Amicar;H-ACP-OH;Hepin;177 J.D;aminocaproic acid,EACA
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2024-06-17 11:00:44

6-Aminocaproic acid Properties

Melting point 207-209 °C (dec.) (lit.)
Boiling point 242.49°C (rough estimate)
Density 1.042 g/cm3
vapor pressure <0.1 hPa (20 °C)
refractive index 1.4870 (estimate)
Flash point 207-209°C
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL
form powder
pka 4.373(at 25℃)
color white
Odor Odorless
PH 7.0-7.5 (50g/l, H2O, 20℃)
Water Solubility SOLUBLE
Merck 14,432
BRN 906872
LogP 0.027 (est)
CAS DataBase Reference 60-32-2(CAS DataBase Reference)
EWG's Food Scores 1-3
FDA UNII U6F3787206
NCI Drug Dictionary Amicar
ATC code B02AA01
NIST Chemistry Reference Hexanoic acid, 6-amino-(60-32-2)
EPA Substance Registry System Hexanoic acid, 6-amino- (60-32-2)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H320-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  MO6300000
HS Code  29224995
Toxicity LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)
NFPA 704
2 0

6-Aminocaproic acid price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.00145 6-Aminohexanoic acid for synthesis 60-32-2 5G $33.6 2024-03-01 Buy
Sigma-Aldrich 8.00145 6-Aminohexanoic acid for synthesis 60-32-2 250g $77.7 2024-03-01 Buy
Sigma-Aldrich 8.00145 6-Aminohexanoic acid for synthesis 60-32-2 1kg $280 2024-03-01 Buy
Sigma-Aldrich 8.00145 6-Aminohexanoic acid for synthesis 60-32-2 5kg $966 2024-03-01 Buy
Sigma-Aldrich 07260 6-Aminohexanoic acid ≥98.5% (NT) 60-32-2 100g $146 2024-03-01 Buy
Product number Packaging Price Buy
8.00145 5G $33.6 Buy
8.00145 250g $77.7 Buy
8.00145 1kg $280 Buy
8.00145 5kg $966 Buy
07260 100g $146 Buy

6-Aminocaproic acid Chemical Properties,Uses,Production


6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease.


Chemical Properties

white crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform.


Epsilon,Roche,W. Germany,1962


EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.


6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.


ChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion.


6-aminocaproic acid is obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide.


6-Aminohexanoic acid was used as a biochemical reagent. It is also used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology.
6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect.

Manufacturing Process

5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired.

brand name

Amicar (Xanodyne).

Therapeutic Function


General Description

6-Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. It also is a protease inhibitor that displays anticancer activity but is limited by cytotoxicity.

Biochem/physiol Actions

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Mechanism of action

Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.

Safety Profile

Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.


Aminocaproic acid (24.4.1) is synthesized by hydrolyzing |? -caprolactam at high temperature.


Veterinary Drugs and Treatments

Aminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.

Synthesis of 6-Aminocaproic acid from Caprolactam
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View Lastest Price from 6-Aminocaproic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Aminocaproic acid pictures 2024-06-18 6-Aminocaproic acid
US $0.00 / KG 25KG 99 2mt Yancheng Green Chemicals Co.,Ltd
6-Aminocaproic acid pictures 2024-06-17 6-Aminocaproic acid
US $0.00-0.00 / kg 1kg 99% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
6-Aminocaproic acid pictures 2024-04-24 6-Aminocaproic acid
US $0.00-0.00 / KG 1KG 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
177 J.D. 177j.d. 177jd 6-amino-hexanoicaci Acepramin Acepramine Afibrin Amikar Aminokapron Atsemin Caplamin Capracid capralense Capramol Capranol Caprocid Caprolisin CL 10304 cl10304 CY 116 cy116 eacakabi EACS e-aminocaproicacid Epsamon Epsicapron Epsikapron Epsilcapramin epsilon S epsilon-Amino-n-hexanoic acid EPSILON-AMINO HEXANOIC ACID EPSILON-AMINO-N-CAPROIC ACID H-E-ACP-OH H-EPSILON-ACP-OH H-EPSILON-AHX-OH H-EPSILON-AMINOCAPROIC ACID H-AHX(6)-OH H-6-AHX-OH H-ACP(6)-OH NH2-(CH2)5-COOH OMEGA-AMINOCAPROIC ACID ETA-AMINOCAPROIC ACID 6-AMINOCAPROIC ACID SIGMAULTRA 6-Aminohexanoic acid 1 M Solution 6-AminocaproicAcid,>99% H-6-Aca-OH~epsilon-Aminocaproic acid~6-Aminohexanoic acid~EACA H-EAhx-OH 6-AMinocaproic acid, 99+% 500GR AMinocaproic-d6 Acidd6 A 14719 Acikaprin NSC 212532 NSC 400230 ε-AMino-n-hexanoic Acid 6-AMINOHEXANOIC ACID FOR SYNTHESIS AMinocaproic acid (AMicar) 6-AMinocaporic Acid Additive Screening Solution 32/Fluka kit no 78374