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Darunavir

AIDS treatment
Darunavir
Darunavir
CAS No.
206361-99-1
Chemical Name:
Darunavir
Synonyms
D03656;TMC-114;UIC-94017;Darunavir;Darunavir (usan/inn);Darunavir( UIC-94017,TMC-114);Darunaviroxy-1-phenylbutan-2-yl]carbamate;(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3;(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate;(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
CBNumber:
CB51176244
Molecular Formula:
C27H37N3O7S
Formula Weight:
547.66
MOL File:
206361-99-1.mol

Darunavir Properties

Melting point:
74-760C
storage temp. 
-20°C Freezer
form 
powder
color 
white to beige

SAFETY

WGK Germany  3

Darunavir price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15866 Darunavir ≥98% 206361-99-1 1mg $59 2018-11-13 Buy
Cayman Chemical 15866 Darunavir ≥98% 206361-99-1 5mg $162 2018-11-13 Buy
Cayman Chemical 15866 Darunavir ≥98% 206361-99-1 10mg $295 2018-11-13 Buy

Darunavir Chemical Properties,Uses,Production

AIDS treatment

Darunavir is a new kind of non peptide anti retroviral protease inhibitors in AIDS therapy. It is first developed by the Johnson pharmaceutical Iceland branch, Tibotec. It is of the highest bioavailability in the 6 protease inhibitors (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir and ABT378/r). It acts by blocking the formation of new and mature virus particles from the surface of the infected host cells and inhibiting the virus's protease. When the product is used for a long time, it usually can reduce the HIV virus vector in blood, increase the count of CD4 cells, reduce the chance of HIV infection, improve the quality of life and prolong life. It is suitable for adults who are infected with the HIV virus but have no effect on the use of existing antiretroviral drugs. The drug must be combined with the use of low doses of ritonavir or other antiretroviral agents, in order to improve the efficacy. The antiviral activity in vitro can be evaluated by being against acute and chronic infected lymphocytes and lymphocytes in peripheral blood. The IC50 is 0.012 to 0.08 mmol/ L for acute infected cells and 0.41 mmol/L for chronic infected cells. For oral administration, recommended dose is 1,200mg once and twice per day. The doseshould be reduced for patients with mild to moderate liver dysfunction and those with renal dysfunction. The adverse reaction of darunavir is mainly gastrointestinal reaction, flushing, itching and perioral numbness, depression, mood disorders, taste disorder etc. This product is not recommended for patients with moderate to severe liver dysfunction. Because of the sulfonamides in this component, it is prohibited for those who are allergic to sulfanilamide and any component in the prescription of this product.

Chemical Properties

White Amorphous Solid

Uses

Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral

Definition

ChEBI: An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.

Darunavir Preparation Products And Raw materials

Raw materials

Preparation Products


Darunavir Suppliers

Global( 125)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 1954 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22060 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Hubei widely chemical technology Co., Ltd. 027-83991130
027-83991130 1718093273@QQ.COM China 1021 58
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6058 61
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197
010-68882204 bjhkby@126.com China 100 61
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2930 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Alabiochem Tech.Co., Ltd. 0086-512-58900862; 400-0707-518; 0086-512-56727736
0086-512-56765862 sales@alabiochem.com China 944 59

View Lastest Price from Darunavir manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 Darunavir
206361-99-1
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-12-18 Darunavir
206361-99-1
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-12-18 Darunavir
206361-99-1
US $7.00 / kg 1kg 99% 100kg career henan chemical co

206361-99-1(Darunavir)Related Search:


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  • Heterocycles
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  • Darunaviroxy-1-phenylbutan-2-yl]carbamate
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