ChemicalBook >> CAS DataBase List >>Difluoroethane


Chemical Name:
F152A;R152A;R 152a;FC-152A;CH3CHF2;FKW152a;HFA152a;HFC-152A;dymel152;Fron152a
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2023-05-25

Difluoroethane Properties

Melting point -117 °C
Boiling point -25 °C
Density 0.966
vapor density 2.28 (vs air)
refractive index 1.2434
solubility Soluble 1 in 357 parts of water at 25°C.
Water Solubility 5.37g/L(0 ºC)
LogP 0.750
Indirect Additives used in Food Contact Substances 1,1-DIFLUOROETHANE
FDA 21 CFR 178.3010; 701.30
CAS DataBase Reference 75-37-6(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference Ethane, 1,1-difluoro-(75-37-6)
EPA Substance Registry System HFC-152a (75-37-6)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H220-H280
Precautionary statements  P210-P377-P381-P410+P403
Hazard Codes  F,F+
Risk Statements  11-12
Safety Statements  16-33-36-38
RIDADR  UN 1030 2.1
WGK Germany  1
RTECS  KI1410000
Hazard Note  Flammable
DOT Classification 2.1 (Flammable gas)
HazardClass  2.1
HS Code  2903392500
Toxicity LC50 inhalation in mouse: 977gm/m3/2H
NFPA 704
1 0

Difluoroethane Chemical Properties,Uses,Production

Chemical Properties

liquefied colourless gas under pressure

Chemical Properties

Difluoroethane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. Difluoroethane is noncorrosive and nonirritating.


HFC 152a is a specialty liquified hydrofluorocarbon gas. It is used as an intermediate in the production of fluorinated polymers, as an aerosol propellant in some specialty applications, and as a component in some refrigerant blends.

Production Methods

Difluoroethane is prepared from ethyne by the addition of hydrogen fluoride in the presence of a suitable catalyst. The difluoroethane formed is purified to remove all traces of water, as well as traces of the starting materials.

General Description

Difluoroethane is colorless, odorless gas shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbite. Difluoroethane is easily ignited. Its vapors are heavier than air and a flame can travel back to the source of leak very easily. This leak can be either a liquid or vapor leak. Difluoroethane can asphyxiate by the displacement of air. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.

Air & Water Reactions

Highly flammable.

Reactivity Profile

Halogenated aliphatic compounds, such as Difluoroethane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. The reaction of aluminum with various halogenated hydrocarbons produces a self-sustaining reaction with sufficient heat to melt aluminum pieces, examples of other halogenated hydrocarbons are fluorotrichloromethane, dichlorodifluoromethane, chlorodifluoromethane, tetrafluoromethane. The vigor of the reaction appears to be dependent on the combined degree of fluorination and the vapor pressure, [Chem. Eng. News 39(27):44(1961)].

Health Hazard

Inhalation of concentrated gas will cause suffocation. Contact with liquid can damage eyes because of low temperature. Frostbite may result from contact with liquid.

Pharmaceutical Applications

Difluoroethane, a hydrofluorocarbon (HFC), is an aerosol propellant used in topical pharmaceutical formulations. Difluoroethane may be used as a vehicle for dispersions and emulsions.
Since difluoroethane does not contain chlorine, there are no environmental controls on the use of this material as a propellant, since it does not deplete the ozone layer and is not a greenhouse gas.

Safety Profile

Mildly toxic by inhalation. Mutation data reported. Narcotic in high concentration. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. See also FLUORIDES.


Difluoroethane may be used as an aerosol propellant in topical pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritant material.
Deliberate inhalation of excessive quantities of this propellant may result in death, and the following ‘warning’ statements must appear on the label of all aerosols:
WARNING: Avoid inhalation. Keep away from eyes or other mucous membranes.
WARNING: Do not inhale directly; deliberate inhalation of contents can cause death.
WARNING: Use only as directed; intentional misuse by deliberately concentrating and inhaling the contents can be harmful or fatal.
WARNING: Do not inhale directly; deliberate inhalation of contents can cause death.or
WARNING: Use only as directed; intentional misuse by deliberately concentrating and inhaling the contents can be harmful or fatal.
WARNING: Contents under pressure. Do not puncture or incinerate container. Do not expose to heat or store at room temperature above 120°F (49°C). Keep out of the reach of children.
When propellants are used in topical aerosols they may cause a chilling effect on the skin, although this effect has been somewhat overcome by the use of vapor-tap valves. The propellants quickly vaporizefromtheskin,andarenonirritating whenusedasdirected.


Difluoroethane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place.


Compatible with the usual ingredients used in the formulation of pharmaceutical aerosols.

Regulatory Status

Accepted in the USA, by the FDA, for use as a topical aerosol propellant.

1,1-DIFLUOROETHANE ETHYLIDENE DIFLUORIDE ETHYLIDENE FLUORIDE DIFLUOROETHANE HFC-152A FC-152A freon 152a 1,1-Difluorethan 1,1-difluoro-ethan Algofrene Type 67 Algofrene67 algofrenetype67 CH3CHF2 Dymel 152 dymel152 dymel152a ethane,1,1-difluoro- ethylenefluoride F152A FKW152a fluorocarbon152a Freon 152 Freon-152 Fron152a GENETRON 100 Genetron 152a genetron100 genetron152a Halocarbon 152A halocarbon152a HCFC152a HCFC-152a HFA152a KαltemittelR152a Propellant 152a R 152a R152A refrigerant152a HYDROFLUOROCARBON 152A Chromist(TM) aerosol propellant 1,1-DIFLUOROETHANE, 98+% ETHYLIDENE FLUORIDE 99% ETHYLIDENE DIFLUORIDE 99% 1.1 Difluoroemethane 1,1-Difluoroethane(FC-152a)99% 1,1-Difluoroethane (Freon 152a) HCF-152A CFC-152A DIFLUOROETHANE HFC-152A 1,1-two fluoroethane 1,1-Difluoroethane ,99% Difluoroethane ISO 9001:2015 REACH Norflurane EP Impurity E 1,1-difluoroethane (HFC 152a [75-37-6]) 75-37-6 75376 CHF2CH3 Gelman