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Benfotiamine

CAS No.
22457-89-2
Chemical Name:
Benfotiamine
Synonyms
btmp;S-BENZOYLTHIAMINE O-MONOPHOSPHATE;benzoylthiamineo-monophosphate;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];berdi;MilgaMMa;betivina;8088c.b.;biotamin;tabiomyl
CBNumber:
CB4775966
Molecular Formula:
C19H23N4O6PS
Molecular Weight:
466.45
MDL Number:
MFCD00057343
MOL File:
22457-89-2.mol

Benfotiamine Properties

Melting point 165 C
Boiling point 745.1±70.0 °C(Predicted)
Density 1.444±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Aqueous Acid (Slightly), DMSO (Heated, Sonicated)
form Solid
pka 1.84±0.10(Predicted)
color White to Off-White
Merck 14,1041
InChIKey BTNNPSLJPBRMLZ-GHRIWEEISA-N
CAS DataBase Reference 22457-89-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII Y92OUS2H9B
ATC code A11DA03

SAFETY

Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  DH6910000

Benfotiamine price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B9636 S-Benzoylthiamine O-monophosphate 22457-89-2 250mg $66.4 2022-05-15 Buy
TCI Chemical B4711 S-Benzoylthiamine O-Monophosphate >98.0%(HPLC)(T) 22457-89-2 5g $76 2022-04-27 Buy
TCI Chemical B4711 S-Benzoylthiamine O-Monophosphate >98.0%(HPLC)(T) 22457-89-2 25g $192 2022-04-27 Buy
Cayman Chemical 22192 Benfotiamine ≥98% 22457-89-2 500mg $39 2022-04-27 Buy
Cayman Chemical 22192 Benfotiamine ≥98% 22457-89-2 1g $74 2022-04-27 Buy
Product number Packaging Price Buy
B9636 250mg $66.4 Buy
B4711 5g $76 Buy
B4711 25g $192 Buy
22192 500mg $39 Buy
22192 1g $74 Buy

Benfotiamine Chemical Properties,Uses,Production

Chemical Properties

crystals

Originator

Biotamin,Sankyo

Uses

Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).

Uses

S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.

Definition

ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.

Manufacturing Process

28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated.
The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).

Therapeutic Function

Analgesic

General Description

S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine?contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine.

Biochem/physiol Actions

S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.

Benfotiamine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 302)Suppliers
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View Lastest Price from Benfotiamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-06-01 Benfotiamine
22457-89-2
US $1.00 / mg 1000mg 99 5ton/month ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
2022-05-11 Benfotiamine
22457-89-2
US $0.00-0.00 / G 1G 99%HPLC 100KG Senova Technology Co. Ltd.
2022-04-24 Benfotiamine
22457-89-2
US $12.00 / kg 1kg 99 5000kg Jiangsu Bangdeya New Material Technology Co.,Ltd
  • Benfotiamine
    22457-89-2
  • US $1.00 / mg
  • 99
  • ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
  • Benfotiamine
    22457-89-2
  • US $0.00-0.00 / G
  • 99%HPLC
  • Senova Technology Co. Ltd.
  • Benfotiamine
    22457-89-2
  • US $12.00 / kg
  • 99
  • Jiangsu Bangdeya New Material Technology Co.,Ltd
berdi betivina benphothiamine BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE) S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-5-(phosphonooxy)-2-penten-3-yl] ester Benfotiamine {[(3E)-4-{N-[(4-aMino-2-MethylpyriMidin-5-yl)Methyl]forMaMido}-3-[(E)-benzoylsulfanyl]pent-3-en-1-yl]oxy}phosphonic acid Benzenecarbothioic Acid S-[2-[[(4-AMino-2-Methyl-5-pyriMidinyl)Methyl] forMylaMino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] Ester MilgaMMa S-BenzoylthiaMine O Benfotiamine (S-Benzoylthiamine O-Monophosphate) S-{(1Z)-2-[[(4-Amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino]-1-[2-(phosphonooxy)ethyl]-1-propenyl} benzenecarbothioate n-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide-s-benzoate dihydrogen phosphate (4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamidedihydrogenphosphate(ester 8088c.b. benzoylthiaminemonophosphate Benfotiamine, >=98% bietamine biotamin neurostop nitanevril s-benzoylthiaminemonophosphate s-esterwithn-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-benzoicaci tabiomyl thiaminemonophosphatebenzoyl vitanevril S-Benzoyl-thiamin-monophosphat Benfotiamine, BR [4-[(4-amino-2-methyl-5-pyrimidinyl)methyl-formylamino]-3-phenacylpent-3-enyl] dihydrogen phosphate S-Benzoylthiamine O-Monophosphate > Benfotiamine fandachem Nootropic Benfotiamine BenfotiamineQ: What is Benfotiamine Q: What is the CAS Number of Benfotiamine Q: What are the applications of Benfotiamine AtorvastatinQ: What is Atorvastatin Q: What is the CAS Number of Atorvastatin Q: What are the applications of Atorvastatin benzoylthiamineo-monophosphate Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] S-BENZOYLTHIAMINE O-MONOPHOSPHATE btmp 22457-89-2 C19H23N4O6PS API BIOTAMIN Pharmaceutical intermediate Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Phosphorylating and Phosphitylating Agents Sulfur & Selenium Compounds