Benfotiamine
- CAS No.
- 22457-89-2
- Chemical Name:
- Benfotiamine
- Synonyms
- btmp;S-BENZOYLTHIAMINE O-MONOPHOSPHATE;benzoylthiamineo-monophosphate;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];berdi;MilgaMMa;betivina;8088c.b.;biotamin;tabiomyl
- CBNumber:
- CB4775966
- Molecular Formula:
- C19H23N4O6PS
- Molecular Weight:
- 466.45
- MDL Number:
- MFCD00057343
- MOL File:
- 22457-89-2.mol
| Melting point | 165 C |
|---|---|
| Boiling point | 745.1±70.0 °C(Predicted) |
| Density | 1.444±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), DMSO (Heated, Sonicated) |
| form | Solid |
| pka | 1.84±0.10(Predicted) |
| color | White to Off-White |
| Merck | 14,1041 |
| InChIKey | BTNNPSLJPBRMLZ-GHRIWEEISA-N |
| CAS DataBase Reference | 22457-89-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | Y92OUS2H9B |
| ATC code | A11DA03 |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn |
|---|---|
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | DH6910000 |
Benfotiamine price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B9636 | S-Benzoylthiamine O-monophosphate | 22457-89-2 | 250mg | $66.4 | 2022-05-15 | Buy |
| TCI Chemical | B4711 | S-Benzoylthiamine O-Monophosphate >98.0%(HPLC)(T) | 22457-89-2 | 5g | $76 | 2022-04-27 | Buy |
| TCI Chemical | B4711 | S-Benzoylthiamine O-Monophosphate >98.0%(HPLC)(T) | 22457-89-2 | 25g | $192 | 2022-04-27 | Buy |
| Cayman Chemical | 22192 | Benfotiamine ≥98% | 22457-89-2 | 500mg | $39 | 2022-04-27 | Buy |
| Cayman Chemical | 22192 | Benfotiamine ≥98% | 22457-89-2 | 1g | $74 | 2022-04-27 | Buy |
Benfotiamine Chemical Properties,Uses,Production
Chemical Properties
crystals
Originator
Biotamin,Sankyo
Uses
Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).
Uses
Definition
ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Manufacturing Process
28.6 g 84% phosphoric acid was heated to temperature about 270°C. After
cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was
added and left at temperature 100°C before an isolation of HCl was ended.
After adding of an ice water and acetone, phosphate ester of vitamin B1 was
fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient
temperature 7 days for a hydrolysis. Then a solution was with acetone diluted
and the mixture was cooled, whereupon vitamin B1 monophosphate
hydrochloride was isolated.
The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts
of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was
dropwise added with stirring and cooling. The obtained mixture was
neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5-
4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was
precipitated. The product was suspended in water, was bringing with NaOH to
pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate
was prepared; MP: 165°C (with decomposition).
Therapeutic Function
Analgesic
General Description
Biochem/physiol Actions
S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.
Benfotiamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Royal Chemical Co., Ltd. | +86-25-86655873 +8613962173137 | marketing@royal-chem.com | China | 536 | 55 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 19994 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 22021 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | fandachem@gmail.com | China | 9383 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418679 | info@tnjchem.com | China | 2995 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29959 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | +8615562555968 | info@pharmachemm.com | China | 222 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 86-18871470254 | linda@hubeijusheng.com | CHINA | 28229 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 +86-19930503282 | alice@crovellbio.com | China | 5953 | 58 |
| Xiamen AmoyChem Co., Ltd | 592-6051114 | sales@amoychem.com | CHINA | 6369 | 58 |
View Lastest Price from Benfotiamine manufacturers
| Image | Release date | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-06-01 | Benfotiamine
22457-89-2
|
US $1.00 / mg | 1000mg | 99 | 5ton/month | ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD | |
 |
2022-05-11 | Benfotiamine
22457-89-2
|
US $0.00-0.00 / G | 1G | 99%HPLC | 100KG | Senova Technology Co. Ltd. | |
 |
2022-04-24 | Benfotiamine
22457-89-2
|
US $12.00 / kg | 1kg | 99 | 5000kg | Jiangsu Bangdeya New Material Technology Co.,Ltd |
-
- Benfotiamine
22457-89-2
- US $1.00 / mg
- 99
- ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
-
- Benfotiamine
22457-89-2
- US $0.00-0.00 / G
- 99%HPLC
- Senova Technology Co. Ltd.
-
- Benfotiamine
22457-89-2
- US $12.00 / kg
- 99
- Jiangsu Bangdeya New Material Technology Co.,Ltd
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