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Povidone iodine

Topical disinfectants Physical and Chemical Properties Pharmacodynamics Indications Side effects Precautions Uses
Povidone iodine
Povidone iodine structure
CAS No.
25655-41-8
Chemical Name:
Povidone iodine
Synonyms
I-PVP;pvp-1;PVP-I;videne;disphex;inadine;isodine;braunol;efo-dine;betadine
CBNumber:
CB1121625
Molecular Formula:
C8H15NO
Formula Weight:
141.2108
MOL File:
25655-41-8.mol

Povidone iodine Properties

Melting point:
300 °C
solubility 
H2O: soluble100mg/mL
form 
Powder
color 
Yellow-brown
Water Solubility 
Soluble in water, ethyl alcohol, isopropyl alcohol, polyethylene glycol and glycerol. Insoluble in chloroform, carbon tetrachloride, hexane, acetone and petroleum ether.
Merck 
13,7784
InChIKey
FAAHNQAYWKTLFD-UHFFFAOYSA-N
FDA 21 CFR
310.545
CAS DataBase Reference
25655-41-8(CAS DataBase Reference)
EWG's Food Scores
1-3
FDA UNII
85H0HZU99M
EPA Substance Registry System
Povidone-iodine (25655-41-8)
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25-22
WGK Germany  2
RTECS  TR1579600
TSCA  Yes
HS Code  29339900

Povidone iodine price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PVP1 Poly(vinylpyrrolidone)–Iodine complex 25655-41-8 100g $107 2019-12-02 Buy
Sigma-Aldrich PVP1 Poly(vinylpyrrolidone)–Iodine complex 25655-41-8 1kg $741 2019-12-02 Buy
Alfa Aesar 045782 Polyvinylpyrrolidone-iodine complex 25655-41-8 50g $39.3 2020-06-24 Buy
Alfa Aesar 045782 Polyvinylpyrrolidone-iodine complex 25655-41-8 1kg $536 2020-06-24 Buy
Sigma-Aldrich Y0000466 Povidone (iodinated) European Pharmacopoeia (EP) Reference Standard 25655-41-8 y0000466 $183 2019-12-02 Buy

Povidone iodine Chemical Properties,Uses,Production

Topical disinfectants

Povidone iodine is an unstable complex formed from the complexation of iodine with a surfactant, belonging to a type of topical iodine disinfectant. At room temperature, it is yellow-brown to red-brown amorphous powder which is soluble in water or ethanol but insoluble in ether or chloroform. Thevinyl-2-pyrrolidone homopolymer inside it is a kind of surfactants which can facilitate the wetting and penetration of solution on the object, thereby enhancing the sterilization effect of iodine. Of which 80 to 90% of the binding iodine can be depolymerization into free iodine with a large the concentration and a strong bactericidal capability. It is tasteless, non-irritating, non-allergenic, and of low toxicity. It is a kind of broad-spectrum fungicide which can kill viruses, bacteria, spores, fungi, and protozoa. At a concentration of 15ppm, within 1 minute, it can kill various kinds of bacteria (Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) propagules; it takes a relative long time for it to kill Mycobacterium tuberculosis; killing fungi (B. subtilis) takes 1.5 hours; killing black variant of Bacillus cereus and Bacillus requires higher concentrations and longer time; at a concentration of 150ppm, within 10 minutes, it can destroy the hepatitis B surface antigen (HBsAg). In addition to be applied for the skin disinfection, this product can also be used for disinfecting of metallic medical equipment, utensils and the like. It is usually read or amber in the concentration for disinfection which can not only be directly applied to the skin or meninges of the surgical incision site of a patient, but also used for the in vitro flushing purposes in obstetrics and urology. When its concentration is reduced to below 10ppm, it turns white or pale yellow and loses bactericidal activity.

Physical and Chemical Properties

Povidone iodine is a loose complex formed through the association of elemental iodine with polymer carrier with povidone playing a role of carrier and facilitating solubilization. At room temperature, it is yellow-brown to red-brown amorphous powder. It is slightly odor, easily soluble in water or alcohol with its aqueous solution being acidic; it is also insoluble in ether, chloroform, acetone, ethane and carbon tetrachloride.
The aqueous solution of povidone iodine has no disadvantages of iodine tincture with a light color and being easy to subject to washing. It has a small irritating effect on mucous membrane, and no alcohol deiodination, and free of corrosion effect and has a low toxicity.
The molecular structure of povidone-iodine
Figure 1: The molecular structure of povidone-iodine.

Pharmacodynamics

Povidone iodine is a kind of iodine disinfectant which directly cause in vivo protein denaturation, precipitation of bacteria, and further resulting in the death of pathogenic microorganisms. Therefore, it is effective in disinfection and sterilization. It can kill viruses, bacteria, spores, fungi, and protozoa with low toxicity to human. Povidone-iodine aqueous solution has strong pharmacological activity against Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, syphilis, hepatitis B virus, HIV, and Trichomonas vaginalis.
Povidone iodine gel is a gynecological topical semi-mobile colloidal agent made by povidone iodine and hydrophilic matrix. It is a system for maintaining its sustained release. Owing to the continuous release of free iodine, it can enable the skin and mucous membranes to maintain a certain effective concentration of iodine for killing bacteria. It is mainly used for gynecological vaginal infection. It exerted its effect through being miscible with vaginal secretions and further killing the inside pathogenic microorganisms, and thus blocking the spread of sexually transmitted diseases and invasion, as well as treating other infected vaginal diseases caused by other kinds of bacteria.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Indications

The major indications of Povidone iodine are as follows:
1. it can be used for treating suppurative dermatitis, fungal skin infection, and small area of ​​mild burns; can also be used for disinfection of small area of ​​skin and mucous membrane wound.
2.It can be used for the prevention and tropic disinfection of various kinds of diseases such as bacterial and mould vaginitis, cervical erosion, trichomonas vaginitis, genital itching, smelly genital infection, yellow and smelly leucorrhea, comprehensive genital inflammation, elderly vaginitis, herpes, gonorrhea, syphilis and genital warts.
3. It can be used for treating glans inflammation, posthitis, and the disinfection of genitalia and the surrounding area. Also used for the prevention and tropical treatment and disinfection of gonorrhea, syphilis, and genital warts.
4.it can be applied to the disinfection of cutlery and tableware.
5. it can be used or the disinfection surgical area of skin.

Side effects

It can cause allergic reactions and irritation on the skin and mucous membrane, but is relatively mild compared with the stimulus of iodine. Adverse reactions are rare. But external use for pregnant and lactating women and infants can lead to obvious absorption of iodine which can cause common reactions such as local irritation and burning feeling. Large-scale and long-term application can occasionally cause neutropenia syndrome with severe burning cases can cause metabolic acidosis, liver damage, and contact dermatitis, hypothyroidism and iodine poisoning.

Precautions

1. Patients being allergic to this good or iodine should be disabled.
2. For patients of non-toxic gum-like thyroid tumor or with burning area higher than 20%, big open wounds, patients treated with lithium and patients with thyroid disease are not recommended for local application or long-term application. Patients of liver dysfunction or burning injury are not recommended to apply. Pregnant women and children (especially newborns) should apply with caution.
3. During the application of povidone iodine, the following physiological parameters should be monitored: protein binding efficiency, renal function, and the electrolyte content. For newborns infant, T4 and TSH need to be measured every 7 to 10 days.

Uses

1. It has bactericidal effect like iodine. It can be used as disinfectant and bacteriostatic agent in the medicine for anti-septic purposes for eye drops, nasal drops, and cream agents. It can also be made into disinfectant.
2. It is mainly used for the skin disinfection and equipment disinfection in hospital surgery and injections as well as prevention of infection in the field of stomatology, gynecology, surgery, and dermatology; it can also be used for disinfection of household utensils and appliances; for food industry and aquaculture industry, it is used for disinfection and animal disease control. It is the preferred international and domestic choice of medical iodine-contained fungicides and disinfectants for epidemic prevention.
3. It is a kind of iodine carrier, the so-called “tamed iodine”. Because this product can gradually release iodine to exert an antibacterial effect; its mechanism of action is through causing the protein denaturation and further death of bacteria. It is effective in treating bacteria, fungi, as well as viruses with a relative small tissue irritation effect.

Description

Povidone-iodine is an iodophor. A 10% povidoneiodine solution contains 1% available iodine, but free iodine is at a concentration of 0.001%. Occupational exposure can cause irritant rather than allergie contact dermatitis in healtheare workers.

Chemical Properties

yellowish to reddish-brown powder

Uses

Topical anti-infective

Uses

PVP-I is a broad spectrum antiseptic for topical application. It is used in first aid for minor cuts, grazes, burns, abrasions and blisters. PVP-I has broad applications in medicine as a surgical scrub; for pre- and post-operative skin cleansing; for the

brand name

Betadine (Alcon); E-Z Prep (Becton Dickinson Microbiology).

Contact allergens

Povidone-iodine is iodophor, used as a topical antiseptic. A 10% povidone-iodine solution contains 1% available iodine, but free-iodine is at 0.1% concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation, however, iodine seems to be the true hapten.

Contact allergens

Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA? cream.

Veterinary Drugs and Treatments

An iodophore antiseptic, povidone iodine is rapidly bactericidal (against gram-positive and – negative bacteria) at low concentration. Also fungicidal and sporicidal (as a 1% aqueous solution). It is commonly used as a topical pre-surgical skin cleaner/antiseptic, but is infrequently used in small animal dermatology due to its drying, irritating and staining effects.
Povidone acts by slowly releasing iodine to tissues. Indicated for superficial pyoderma and Malassezia dermatitis.

Veterinary Drugs and Treatments

Dilute solutions of povidone iodine (1% – 5%) have been utilized for chemical debridement of loose epithelium in canine indolent ulcers. 5% povidone iodine has also been used as an antifungal for fungal keratitis, but must be lavaged from the eye within 5 minutes to prevent damage to corneal epithelium. Generally, povidone iodine is only used once daily and then rinsed off when used in the eye as an anti-fungal. There has also been a renewed interest in utilizing povidone iodine in treating feline herpes keratitis. Solutions of commercially available 10% povidone iodine are diluted in physiologic saline to concentrations of 0.5 – 1% and applied 1 drop twice to four times daily for treatment of chronic feline herpes keratitis and may also be used prophylactically for feline herpes-virus (FHV) cats with a history of recurring ulcer.

Povidone iodine Preparation Products And Raw materials

Raw materials

Preparation Products


Povidone iodine Suppliers

Global( 312)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2680 55
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10154 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21837 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hebei Chishuo Biotechnology Co., Ltd.
13292891350 +86 311 66567340
luna@speedgainpharma.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2581 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58

View Lastest Price from Povidone iodine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-06-11 Povidone iodine
25655-41-8
US $100.00 / Kg/Drum 100Kg/Drum 99% 20tons Haihang Industry Co.,Ltd
2020-05-03 Povidone iodine
25655-41-8
US $0.00-0.00 / KG 1KG 99.0% 600 Tons Shaanxi Dideu Medichem Co. Ltd
2019-12-27 Povidone iodine
25655-41-8
US $0.10-0.10 / KG 1KG 99% 10000KG Shaanxi Dideu Medichem Co. Ltd

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