ChemicalBook >> CAS DataBase List >>Benfotiamine


Chemical Name:
btmp;S-BENZOYLTHIAMINE O-MONOPHOSPHATE;benzoylthiamineo-monophosphate;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];berdi;MilgaMMa;betivina;8088c.b.;biotamin;tabiomyl
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:

Benfotiamine Properties

Melting point 165 C
Boiling point 745.1±70.0 °C(Predicted)
Density 1.444±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Aqueous Acid (Slightly), DMSO (Heated, Sonicated)
form Solid
pka 1.84±0.10(Predicted)
color White to Off-White
Merck 14,1041
CAS DataBase Reference 22457-89-2(CAS DataBase Reference)
EWG's Food Scores 1
ATC code A11DA03


Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  DH6910000

Benfotiamine price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B9636 S-Benzoylthiamine O-monophosphate 22457-89-2 250mg $66.4 2022-05-15 Buy
TCI Chemical B4711 S-Benzoylthiamine O-Monophosphate >98.0%(HPLC)(T) 22457-89-2 5g $76 2022-04-27 Buy
TCI Chemical B4711 S-Benzoylthiamine O-Monophosphate >98.0%(HPLC)(T) 22457-89-2 25g $192 2022-04-27 Buy
Cayman Chemical 22192 Benfotiamine ≥98% 22457-89-2 500mg $39 2022-04-27 Buy
Cayman Chemical 22192 Benfotiamine ≥98% 22457-89-2 1g $74 2022-04-27 Buy
Product number Packaging Price Buy
B9636 250mg $66.4 Buy
B4711 5g $76 Buy
B4711 25g $192 Buy
22192 500mg $39 Buy
22192 1g $74 Buy

Benfotiamine Chemical Properties,Uses,Production

Chemical Properties





Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).


S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.


ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.

Manufacturing Process

28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated.
The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).

Therapeutic Function


General Description

S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine?contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine.

Biochem/physiol Actions

S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.

Benfotiamine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 302)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Royal Chemical Co., Ltd.
+86-25-86655873 +8613962173137 China 536 55
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 19994 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 22021 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9383 55
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418679 China 2995 55
career henan chemical co
+86-0371-86658258 China 29959 58
Jinan Jianfeng Chemical Co., Ltd
+8615562555968 China 222 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254 CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 +86-19930503282 China 5953 58
Xiamen AmoyChem Co., Ltd
592-6051114 CHINA 6369 58

View Lastest Price from Benfotiamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-06-01 Benfotiamine
US $1.00 / mg 1000mg 99 5ton/month ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
2022-05-11 Benfotiamine
US $0.00-0.00 / G 1G 99%HPLC 100KG Senova Technology Co. Ltd.
2022-04-24 Benfotiamine
US $12.00 / kg 1kg 99 5000kg Jiangsu Bangdeya New Material Technology Co.,Ltd
  • Benfotiamine
  • US $1.00 / mg
  • 99
  • Benfotiamine
  • US $0.00-0.00 / G
  • 99%HPLC
  • Senova Technology Co. Ltd.
  • Benfotiamine
  • US $12.00 / kg
  • 99
  • Jiangsu Bangdeya New Material Technology Co.,Ltd
berdi betivina benphothiamine BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE) S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-5-(phosphonooxy)-2-penten-3-yl] ester Benfotiamine {[(3E)-4-{N-[(4-aMino-2-MethylpyriMidin-5-yl)Methyl]forMaMido}-3-[(E)-benzoylsulfanyl]pent-3-en-1-yl]oxy}phosphonic acid Benzenecarbothioic Acid S-[2-[[(4-AMino-2-Methyl-5-pyriMidinyl)Methyl] forMylaMino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] Ester MilgaMMa S-BenzoylthiaMine O Benfotiamine (S-Benzoylthiamine O-Monophosphate) S-{(1Z)-2-[[(4-Amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino]-1-[2-(phosphonooxy)ethyl]-1-propenyl} benzenecarbothioate n-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide-s-benzoate dihydrogen phosphate (4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamidedihydrogenphosphate(ester 8088c.b. benzoylthiaminemonophosphate Benfotiamine, >=98% bietamine biotamin neurostop nitanevril s-benzoylthiaminemonophosphate s-esterwithn-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-benzoicaci tabiomyl thiaminemonophosphatebenzoyl vitanevril S-Benzoyl-thiamin-monophosphat Benfotiamine, BR [4-[(4-amino-2-methyl-5-pyrimidinyl)methyl-formylamino]-3-phenacylpent-3-enyl] dihydrogen phosphate S-Benzoylthiamine O-Monophosphate > Benfotiamine fandachem Nootropic Benfotiamine BenfotiamineQ: What is Benfotiamine Q: What is the CAS Number of Benfotiamine Q: What are the applications of Benfotiamine AtorvastatinQ: What is Atorvastatin Q: What is the CAS Number of Atorvastatin Q: What are the applications of Atorvastatin benzoylthiamineo-monophosphate Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] S-BENZOYLTHIAMINE O-MONOPHOSPHATE btmp 22457-89-2 C19H23N4O6PS API BIOTAMIN Pharmaceutical intermediate Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Phosphorylating and Phosphitylating Agents Sulfur & Selenium Compounds