OSI-420
- CAS No.
- 183321-86-0
- Chemical Name:
- OSI-420
- Synonyms
- OSI-420;CP 373420;Erlotinib-10;OSI-420 impurity;β-Amyloid (1-42);ROSCOVITINE(CVC202);OSI-420 (free base);Erlotinib iMpurity H;Erlotinib impurity J;Erlotinib impurity N
- CBNumber:
- CB4501590
- Molecular Formula:
- C21H21N3O4
- Molecular Weight:
- 379.41
- MDL Number:
- MFCD09841129
- MOL File:
- 183321-86-0.mol
- MSDS File:
- SDS
| Melting point | 140-142°C |
|---|---|
| Density | 1.30 |
| storage temp. | -20°C Freezer |
| solubility | insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO |
| form | A crystalline solid |
| FDA UNII | X78J9Z28DQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
OSI-420 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23394 | Desmethyl Erlotinib ≥98% | 183321-86-0 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 23394 | Desmethyl Erlotinib ≥98% | 183321-86-0 | 5mg | $201 | 2024-03-01 | Buy |
| Cayman Chemical | 23394 | Desmethyl Erlotinib | 183321-86-0 | 10mg | $370 | 2024-03-01 | Buy |
| TRC | O702250 | OSI-420,FreeBase(DesmethylErlotinib) | 183321-86-0 | 1mg | $275 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FO26597 | Desmethyl erlotinib | 183321-86-0 | 5mg | $294 | 2021-12-16 | Buy |
OSI-420 Chemical Properties,Uses,Production
Description
Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.
Chemical Properties
Off-White Solid
Uses
A metabolite of Erlotinib (E625000), an anti cancer agent.
Uses
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
References
[1] zhang w1, siu ll, moore mj, chen ex.simultaneous determination of osi-774 and its major metabolite osi-420 in human plasma by using hplc with uv detection. j chromatogr b analyt technol biomed life sci. 2005 jan 5;814(1):143-7.
[2] bonomi p. erlotinib: a new therapeutic approach for non-small cell lung cancer.expert opin investig drugs. 2003 aug;12(8):1395-401.
OSI-420 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Payne Pharmaceutical Technology Co.Ltd | 021-58123769 18678586262 | info@paynepharm.com | China | 1354 | 58 |