1-Adamantanamine hydrochloride
- CAS No.
- 665-66-7
- Chemical Name:
- 1-Adamantanamine hydrochloride
- Synonyms
- AMANTADINE HCL;AMANTADINE HYDROCHLORIDE;1-AMINOADAMANTANE HYDROCHLORIDE;symmetrel;1-ADAMANTANAMINE HCL;Mantadan;ADAMANTANAMINE HYDROCHLORIDE;Amantadine hydrochloride,1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride;Adekin;virasol
- CBNumber:
- CB4734376
- Molecular Formula:
- C10H18ClN
- Molecular Weight:
- 187.71
- MDL Number:
- MFCD00074723
- MOL File:
- 665-66-7.mol
- MSDS File:
- SDS
| Melting point | >300 °C(lit.) |
|---|---|
| Boiling point | 308.63°C (rough estimate) |
| Density | 1.0276 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | H2O: 50 mg/mL |
| form | Fine Crystalline Powder |
| color | White |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,374 |
| BRN | 4198854 |
| InChIKey | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
| LogP | -1.64 at 23℃ and pH6.3 |
| CAS DataBase Reference | 665-66-7(CAS DataBase Reference) |
| FDA UNII | M6Q1EO9TD0 |
| NCI Dictionary of Cancer Terms | amantadine hydrochloride |
| NCI Drug Dictionary | amantadine hydrochloride |
| Proposition 65 List | Amantadine Hydrochloride |
| EPA Substance Registry System | Amantadine hydrochloride (665-66-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-40-20/21/22 | |||||||||
| Safety Statements | 22-36/37-36-35-20/21 | |||||||||
| RIDADR | UN 1759 8 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU4375000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29213000 | |||||||||
| Toxicity | LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier) | |||||||||
| NFPA 704 |
|
1-Adamantanamine hydrochloride price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1260 | Amantadine hydrochloride | 665-66-7 | 5g | $65.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP530 | Amantadine hydrochloride British Pharmacopoeia (BP) Reference Standard | 665-66-7 | 200MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.20015 | 1-Adamantaneammonium chloride for synthesis | 665-66-7 | 10g | $66.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.20015 | 1-Adamantaneammonium chloride for synthesis | 665-66-7 | 50g | $241 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1018505 | Amantadine hydrochloride United States Pharmacopeia (USP) Reference Standard | 665-66-7 | 200mg | $436 | 2024-03-01 | Buy |
1-Adamantanamine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Originator
Symmetrel,DuPont (Endo),US,1966
Uses
selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as Latanoprost -20oC
Uses
antiviral, antiparkinsonian; treatment of drug-induced extrapyrimidal reactions
Uses
NMDA-receptor antagonist. Antiviral; antiparkinsonian
Uses
1-Adamantanamine hydrochloride is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extra pyramidal reactions, and for postherpetic neuralgia. It is also used an NMDA-receptor antagoinst.
Definition
ChEBI: A hydrochloride obtained by combining amantadine and hydrochloric acid in equimolar amounts.
Manufacturing Process
360 ml of 96% sulfuric acid and a solution of 13.6 grams (0.1 mol) of
adamantane in 100 ml of n-hexane were emulsified in the apparatus
described and provided with an inclined centrifugal stirrer. Then a mixture of
46 grams (1.7 mols) of liquid hydrocyanic acid and 29.6 grams (0.4 mol) of
tertiary butanol was added dropwise within 1.5 hours at about 25°C.
After 30 minutes of postreaction, the product was poured on ice. The granular
mass which precipitated [N-(adamantyl-1)formamide] was sucked off and
washed with water. The raw product (37 grams) was then refluxed for 10
hours with a solution of 60 grams of NaOH in 600 ml of diethylene glycol.
After cooling, the solution was diluted with 1.5 liters of water and subjected to
three extractions with ether. The amine was extracted from the ethereal
solution with 2 N HCl and liberated therefrom by the addition of solid NaOH
(while cooling). The alkaline solution was extracted with ether and the
ethereal solution was dried with solid NaOH. Distillation resulted in 10.6 grams
(70% of the theory) of 1-aminoadamantane which, after sublimation, melted
at 180°C to 192°C (seal capillary). It is converted to the hydrochloride.
brand name
Symadine (Solvay Pharmaceuticals); Symmetrel (Endo).
Therapeutic Function
Antiviral, Antiparkinsonian
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biological Activity
amantadine hydrochloride is an antiviral and an antiparkinsonian drug.
Biochem/physiol Actions
Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.
Clinical Use
Parkinson’s disease (but not drug-induced
extrapyramidal symptoms)
Post-herpetic neuralgia
Prophylaxis and treatment of influenza A
Safety Profile
Human poison by ingestion. Poison by ingestion, intraperitoneal, and intravenous routes. A human teratogen with developmental abnormalities of the circulatory system. Experimental reproductive effects. Human systemic effects by ingestion: distorted perceptions, euphoria, excitement, hallucinations. When heated to decomposition it emits very toxic fumes of NO, and HCl.
Drug interactions
Potentially hazardous interactions with other drugs
Memantine: increased risk of CNS toxicity - avoid;
effects of amantadine possibly enhanced.
Metabolism
Amantadine is metabolised in the liver to a minor extent, mainly by N-acetylation. The renal amantadine clearance is much higher than the creatinine clearance, suggesting renal tubular secretion in addition to glomerular filtration. After 4-5 days, 90% of the dose appears unchanged in urine. The rate is considerably influenced by urinary pH: a rise in pH brings about a fall in excretion.
storage
Room temperature
Purification Methods
Dissolve the salt in dry EtOH, add a few drops of dry EtOH saturated with HCl gas, followed by dry Et2O to crystallise the hydrochloride. Dry the salt in a vacuum. [Stetter et al. Chem Ber 93 226 1960.]
1-Adamantanamine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 | mw@qwpharmatech.com | China | 109 | 58 |
| Huzhou Chenxi Environmental Protection Technology Co. , Ltd. | +8616762203950 | 1034385273@qq.com | China | 27 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 893 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 298 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
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View Lastest Price from 1-Adamantanamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-11 | Amantadine HCl
665-66-7
|
US $0.00 / kg | 1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2024-04-07 | Adamantanamine hydrochloride
665-66-7
|
US $100.00 / kg | 1kg | 99% | 1t | Zibo Wei Bin Import & Export Trade Co. Ltd. | |
 |
2024-03-08 | Amantadine hydrochloride
665-66-7
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd |
-
- Amantadine HCl
665-66-7
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Adamantanamine hydrochloride
665-66-7
- US $100.00 / kg
- 99%
- Zibo Wei Bin Import & Export Trade Co. Ltd.
-
- Amantadine hydrochloride
665-66-7
- US $10.00 / kg
- 99%
- Nantong Guangyuan Chemicl Co,Ltd
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