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Difluoroethane structure
Chemical Name:
F152A;R152A;R 152a;FC-152A;CH3CHF2;FKW152a;HFA152a;HFC-152A;dymel152;Fron152a
Molecular Formula:
Formula Weight:
MOL File:

Difluoroethane Properties

Melting point:
-117 °C
Boiling point:
-25 °C
vapor density 
2.28 (vs air)
refractive index 
Soluble 1 in 357 parts of water at 25°C.
Water Solubility 
5.37g/L(0 ºC)
Indirect Additives used in Food Contact Substances
178.3010; 701.30
CAS DataBase Reference
75-37-6(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Ethane, 1,1-difluoro-(75-37-6)
EPA Substance Registry System
HFC-152a (75-37-6)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H220-H280
Precautionary statements  P210-P377-P381-P410+P403
Hazard Codes  F,F+
Risk Statements  11-12
Safety Statements  16-33-36-38
RIDADR  UN 1030 2.1
WGK Germany  1
RTECS  KI1410000
Hazard Note  Flammable
DOT Classification 2.1 (Flammable gas)
HazardClass  2.1
Toxicity LC50 inhalation in mouse: 977gm/m3/2H
NFPA 704
1 0

Difluoroethane Chemical Properties,Uses,Production

Chemical Properties

liquefied colourless gas under pressure

Chemical Properties

Difluoroethane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. Difluoroethane is noncorrosive and nonirritating.


HFC 152a is a specialty liquified hydrofluorocarbon gas. It is used as an intermediate in the production of fluorinated polymers, as an aerosol propellant in some specialty applications, and as a component in some refrigerant blends.

Production Methods

Difluoroethane is prepared from ethyne by the addition of hydrogen fluoride in the presence of a suitable catalyst. The difluoroethane formed is purified to remove all traces of water, as well as traces of the starting materials.

General Description

Difluoroethane is colorless, odorless gas shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbite. Difluoroethane is easily ignited. Its vapors are heavier than air and a flame can travel back to the source of leak very easily. This leak can be either a liquid or vapor leak. Difluoroethane can asphyxiate by the displacement of air. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.

Air & Water Reactions

Highly flammable.

Reactivity Profile

Halogenated aliphatic compounds, such as Difluoroethane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. The reaction of aluminum with various halogenated hydrocarbons produces a self-sustaining reaction with sufficient heat to melt aluminum pieces, examples of other halogenated hydrocarbons are fluorotrichloromethane, dichlorodifluoromethane, chlorodifluoromethane, tetrafluoromethane. The vigor of the reaction appears to be dependent on the combined degree of fluorination and the vapor pressure, [Chem. Eng. News 39(27):44(1961)].

Health Hazard

Inhalation of concentrated gas will cause suffocation. Contact with liquid can damage eyes because of low temperature. Frostbite may result from contact with liquid.

Pharmaceutical Applications

Difluoroethane, a hydrofluorocarbon (HFC), is an aerosol propellant used in topical pharmaceutical formulations. Difluoroethane may be used as a vehicle for dispersions and emulsions.
Since difluoroethane does not contain chlorine, there are no environmental controls on the use of this material as a propellant, since it does not deplete the ozone layer and is not a greenhouse gas.

Safety Profile

Mildly toxic by inhalation. Mutation data reported. Narcotic in high concentration. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. See also FLUORIDES.


Difluoroethane may be used as an aerosol propellant in topical pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritant material.
Deliberate inhalation of excessive quantities of this propellant may result in death, and the following ‘warning’ statements must appear on the label of all aerosols:
WARNING: Avoid inhalation. Keep away from eyes or other mucous membranes.
WARNING: Do not inhale directly; deliberate inhalation of contents can cause death.
WARNING: Use only as directed; intentional misuse by deliberately concentrating and inhaling the contents can be harmful or fatal.
WARNING: Do not inhale directly; deliberate inhalation of contents can cause death.or
WARNING: Use only as directed; intentional misuse by deliberately concentrating and inhaling the contents can be harmful or fatal.
WARNING: Contents under pressure. Do not puncture or incinerate container. Do not expose to heat or store at room temperature above 120°F (49°C). Keep out of the reach of children.
When propellants are used in topical aerosols they may cause a chilling effect on the skin, although this effect has been somewhat overcome by the use of vapor-tap valves. The propellants quickly vaporizefromtheskin,andarenonirritating whenusedasdirected.


Difluoroethane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place.


Compatible with the usual ingredients used in the formulation of pharmaceutical aerosols.

Regulatory Status

Accepted in the USA, by the FDA, for use as a topical aerosol propellant.

Difluoroethane Preparation Products And Raw materials

Raw materials

Preparation Products

Difluoroethane Suppliers

Global( 94)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20012 60
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6369 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
86-18523575427 CHINA 47498 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 CHINA 29864 58
13806087780 +86 13806087780 CHINA 17606 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 CHINA 9938 58
Yangzhou Model Electronic Materials Co., Ltd.
+8613761402923 CHINA 440 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 CHINA 32439 55

View Lastest Price from Difluoroethane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-25 Difluoroethane
US $0.10 / KG 1KG 95%-99% 1kg; 50kg; 500kg Career Henan Chemical Co

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