OLIGOMYCIN C
- CAS No.
- 11052-72-5
- Chemical Name:
- OLIGOMYCIN C
- Synonyms
- OLIGOMYCIN C;Oligmycin C;12-Deoxyoligomycin A;Oligomycin A, 12-deoxy-;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
- CBNumber:
- CB4354053
- Molecular Formula:
- C45H74O10
- Molecular Weight:
- 775.06
- MDL Number:
- MFCD32182610
- MOL File:
- 11052-72-5.mol
- MSDS File:
- SDS
| Boiling point | 876.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.091 g/cm3 |
| storage temp. | −20°C |
| solubility | Soluble in DMSO |
| form | White to off-white powder. |
| pka | 13.49±0.70(Predicted) |
| Merck | 13,6902 |
| EWG's Food Scores | 1 |
| FDA UNII | 4F7MA81184 |
OLIGOMYCIN C price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19162 | Oligomycin C ≥95% | 11052-72-5 | 1mg | $323 | 2023-01-06 | Buy |
| Cayman Chemical | 19162 | Oligomycin C ≥95% | 11052-72-5 | 5mg | $969 | 2023-01-06 | Buy |
| TRC | O532985 | OligomycinC | 11052-72-5 | 1mg | $325 | 2021-12-16 | Buy |
| Usbiological | O6154-02 | Oligomycin C | 11052-72-5 | 1mg | $523 | 2021-12-16 | Buy |
| Apolloscientific | BIO1007 | Oligomycin C | 11052-72-5 | 1mg | $134 | 2021-12-16 | Buy |
OLIGOMYCIN C Chemical Properties,Uses,Production
Description
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.
Uses
Oligomycin C is an ATP synthetase and RVD inhibitor.
Uses
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors
References
[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.
OLIGOMYCIN C Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19650 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696 15000506266 | 2311958233@qq.com | China | 3522 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 | info@efebio.com | China | 9913 | 58 |
| Lynnchem | 029-85992781 17792393971 | info@lynnchem.com | China | 4465 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 8718 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | 400-+86-400-002-6226 +86-13028896684 | sales@rrkchem.com | China | 54669 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18717932730 | sales@chemegen.com | China | 11292 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
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