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2,6-Dihydroxybenzaldehyde

2,6-Dihydroxybenzaldehyde Structure
2,6-Dihydroxybenzaldehyde structure
CAS No.
387-46-2
Chemical Name:
2,6-Dihydroxybenzaldehyde
Synonyms
2,6-DIHYDROXYBENZALDEHYDE;2,6-Dihydroxy Benzoldehyde;Benzaldehyde, 2,6-dihydroxy-;2,6-dihydroxybenzaldehyde(387-46-2)
CBNumber:
CB4747901
Molecular Formula:
C7H6O3
Molecular Weight:
138.12
MDL Number:
MFCD08061915
MOL File:
387-46-2.mol
Last updated:2025-12-01 18:33:23
Product description Number Pack Size Price
2,6-Dihydroxybenzaldehyde D451015 1g $125
2,6-Dihydroxybenzaldehyde D451015 2.5g $185
2,6-Dihydroxybenzaldehyde D451015 10g $520
2,6-Dihydroxybenzaldehyde 99.75% CS-W001105 1g $38
2,6-Dihydroxybenzaldehyde FD63326 1g $50
More product size
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2,6-Dihydroxybenzaldehyde Properties

Melting point 154-155°C
Boiling point 223°C
Density 1.409
Flash point 103°C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 7.66±0.10(Predicted)
color Pale Yellow to Light Yellow
Stability Hygroscopic
InChI InChI=1S/C7H6O3/c8-4-5-6(9)2-1-3-7(5)10/h1-4,9-10H
InChIKey DGXAGETVRDOQFP-UHFFFAOYSA-N
SMILES C(=O)C1=C(O)C=CC=C1O
FDA UNII K89FJ2AWV2

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H335-H315-H318
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310

2,6-Dihydroxybenzaldehyde price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D451015 2,6-Dihydroxybenzaldehyde 387-46-2 1g $125 2021-12-16 Buy
TRC D451015 2,6-Dihydroxybenzaldehyde 387-46-2 2.5g $185 2021-12-16 Buy
TRC D451015 2,6-Dihydroxybenzaldehyde 387-46-2 10g $520 2021-12-16 Buy
ChemScene CS-W001105 2,6-Dihydroxybenzaldehyde 99.75% 387-46-2 1g $38 2021-12-16 Buy
Biosynth Carbosynth FD63326 2,6-Dihydroxybenzaldehyde 387-46-2 1g $50 2021-12-16 Buy
Product number Packaging Price Buy
D451015 1g $125 Buy
D451015 2.5g $185 Buy
D451015 10g $520 Buy
CS-W001105 1g $38 Buy
FD63326 1g $50 Buy

2,6-Dihydroxybenzaldehyde Chemical Properties,Uses,Production

Uses

2,6-Dihydroxybenzaldehyde is a reactant used in the synthesis of cinnamides as potent cholinesterase inhibitors.

Definition

ChEBI: 2,6-dihydroxybenzaldehyde is a dihydroxybenzaldehyde.

Synthesis

2,6-Dimethoxybenzaldehyde

3392-97-0

2,6-Dihydroxybenzaldehyde

387-46-2

The general procedure for the synthesis of 2,6-dihydroxybenzaldehyde from 2,6-dimethoxybenzaldehyde was as follows: a dichloromethane (1200 mL) solution of AlCl3 (240 g, 1.80 mol, 3.00 eq.) was added to a 3000 mL three-necked round bottom flask. The reaction mixture was cooled to 0 °C, followed by the slow dropwise addition of a dichloromethane (800 mL) solution of 2,6-dimethoxybenzaldehyde (100 g, 601.78 mmol, 1.00 equiv). After the dropwise addition was completed, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction was quenched with 200 mL of dilute hydrochloric acid (2 M). The reaction mixture was extracted with dichloromethane (2 x 200 mL). The organic layers were combined and concentrated under vacuum. The concentrated residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:200 to 1:50) as eluent to give 40 g (48% yield) of 2,6-dihydroxybenzaldehyde as a yellow solid. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 11.25 (s, 2H), 10.25 (s, 1H), 7.36 (m, 1H), 6.36 (d, J = 8.4 Hz, 2H); mass spectrum (ESI) m/z 139 [M + H]+.

References

[1] Green Chemistry, 2018, vol. 20, # 4, p. 804 - 808
[2] Chemistry - A European Journal, 2009, vol. 15, # 1, p. 125 - 135
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 14, p. 6772 - 6790
[4] Patent: CN105566276, 2016, A. Location in patent: Paragraph 0130; 0134; 0135; 0136
[5] Helvetica Chimica Acta, 2005, vol. 88, # 1, p. 120 - 153

2,6-Dihydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

2,6-Dimethoxybenzaldehyde Dichloromethane Hydrochloric acid Aluminum chloride Water

Preparation Products

Voxelotor

2,6-Dihydroxybenzaldehyde Suppliers

Global( 198)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 4000 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hangzhou Milon Pharmatech Co.,Ltd. 		+8618083715844 sales02@milonpharm.com China 292 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		0431-80514535 13634302652 Extension@chemextension.com CHINA 967 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hangzhou Milon Pharmatech Co.,Ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from 2,6-Dihydroxybenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,6-Dihydroxybenzaldehyde pictures 2026-01-13 2,6-Dihydroxybenzaldehyde
387-46-2
 US $0.00-0.00 / kg 1kg 97.0%min；99.0%min 60KG/Batch Hangzhou Milon Pharmatech Co.,Ltd.
2,6-Dihydroxybenzaldehyde pictures 2025-12-01 2,6-Dihydroxybenzaldehyde
387-46-2
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2,6-Dihydroxybenzaldehyde pictures 2025-06-27 2,6-Dihydroxybenzaldehyde
387-46-2
 US $0.00 / KG 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd

2,6-Dihydroxybenzaldehyde Spectrum

2,6-Dihydroxybenzaldehyde(387-46-2)1HNMR

387-46-2(2,6-Dihydroxybenzaldehyde)Related Search:

Protocatechualdehyde 4-Hydroxybenzaldehyde 2,5-Dihydroxybenzaldehyde 3,5-Dihydroxybenzaldehyde 2,4-Dihydroxybenzaldehyde
2,3-Dihydroxybenzaldehyde Benzaldehyde Triclosan Salicylaldehyde 2,4,6-Trihydroxybenzoic acid
Apigenin 2,6-Dimethoxybenzoyl chloride Myricetin 2,6-Dihydroxybenzoic acid VISNAGIN
2',6'-Dihydroxyacetophenone 4,6-DIMETHOXYSALICYLALDEHYDE Phloretin

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2,6-DIHYDROXYBENZALDEHYDE Benzaldehyde, 2,6-dihydroxy- 2,6-dihydroxybenzaldehyde(387-46-2) 2,6-Dihydroxy Benzoldehyde 387-46-2 384-46-2 Aromatic Aldehydes & Derivatives (substituted)