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1-Adamantanamine hydrochloride

1-Adamantanamine hydrochloride
1-Adamantanamine hydrochloride structure
CAS No.
665-66-7
Chemical Name:
1-Adamantanamine hydrochloride
Synonyms
Adekin;virasol;Lysovir;exp105-1;nsc83653;Mantadan;Mantadix;Virofral;Amazolon;Midantan
CBNumber:
CB4734376
Molecular Formula:
C10H18ClN
Formula Weight:
187.71
MOL File:
665-66-7.mol

1-Adamantanamine hydrochloride Properties

Melting point:
>300 °C(lit.)
Boiling point:
308.63°C (rough estimate)
Density 
1.0276 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Store below +30°C.
solubility 
H2O: 50 mg/mL
form 
Fine Crystalline Powder
color 
White
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,374
BRN 
4198854
InChIKey
WOLHOYHSEKDWQH-UHFFFAOYSA-N
CAS DataBase Reference
665-66-7(CAS DataBase Reference)
FDA UNII
M6Q1EO9TD0
NCI Dictionary of Cancer Terms
amantadine hydrochloride
NCI Drug Dictionary
amantadine hydrochloride
Proposition 65 List
Amantadine Hydrochloride
EPA Substance Registry System
Amantadine hydrochloride (665-66-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H315-H319-H361-H302
Precautionary statements  P301+P312+P330-P201-P301+P312a-P308+P313-P405-P501a-P264-P270-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
Hazard Codes  Xn
Risk Statements  22-40-20/21/22
Safety Statements  22-36/37-36-35-20/21
RIDADR  UN 1759 8 / PGII
WGK Germany  3
RTECS  AU4375000
TSCA  Yes
HazardClass  IRRITANT
HS Code  29213000
Toxicity LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier)

1-Adamantanamine hydrochloride price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.20015 1-Adamantaneammonium chloride for synthesis 665-66-7 10 g $48.65 2021-03-22 Buy
Sigma-Aldrich A1260 Amantadine hydrochloride 665-66-7 5g $55.2 2021-03-22 Buy
Sigma-Aldrich 8.20015 1-Adamantaneammonium chloride for synthesis 665-66-7 50 g $178.52 2021-03-22 Buy
Sigma-Aldrich A0363000 Amantadine hydrochloride European Pharmacopoeia (EP) Reference Standard 665-66-7 $190 2021-03-22 Buy
Sigma-Aldrich BP530 Amantadine hydrochloride British Pharmacopoeia (BP) Reference Standard 665-66-7 $220 2021-03-22 Buy

1-Adamantanamine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Symmetrel,DuPont (Endo),US,1966

Uses

antiviral, antiparkinsonian; treatment of drug-induced extrapyrimidal reactions

Uses

selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as Latanoprost -20oC

Uses

NMDA-receptor antagonist. Antiviral; antiparkinsonian

Definition

ChEBI: A hydrochloride obtained by combining amantadine and hydrochloric acid in equimolar amounts.

Manufacturing Process

360 ml of 96% sulfuric acid and a solution of 13.6 grams (0.1 mol) of adamantane in 100 ml of n-hexane were emulsified in the apparatus described and provided with an inclined centrifugal stirrer. Then a mixture of 46 grams (1.7 mols) of liquid hydrocyanic acid and 29.6 grams (0.4 mol) of tertiary butanol was added dropwise within 1.5 hours at about 25°C.
After 30 minutes of postreaction, the product was poured on ice. The granular mass which precipitated [N-(adamantyl-1)formamide] was sucked off and washed with water. The raw product (37 grams) was then refluxed for 10 hours with a solution of 60 grams of NaOH in 600 ml of diethylene glycol.
After cooling, the solution was diluted with 1.5 liters of water and subjected to three extractions with ether. The amine was extracted from the ethereal solution with 2 N HCl and liberated therefrom by the addition of solid NaOH (while cooling). The alkaline solution was extracted with ether and the ethereal solution was dried with solid NaOH. Distillation resulted in 10.6 grams (70% of the theory) of 1-aminoadamantane which, after sublimation, melted at 180°C to 192°C (seal capillary). It is converted to the hydrochloride.

brand name

Symadine (Solvay Pharmaceuticals); Symmetrel (Endo).

Therapeutic Function

Antiviral, Antiparkinsonian

Safety Profile

Human poison by ingestion. Poison by ingestion, intraperitoneal, and intravenous routes. A human teratogen with developmental abnormalities of the circulatory system. Experimental reproductive effects. Human systemic effects by ingestion: distorted perceptions, euphoria, excitement, hallucinations. When heated to decomposition it emits very toxic fumes of NO, and HCl.

Purification Methods

Dissolve the salt in dry EtOH, add a few drops of dry EtOH saturated with HCl gas, followed by dry Et2O to crystallise the hydrochloride. Dry the salt in a vacuum. [Stetter et al. Chem Ber 93 226 1960.]

1-Adamantanamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


1-Adamantanamine hydrochloride Suppliers

Global( 447)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
NANJING SUNSHINE BIOTECH CO.,LTD
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+86-25-86189616 brian@sunshine-bio.com CHINA 128 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
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+86-21-37122233
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View Lastest Price from 1-Adamantanamine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-26 Amantadine Hydrochloride
665-66-7
US $10.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-08-18 amantadine hydrochloride
665-66-7
US $100.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-07-29 1-Adamantanamine hydrochloride
665-66-7
US $10.00 / KG 1KG 99% 1000MT/Month Wuhan wingroup Pharmaceutical Co., Ltd

1-Adamantanamine hydrochloride Spectrum


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