Forodesine
- CAS No.
- 209799-67-7
- Chemical Name:
- Forodesine
- Synonyms
- Fodosine;Forodesine;Isopamphos;Immucillin-H;BCX-1777 freebase;FORODESINE FODOSINE;(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride;(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H;4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
- CBNumber:
- CB41120376
- Molecular Formula:
- C11H14N4O4
- Molecular Weight:
- 266.25
- MDL Number:
- MFCD09837827
- MOL File:
- 209799-67-7.mol
Boiling point | 613.5±65.0 °C(Predicted) |
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Density | 2.01 |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
solubility | PBS (pH 7.2): 5 mg/ml |
form | A crystalline solid |
pka | 13.88±0.70(Predicted) |
color | Light brown to gray |
FDA UNII | 426X066ELK |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
NFPA 704 |
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Forodesine price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 30475 | Forodesine | 209799-67-7 | 1mg | $36 | 2023-06-20 | Buy |
Cayman Chemical | 30475 | Forodesine | 209799-67-7 | 25mg | $308 | 2023-06-20 | Buy |
Cayman Chemical | 30475 | Forodesine | 209799-67-7 | 5mg | $159 | 2023-06-20 | Buy |
Cayman Chemical | 30475 | Forodesine | 209799-67-7 | 10mg | $194 | 2023-06-20 | Buy |
TRC | F754540 | Fodosine | 209799-67-7 | 1mg | $55 | 2021-12-16 | Buy |
Forodesine Chemical Properties,Uses,Production
Description
Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).
Uses
Fodosine is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic.
Uses
Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.
Definition
ChEBI: Immucillin H is a pyrrolopyrimidine and a dihydroxypyrrolidine.
Forodesine Preparation Products And Raw materials
Raw materials
Preparation Products
Forodesine Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9316 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9980 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39010 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 |
View Lastest Price from Forodesine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-13 | Forodesine
209799-67-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-09 | Forodesine
209799-67-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Forodesine
209799-67-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Forodesine
209799-67-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd